Results 31 to 40 of about 1,394 (153)

Development of a single vector system that enhances trans-splicing of SMN2 transcripts. [PDF]

PLoS ONE, 2008
RNA modalities are developing as a powerful means to re-direct pathogenic pre-mRNA splicing events. Improving the efficiency of these molecules in vivo is critical as they move towards clinical applications.
Tristan H Coady, Travis D Baughan, Monir Shababi, Marco A Passini, Christian L Lorson   +4 more
doaj   +1 more source

Development of a tRNA-derived small RNA diagnostic and prognostic signature in liver cancer

Genes and Diseases, 2022
Liver cancer presents divergent clinical behaviors. There remain opportunities for molecular markers to improve liver cancer diagnosis and prognosis, especially since tRNA-derived small RNAs (tsRNA) have rarely been studied.
Yi Zuo, Shaoqiu Chen, Lingling Yan, Ling Hu, Scott Bowler, Emory Zitello, Gang Huang, Youping Deng   +7 more
doaj   +1 more source

Identification of tRNA-derived RNAs in adipose tissue from overweight type 2 diabetes mellitus patients and their potential biological functions

Frontiers in Endocrinology, 2023
BackgroundType 2 diabetes mellitus (T2DM)causes a huge public health burden worldwide, especially for those who are overweight or obese, the pain is often greater.
Jie Zhang, Yingfei Xi, Qiuping Fei, Jun Xu, Jinxing Hu   +4 more
doaj   +1 more source

M1 macrophage-derived extracellular vesicle containing tsRNA-5006c promotes osteogenic differentiation of aortic valve interstitial cells through regulating mitophagy [PDF]

PeerJ, 2022
Background Osteogenic differentiation of aortic valve interstitial cells (AVICs) plays a key role in the calcific aortic valve disease progression. Extracellular vesicles (EVs)-derived from M1-polarized macrophages (M1-EVs) orchestrated intercellular ...
Hao Xia, Mingjian Gao, Jun Chen, Guanshen Huang, Xiuting Xiang, Yuyan Wang, Zhaohui Huang, Yongchun Li, Shuang Su, Zewei Zhao, Qingchun Zeng, Yunjun Ruan   +11 more
doaj   +2 more sources

Classification, function, and advances in tsRNA in non-neoplastic diseases

Cell Death & Disease, 2023
AbstracttRNA-derived small RNAs (tsRNAs) are non-coding small RNAs produced by specific endonucleases following the processing and splicing of precursor or mature tRNAs upon starvation, oxidative stress, hypoxia, and other adverse conditions. tRNAs are classified into two major categories, tRNA fragments (tRFs) and tRNA-derived stress-induced small ...
Liou Zhang, Jie Liu, Yang Hou
openaire   +3 more sources

Diagnostic and prognostic values of tsRNAs in lung cancer: A meta-analysis

BMC Cancer, 2023
Abstract Background Lung cancer (LC) is the leading cause of cancer death in humans. tRNA-derived small RNA (tsRNA) is a novel biomarker that plays a crucial role in the genesis and development of LC. In this study, we aimed to investigate the value of differentially expressed tsRNA in LC through meta-analysis.
Cheng Tang, Su-Xia Sun, Chao Gu, Chao-Juan Li, Jin Xu, Ke-Lei Su, Dan-Dan Zhou, Kuai Yu, Qing-Ling Xiao, Xiao-Li Chen   +9 more
openaire   +3 more sources

A tRNA-Derived Small RNA Regulates Ribosomal Protein S28 Protein Levels after Translation Initiation in Humans and Mice

Cell Reports, 2019
Summary: tRNA-derived small RNAs (tsRNAs) have been implicated in many cellular processes, yet the detailed mechanisms are not well defined. We previously found that the 3′ end of Leu-CAG tRNA-derived small RNA (LeuCAG3′tsRNA) regulates ribosome ...
Hak Kyun Kim, Jianpeng Xu, Kirk Chu, Hyesuk Park, Hagoon Jang, Pan Li, Paul N. Valdmanis, Qiangfeng Cliff Zhang, Mark A. Kay   +8 more
doaj   +1 more source

Differential Expression Analysis of tRNA-Derived Small RNAs from Subcutaneous Adipose Tissue of Obese and Lean Pigs

Animals, 2022
Epigenetic factors, including non-coding RNA regulation, play a vital role in the development of obesity and have been well researched. Transfer RNA-derived small RNA (tsRNA) is a class of non-coding RNA proven to be involved in various aspects of ...
Hao Gu, Mailin Gan, Linghui Wang, Yiting Yang, Jinyong Wang, Lei Chen, Shunhua Zhang, Ye Zhao, Lili Niu, Dongmei Jiang, Yiwu Chen, Anan Jiang, Linyuan Shen, Li Zhu   +13 more
doaj   +1 more source

Transfer RNA-derived small RNAs (tsRNAs) in gastric cancer

Frontiers in Oncology, 2023
Transfer RNA-derived small RNAs (tsRNAs) are newly discovered noncoding RNAs (ncRNAs). According to the specific cleavage of nucleases at different sites of tRNAs, the produced tsRNAs are divided into tRNA-derived stress-inducible RNAs (tiRNAs) and tRNA-derived fragments (tRFs).
Lu Gan, Haojun Song, Haojun Song, Xiaoyun Ding   +3 more
openaire   +3 more sources

m⁵C-Modified tRF3b-Cys^GCA-23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4. [PDF]

Adv Sci (Weinh)
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Ying X, Huang Y, Huang J, Cai Q, Zhang D, Chen C, Nie Y, Yang B, Li C, Hu W, Xiong C, Zhang C, Ji D, Liang Y, Yang M, Wu W, Ji W.   +16 more
europepmc   +2 more sources