Research progress on the tsRNA biogenesis, function, and application in lung cancer
Non-coding RNA ResearchIn recent years, there has been a mounting occurrence of lung cancer, which stands as one of the most prevalent malignancies globally. This rise in incidence poses a significant hazard to human health, making lung cancer a matter of grave concern. It has
Shiwo Wu
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tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators
BiomoleculesAs the most ancient RNA, transfer RNAs (tRNAs) play a more complex role than their constitutive function as amino acid transporters in the protein synthesis process.
Yunfang Zhang +2 more
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The 3'tsRNAs are aminoacylated: Implications for their biogenesis. [PDF]
PLoS Genetics, 2021 Emerging evidence indicates that tRNA-derived small RNAs (tsRNAs) are involved in fine-tuning gene expression and become dysregulated in various cancers.
Ziwei Liu +4 more
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Scientific ReportsAccumulating evidence has shown that tRNA-derived small RNAs (tsRNAs) play crucial roles in malignant tumor development. However, whether serum tsRNAs can act as potential biological markers for hepatocellular carcinoma (HCC) are still largely unknown ...
Wei Zong, Yang Junling, Zong Wei
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Exosomal tsRNA-Gly-5-0007 may be used as a diagnostic marker for colorectal cancer [PDF]
Scientific ReportsColorectal cancer is one of the common malignant tumors nowadays, with the highest mortality rate among cancers, and most patients have metastasis when diagnosed.
Zhe Zhang +9 more
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Peripheral blood tRNA-derived fragments as novel noninvasive biomarkers for diagnosis and prognostic stratification in multiple myeloma [PDF]
Frontiers in ImmunologyBackgroundTransfer RNA-derived small RNAs (tsRNAs) have recently emerged as critical regulators in cancer biology; yet their expression profiles and clinical relevance in multiple myeloma (MM) remain poorly defined.MethodsHigh-throughput sequencing was ...
Biyun Yi +7 more
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Advances in the study of tsRNA as diagnostic and prognostic biomarkers in cancer [PDF]
Zhenduanxue lilun yu shijian, 2023 Transfer RNA (tRNA) promotes the protein translation process by binding with corresponding amino acids and transporting them to the ribosome, emphasizing the vital role of tRNA in protein translation.
WANG Shukui, GU Xinliang
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Targeting glycolytic reprogramming by tsRNA-0032 for treating pathological lymphangiogenesis
Cell Death and DiseaseLymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in several diseases such as cancers, inflammatory, and autoimmune diseases.
Fan Ye +7 more
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Machine learning-enhanced discovery of tsRNA-mRNA regulatory networks: identifying novel diagnostic biomarkers and therapeutic targets in breast cancer [PDF]
Frontiers in PharmacologyBackgroundTransfer RNA-derived small RNAs (tsRNAs) represent an emerging class of regulatory molecules with potential as cancer biomarkers. However, their diagnostic utility and regulatory mechanisms in breast cancer remain poorly characterized.
Zhongling Ma +6 more
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Emerging roles of tsRNAs in programmed cell death and disease therapeutics: challenges, opportunities, and future directions [PDF]
Non-coding RNA ResearchProgrammed cell death (PCD), which includes various forms such as apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis, plays a pivotal role in disease pathogenesis and progression.
Zhe Li +4 more
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