tRNA derived small RNAs—Small players with big roles [PDF]
Frontiers in Genetics, 2022 In the past 2 decades, small non-coding RNAs derived from tRNA (tsRNAs or tRNA derived fragments; tRFs) have emerged as new powerful players in the field of small RNA mediated regulation of gene expression, translation, and epigenetic control.
Suja George +6 more
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Emerging roles and therapeutic potential of tRNA-Derived small RNAs in reproductive system diseases: a review [PDF]
Frontiers in Cell and Developmental BiologytRNA-derived small RNAs (tsRNAs) are a class of non-coding RNAs(ncRNAs) generated from precursor or mature tRNAs under stress conditions, such as starvation, hypoxia, or oxidative stress.
Qian Zhou +16 more
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Function and Therapeutic Implications of tRNA Derived Small RNAs [PDF]
Frontiers in Molecular Biosciences, 2022 tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from ...
Briana Wilson, Anindya Dutta
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Role of tRNA-derived small RNAs(tsRNAs) in the diagnosis and treatment of malignant tumours [PDF]
Cell Communication and Signaling, 2023 Malignant tumours area leading cause of death globally, accounting for approximately 13% of all deaths. A detailed understanding of the mechanism(s) of the occurrence and development of malignant tumours and identification of relevant therapeutic targets
Mingwen Mao +3 more
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Emerging roles of tRNA-derived small RNAs in cancer biology [PDF]
Experimental and Molecular Medicine, 2023 Transfer RNAs (tRNAs) play an essential role in mRNA translation by delivering amino acids to growing polypeptide chains. Recent data demonstrate that tRNAs can be cleaved by ribonucleases, and the resultant cleavage products, tRNA-derived small RNAs ...
Saebyeol Lee +3 more
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Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans [PDF]
BMC Biology, 2023 Background The individual lifestyle and environment of an organism can influence its phenotype and potentially the phenotype of its offspring. The different genetic and non-genetic components of the inheritance system and their mutual interactions are ...
Manon Fallet +2 more
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Emerging roles of tRNA-derived small RNAs in injuries [PDF]
PeerJtRNA-derived small RNAs (tsRNAs) are a novel class of small noncoding RNAs, precisely cleaved from tRNA, functioning as regulatory molecules. The topic of tsRNAs in injuries has not been extensively discussed, and studies on tsRNAs are entering a new era.
Mengjun Wang +4 more
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tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer [PDF]
Frontiers in GeneticsThe main function of transfer RNAs (tRNAs) is to carry amino acids into the ribosome and synthesize proteins under the guidance of messenger RNAs (mRNAs).
Li Gong +5 more
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Frontiers in Molecular Biosciences, 2021 Introduction: tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs, are divided into two categories: tRNA-related fragments (tRFs) and tRNA halves (tiRNAs).
Zhaoyi Lu +7 more
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The Liver Fluke Opisthorchis felineus Exosomal tRNA-Derived Small RNAs as Potential Mediators of Host Manipulation [PDF]
BiomoleculesThe role of extracellular vesicle non-coding RNAs in host–parasite interactions remains poorly understood, particularly for human liver flukes. Although tRNA-derived small RNAs (tsRNAs) are emerging as new regulatory molecules in parasite exosomes, they ...
Ekaterina Lishai, Maria Pakharukova
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