Role of tRNA-derived small RNAs(tsRNAs) in the diagnosis and treatment of malignant tumours [PDF]
Cell Communication and Signaling, 2023 Malignant tumours area leading cause of death globally, accounting for approximately 13% of all deaths. A detailed understanding of the mechanism(s) of the occurrence and development of malignant tumours and identification of relevant therapeutic targets
Mingwen Mao +3 more
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The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis [PDF]
Non-coding RNA ResearchtRNA-derived small RNAs (tsRNAs), encompassing tRNA fragments (tRFs) and tRNA-derived stress-induced RNAs (tiRNAs), represent a category of non-coding small RNAs (sncRNAs) that are increasingly recognized for their diverse biological functions.
Yan Pan +5 more
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tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer [PDF]
Frontiers in GeneticsThe main function of transfer RNAs (tRNAs) is to carry amino acids into the ribosome and synthesize proteins under the guidance of messenger RNAs (mRNAs).
Li Gong +5 more
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tRNA-derived small RNAs (tsRNAs) in cardiovascular diseases: biogenesis, functions, and therapeutic targets [PDF]
Frontiers in Cardiovascular MedicinetRNA-derived small RNAs (tsRNAs) are a class of non-coding RNAs that are generated by cleavage of precursors or mature tRNAs under stress conditions such as hypoxia, oxidative stress and nutrient deficiency.
Chunfeng Xie +6 more
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The Liver Fluke Opisthorchis felineus Exosomal tRNA-Derived Small RNAs as Potential Mediators of Host Manipulation [PDF]
BiomoleculesThe role of extracellular vesicle non-coding RNAs in host–parasite interactions remains poorly understood, particularly for human liver flukes. Although tRNA-derived small RNAs (tsRNAs) are emerging as new regulatory molecules in parasite exosomes, they ...
Ekaterina Lishai, Maria Pakharukova
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Emerging roles and therapeutic potential of tRNA-Derived small RNAs in reproductive system diseases: a review [PDF]
Frontiers in Cell and Developmental BiologytRNA-derived small RNAs (tsRNAs) are a class of non-coding RNAs(ncRNAs) generated from precursor or mature tRNAs under stress conditions, such as starvation, hypoxia, or oxidative stress.
Qian Zhou +16 more
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tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy
Frontiers in Pharmacology, 2020 Transfer RNAs (tRNAs) are abundantly expressed, small non-coding RNAs that have long been recognized as essential components of the protein translation machinery.
Jun Cao, Douglas B. Cowan, Da-Zhi Wang
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Frontiers in Molecular Biosciences, 2021 Introduction: tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs, are divided into two categories: tRNA-related fragments (tRFs) and tRNA halves (tiRNAs).
Zhaoyi Lu +7 more
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Deciphering the tRNA-derived small RNAs: origin, development, and future
Cell Death and Disease, 2021 Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu +5 more
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Microarray Analysis Reveals Changes in tRNA-Derived Small RNAs (tsRNAs) Expression in Mice with Septic Cardiomyopathy [PDF]
Genes, 2022 Ludong Yuan +2 more
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