Circulating tRNA-derived small RNAs (tsRNAs) signature for the diagnosis and prognosis of breast cancer [PDF]
Npj Breast Cancer, 2021 AbstractLiquid biopsy is noninvasive and convenient to detect cancer-derived materials in blood or other body fluids. The aim of this study was to identify tRNA-derived small RNAs (tsRNAs) in plasma that could distinguish patients with breast cancer (BC) from healthy controls.
Xiaoan Liu, Shui Wang, Tiansong Xia
exaly +6 more sources
The Role of tRNA-Derived Small RNAs (tsRNAs) in Regulating Cell Death of Cardiovascular Diseases [PDF]
BiologyTransfer RNA is a class of non-coding RNA that plays a role in amino acid translocation during protein synthesis. After specific modification, the cleaved fragment is called tRNA-derived small RNA. The advancement of bioinformatics technology has led to an increase in the visibility of small RNA derived from tRNA, and their functions in biological ...
Xinzhe Chen, Sumin Yang, Yang Sumin
exaly +5 more sources
Transfer RNA-derived small RNAs in cardiovascular diseases: Progress and perspectives [PDF]
Non-coding RNA ResearchtRNA-derived small RNAs (tsRNAs) are a class of noncoding RNAs (ncRNAs) generated via the site-specific enzymatic cleavage of mature or precursor tRNAs.
Xinru Wen +4 more
doaj +2 more sources
tRNA-derived small RNAs in digestive tract diseases: Progress and perspectives
Genes and DiseasestRNA-derived small RNAs (tsRNAs) are non-coding small RNAs that are produced through the precise cleavage of tRNA molecules under specific conditions. tsRNA has multiple functions, including inhibiting translation, acting in association with classical ...
Mingrui Liu +4 more
doaj +3 more sources
Biological roles and potential clinical value of tRNA-derived small RNAs in gastrointestinal malignancies [PDF]
Annals of MedicinetRNA-derived small RNAs (tsRNAs) are small RNA fragments generated from tRNA molecules or their precursors through cleavage by enzymes such as Dicer. As noncoding small RNAs, tsRNAs have important biological functions, including regulating mRNA stability
Yongfu Shao +5 more
doaj +2 more sources
Deciphering the contribution of 5’-tiRNA- Lys-CTT as an emerging early diagnostic biomarker for hepatocellular carcinoma [PDF]
Discover OncologyHepatocellular carcinoma (HCC) remains a leading cause of cancer mortality worldwide, with early detection critical for improving survival rates. Late-stage diagnosis contributes to dismal prognosis.
Abinash Nayak
doaj +2 more sources
Decoding tRNA dynamics in neuroimmune disorders: mechanistic insights, diagnostic innovations, and therapeutic opportunities [PDF]
Frontiers in ImmunologyTransfer RNA (tRNA) and its derivatives, once regarded solely as translational adaptors, are now recognized as pivotal regulators of neuroimmune homeostasis.
Enlin Liang +5 more
doaj +2 more sources
The Emerging Role of tRNA-Derived Small RNAs (tsRNAs) in Radiation-Induced Cardiovascular Pathology [PDF]
Endocr Metab Immune Disord Drug TargetsIntroduction: Ionizing radiation exposure during thoracic radiotherapy is a risk factor for long-term cardiovascular morbidity, including radiation-induced heart disease (RIHD). Emerging evidence implicates transfer RNA-derived small RNAs (tsRNAs) as stress-responsive regulatory molecules, yet their roles in ...
Chen Y, Zhu Y, Qian L, Hu Q.
europepmc +2 more sources
Classification, function, and advances in tsRNA in non-neoplastic diseases
Cell Death and Disease, 2023 tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs produced by specific endonucleases following the processing and splicing of precursor or mature tRNAs upon starvation, oxidative stress, hypoxia, and other adverse conditions.
Liou Zhang, Jie Liu, Yang Hou
doaj +1 more source
tRNA-derived small RNAs: Mechanisms and potential roles in cancers
Genes and Diseases, 2022 Transfer RNAs (tRNAs) are essential for protein synthesis. Mature or pre-tRNAs may be cleaved to produce tRNA-derived small RNAs (tsRNAs). tsRNAs, divided into tRNA-derived stress-induced RNA (tiRNAs) and tRNA-derived fragments (tRFs), play versatile ...
Yao Wang +5 more
doaj +1 more source