Results 41 to 50 of about 1,246 (105)

tRNA-derived small RNAs: novel regulators of cancer hallmarks and targets of clinical application

Cell Death Discovery, 2021
tRNAs are a group of conventional noncoding RNAs (ncRNAs) with critical roles in the biological synthesis of proteins. Recently, tRNA-derived small RNAs (tsRNAs) were found to have important biological functions in the development of human diseases ...
Xizhe Li, Xianyu Liu, Deze Zhao, Weifang Cui, Yingfang Wu, Chunfang Zhang, Chaojun Duan   +6 more
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Regulation of plant gene expression by tsRNAs in response to abiotic stress [PDF]

PeerJ
Objective Transfer RNA-derived small RNAs (tsRNAs) are emerging regulators of gene expression in response to abiotic stress. This review aims to summarize recent advances in the classification, biogenesis, and biological functions of tsRNAs, with a focus
Chunmei Li, Jing Zhu, Han Jin, Haotian Feng, Haimin Zhuang, Zijun Du, Guolin Zhu, Haiyang He, Fuyang Ye, Zhaohui Mo, Qingtao Hu, Zhenbang Chen, Kai Liu, Xiaorong Wan   +13 more
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The 3'tsRNAs are aminoacylated: Implications for their biogenesis.

PLoS Genetics, 2021
Emerging evidence indicates that tRNA-derived small RNAs (tsRNAs) are involved in fine-tuning gene expression and become dysregulated in various cancers.
Ziwei Liu, Hak Kyun Kim, Jianpeng Xu, Yuqing Jing, Mark A Kay   +4 more
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Differential Expression Profiles and Function Predictions for tRFs & tiRNAs in Skin Injury Induced by Ultraviolet Irradiation

Frontiers in Cell and Developmental Biology, 2021
Ultraviolet (UV) radiation is a major environmental factor contributing skin damage. As UV exposure is inevitable, it is necessary to pay attention to the underlying molecular mechanisms of UV-induced skin damage to develop effective therapies.
Yuan Fang, Yang Liu, Yu Yan, Yiyu Shen, Zenan Li, Xu Li, Yufang Zhang, Zhigang Xue, Cong Peng, Cong Peng, Cong Peng, Cong Peng, Xiang Chen, Xiang Chen, Xiang Chen, Xiang Chen, Ke Cao, Jianda Zhou   +17 more
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Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury

Neural Regeneration Research, 2022
Transfer RNA (tRNA)-derived small RNAs (tsRNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes.
Xiao-Jian Xu, Meng-Shi Yang, Bin Zhang, Qian-Qian Ge, Fei Niu, Jin-Qian Dong, Yuan Zhuang, Bai-Yun Liu   +7 more
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tRNA-derived small RNA, tsRNA-5017b, as a novel biomarker for predicting severity in severe fever with thrombocytopenia syndrome

Microbiology Spectrum
ABSTRACT tRNA-derived small RNAs (tsRNAs) represent a novel class of highly conserved non-coding RNAs that play crucial roles in various cellular processes, including cell proliferation and the initiation of viral reverse transcription.
Wanying Zhang, Jiawei Feng, Shixing Chen, Na Cao, Shuo Ma, Jiale Li, Linyan Gong, Haiyan Gao, Tianyang Liu, Xiaofeng Cheng, Hongpan Xu, Yuxin Chen   +11 more
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Human small non-coding tRNA-derived fragments as key hallmarks of host-virus interaction in viral infections

Cell & Bioscience
Viral infections cause deep changes in the host transcriptome, triggering a complex antiviral immune response that involves multiple proteins and molecular and cellular signaling pathways.
Mahsa Aghajani Mir, Parisa Sharifi, Fatemeh Gila, Hamid Askari, Marjan Nourigorji, Farahnaz Zare, Sara Karimi, Zahra Saadatian, Abdolreza Daraei   +8 more
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The function of tRNA-derived small RNAs in cardiovascular diseases

Molecular Therapy: Nucleic Acids
tRNA-derived small RNAs (tsRNAs) constitute a subgroup of small noncoding RNAs (ncRNAs) originating from tRNA molecules. Their rich content, evolutionary conservatism, high stability, and widespread existence makes them significant in disease research ...
Yan Zhao, Kai Wang, Chun Zhao, Ning Liu, Zhihong Wang, Wenting Yang, Zewei Cheng, Luyu Zhou, Kun Wang   +8 more
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Pathological significance of tRNA-derived small RNAs in neurological disorders

Neural Regeneration Research, 2020
Non-coding RNAs (ncRNAs) are a type of RNA that is not translated into proteins. Transfer RNAs (tRNAs), a type of ncRNA, are the second most abundant type of RNA in cells.
Chuan Qin, Pei-Pei Xu, Xin Zhang, Chao Zhang, Chang-Bin Liu, De-Gang Yang, Feng Gao, Ming-Liang Yang, Liang-Jie Du, Jian-Jun Li   +9 more
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Peripheral blood non-canonical small non-coding RNAs as novel biomarkers in lung cancer

Molecular Cancer, 2020
One unmet challenge in lung cancer diagnosis is to accurately differentiate lung cancer from other lung diseases with similar clinical symptoms and radiological features, such as pulmonary tuberculosis (TB).
Wanjun Gu, Junchao Shi, Hui Liu, Xudong Zhang, Jin J. Zhou, Musheng Li, Dandan Zhou, Rui Li, Jingzhu Lv, Guoxia Wen, Shanshan Zhu, Ting Qi, Wei Li, Xiaojing Wang, Zhaohua Wang, Hua Zhu, Changcheng Zhou, Kenneth S. Knox, Ting Wang, Qi Chen, Zhongqing Qian, Tong Zhou   +21 more
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