Results 31 to 40 of about 1,246 (105)

Emerging roles of tRNA-derived small RNAs in injuries [PDF]

PeerJ
tRNA-derived small RNAs (tsRNAs) are a novel class of small noncoding RNAs, precisely cleaved from tRNA, functioning as regulatory molecules. The topic of tsRNAs in injuries has not been extensively discussed, and studies on tsRNAs are entering a new era.
Mengjun Wang, Junfeng Guo, Wei Chen, Hong Wang, Xiaotong Hou   +4 more
doaj   +2 more sources

Emerging role of a novel small non-coding regulatory RNA: tRNA-derived small RNA [PDF]

ExRNA, 2019
The discovery of small non-coding RNAs, such as miRNA and piRNA, has dramatically changed our understanding of the role RNA plays in organisms. Recent studies show that a novel small non-coding RNA generated from cleavage of tRNA or pre-tRNA, called tRNA-
Fangfang Jin, Zhigang Guo
doaj   +1 more source

The epitranscriptome of small non-coding RNAs

Non-coding RNA Research, 2021
Small non-coding RNAs are short RNA molecules and involved in many biological processes, including cell proliferation and differentiation, immune response, cell death, epigenetic regulation, metabolic control.
Xiaoyu Li, Jinying Peng, Chengqi Yi
doaj   +1 more source

Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers

Genes and Diseases
With the development of sequencing technology, transfer RNA (tRNA)-derived small RNAs (tsRNAs) have received extensive attention as a new type of small noncoding RNAs.
Yu Zhang, Xinliang Gu, Yang Li, Yuejiao Huang, Shaoqing Ju   +4 more
doaj   +1 more source

Emerging roles of tRNA-derived small RNAs in cancer biology

Experimental and Molecular Medicine, 2023
Transfer RNAs (tRNAs) play an essential role in mRNA translation by delivering amino acids to growing polypeptide chains. Recent data demonstrate that tRNAs can be cleaved by ribonucleases, and the resultant cleavage products, tRNA-derived small RNAs ...
Saebyeol Lee, Jungeun Kim, Paul N. Valdmanis, Hak Kyun Kim   +3 more
doaj   +1 more source

The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review

Pharmacological Research
Transfer RNA-derived small RNAs (tsRNAs) are a class of small non-coding RNA (sncRNA) molecules derived from tRNA, including tRNA derived fragments (tRFs) and tRNA halfs (tiRNAs).
Kai Wang, Cui-Yun Liu, Bo Fang, Bo Li, Ying-Hui Li, Qian-Qian Xia, Yan Zhao, Xue-Li Cheng, Su-Min Yang, Mei-Hua Zhang, Kun Wang   +10 more
doaj   +1 more source

Dynamic changes in the transcriptome of tRNA-derived small RNAs related with fat metabolism

Scientific Data, 2023
The prevalence of obesity and overweight is steadily rising, posing a significant global challenge for humanity. The fundamental cause of obesity and overweight lies in the abnormal accumulation of adipose tissue.
Tianci Liao, Mailin Gan, Yuhang Lei, Yan Wang, Lei Chen, Linyuan Shen, Li Zhu   +6 more
doaj   +1 more source

Unravelling tRNA fragments in DENV pathogenesis: Insights from RNA sequencing

Scientific Reports
Small non-coding RNAs (sncRNAs) derived from tRNAs are known as tRNA-derived small RNAs (tsRNAs). These tsRNAs are further categorized into tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs), which play significant roles in the various molecular ...
Deeksha Madhry, Kiran Kumari, Varsha Meena, Riya Roy, Bhupendra Verma   +4 more
doaj   +1 more source

Unveiling the hidden world of transfer RNA-derived small RNAs in inflammation

Journal of Inflammation
Transfer RNA-derived small RNAs (tsRNAs) are a newly discovered class of small noncoding RNAs (sncRNAs) that include tRNA-derived stress-induced RNAs (tiRNAs) and tRNA-derived fragments (tRFs).
Peiru Qiu, Qi Jiang, Haojun Song
doaj   +1 more source

tRNA-derived small RNAs: their role in the mechanisms, biomarkers, and therapeutic strategies of colorectal cancer

Journal of Translational Medicine
Colorectal cancer (CRC) is the third most prevalent malignancy and the second leading cause of cancer-related mortality worldwide, with an increasing shift towards younger age of onset.
Bo Zhang, Yanru Pan, Zhe Li, Kefeng Hu
doaj   +1 more source