Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves [PDF]
MBio, 2023 tRNA-derived fragments have been reported in many different organisms and have diverse cellular roles, such as regulating gene expression, inhibiting protein translation, silencing transposable elements, and modulating cell proliferation.
Upinder Singh +2 more
exaly +4 more sources
tRFs and tRNA Halves: Novel Cellular Defenders in Multiple Biological Processes [PDF]
Current Issues in Molecular Biology, 2022 tRNA fragments derived from angiogenin or Dicer cleavage are referred to as tRNA-derived fragments (tRFs) and tRNA halves. tRFs and tRNA halves have been identified in both eukaryotes and prokaryotes and are precisely cleaved at specific sites on either ...
Jiani Hou +3 more
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The Typical tRNA Co-Expresses Multiple 5′ tRNA Halves Whose Sequences and Abundances Depend on Isodecoder and Isoacceptor and Change with Tissue Type, Cell Type, and Disease [PDF]
Non-coding RNA, 2023 Transfer RNA-derived fragments (tRFs) are noncoding RNAs that arise from either mature transfer RNAs (tRNAs) or their precursors. One important category of tRFs comprises the tRNA halves, which are generated through cleavage at the anticodon.
Phillipe Loher +2 more
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Profiling of tRNA Halves and YRNA Fragments in Serum and Tissue From Oral Squamous Cell Carcinoma Patients Identify Key Role of 5′ tRNA-Val-CAC-2-1 Half [PDF]
Frontiers in Oncology, 2019 Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer and, as indicated by The Oral Cancer Foundation, kills at an alarming rate of roughly one person per hour.
Berta Victoria Martinez +2 more
exaly +4 more sources
Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance [PDF]
Biomarker Research, 2020 The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers.
Yue Zhang, Huizhu Qian, Jing He, Wen Gao
doaj +2 more sources
Antitumor Activities of tRNA-Derived Fragments and tRNA Halves from Non-pathogenic Escherichia coli Strains on Colorectal Cancer and Their Structure-Activity Relationship [PDF]
mSystems, 2022 tRNAs purified from non-pathogenic Escherichia coli strains (NPECSs) possess cytotoxic properties on colorectal cancer cells. In the present study, the bioactivity of tRNA halves and tRNA fragments (tRFs) derived from NPECSs are investigated for their ...
Kai-Yue Cao +5 more
doaj +2 more sources
Sequence Evidence in the Archaeal Genomes that tRNAs Emerged Through the Combination of Ancestral Genes as 5′ and 3′ tRNA Halves [PDF]
PLoS ONE, 2008 The discovery of separate 5' and 3' halves of transfer RNA (tRNA) molecules-so-called split tRNA-in the archaeal parasite Nanoarchaeum equitans made us wonder whether ancestral tRNA was encoded on 1 or 2 genes.
Akio Kanai +2 more
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Analysis of tRNA halves (tsRNAs) in serum from cattle challenged with bovine viral diarrhea virus [PDF]
Genetics and Molecular Biology, 2019 Acute infections of bovine viral diarrhea virus (BVDV) lead to a range of clinical presentations. Laboratory tests for detection depend on collection of samples during a short viremia. Acutely infected animals remain largely undiagnosed.
Tasia M. Taxis +3 more
doaj +2 more sources
A hormone-dependent tRNA half promotes cell cycle progression via destabilization of p21 mRNA. [PDF]
PLoS BiologytRNA halves are among the most abundant short non-coding RNAs in the cellular transcriptome. Here we report that in androgen receptor-positive LNCaP prostate cancer cells, the hormone-dependent 5'-tRNALysCUU half promoted cell proliferation by ...
Takuya Kawamura +2 more
doaj +2 more sources
Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2023 Bruno Costa +2 more
exaly +2 more sources