Large-Scale Computational Discovery of Binding Motifs in tRNA Fragments [PDF]
Frontiers in Molecular Biosciences, 2021 Accumulating evidence has suggested that tRNA-derived fragments (tRFs) could be loaded to Argonaute proteins and function as regulatory small RNAs. However, their mode of action remains largely unknown, and investigations of their binding mechanisms have
Lingyu Guan +2 more
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Gammaherpesvirus infection triggers the formation of tRNA fragments from premature tRNAs [PDF]
mBioTransfer RNAs (tRNAs) are fundamental for both cellular and viral gene expression during viral infection. In addition, mounting evidence supports the biological function for tRNA cleavage products, including the control of gene expression during ...
Aidan C. Manning +10 more
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Beyond the Ribosome: Extra-translational Functions of tRNA Fragments [PDF]
Biomarker Insights, 2016 High-throughput sequencing studies of small RNAs reveal a complex milieu of noncoding RNAs in biological samples. Early data analysis was often limited to microRNAs due to their regulatory nature and potential as biomarkers; however, many more classes of
Kevin W. Diebel +3 more
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Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR [PDF]
eLifeAmong the major classes of RNAs in the cell, tRNAs remain the most difficult to characterize via deep sequencing approaches, as tRNA structure and nucleotide modifications can each interfere with cDNA synthesis by commonly used reverse transcriptases ...
Hans Tobias Gustafsson +8 more
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tRNA Fragments Populations Analysis in Mutants Affecting tRNAs Processing and tRNA Methylation [PDF]
Frontiers in Genetics, 2020 tRNA fragments (tRFs) are a class of small non-coding RNAs (sncRNAs) derived from tRNAs. tRFs are highly abundant in many cell types including stem cells and cancer cells, and are found in all domains of life.
Anahi Molla-Herman +5 more
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The widespread occurrence of tRNA‐derived fragments in Saccharomyces cerevisiae
FEBS Open Bio, 2016 Short RNAs derived from the cleavage of tRNA molecules are observed in most organisms. Their occurrence seems to be induced by stress conditions, but still little is known about their biogenesis and functions.
Kamilla Bąkowska‐Żywicka +5 more
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Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation [PDF]
Cell Reports, 2018 Summary: The discovery of microRNA (miRNA) sorting into extracellular vesicles (EVs) revealed a novel mode of intercellular communication and uncovered a link between cellular endomembrane compartments and small RNAs in EV-secreting cells.
Ni-Ting Chiou +2 more
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Mapping Current Studies of tRNA Fragments onto Disease Landscape [PDF]
BiomoleculesTransfer-RNA-derived fragments (tRFs) are a relatively recently discovered class of non-coding RNAs derived from both precursor and mature transfer RNAs (tRNAs).
Sathyanarayanan Vaidhyanathan +16 more
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Life, 2015 This review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs).
Simon P. Keam, Gyorgy Hutvagner
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Menstrual cycle-dependent expression of tRNA-derived fragments in healthy human endometrium and uterine fluid-derived extracellular vesicles [PDF]
BMC GenomicsThe human endometrium undergoes dynamic cyclical remodeling across the menstrual cycle to establish receptivity for embryo implantation. While microRNAs are established regulators of endometrial function and embryo–maternal communication, the ...
Apostol Apostolov +8 more
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