Results 31 to 40 of about 68,298 (102)
Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
Biomarker Research, 2020 The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers.
Yue Zhang, Huizhu Qian, Jing He, Wen Gao
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tRNA-Derived Small RNAs: A Novel Regulatory Small Noncoding RNA in Renal Diseases
Kidney Diseases, 2023 Background: tRNA-derived small RNAs (tsRNAs) are an emerging class of small noncoding RNAs derived from tRNA cleavage. Summary: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including
Dan Li +6 more
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Cell Reports, 2013 Transfer RNA (tRNA) fragmentation in response to stress conditions has been described in many organisms. tRNA fragments have been found in association with small interfering RNA (siRNA) components, but the biological role of these interactions remains ...
Zeljko Durdevic +4 more
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Cell Death and Disease, 2023 Chondrosarcoma is ineffective for conventional radiotherapy and chemotherapy with a poor prognosis. Hedgehog (Hh) signal pathway plays a crucial role in tumor growth and progression, which is constitutive activated in chondrosarcoma.
Yifeng Sun +4 more
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Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases [PDF]
Genomics & Informatics, 2015 tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles
Yu Fu +3 more
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The Small Non-Coding RNA Profile of Human and Mouse Sperm
Non-Coding RNASmall non-coding RNAs constitute a dynamic epigenetic layer in mature spermatozoa that can exert transgenerational regulatory functions. Here, we review recent advances in the field of small RNAs in spermatozoa, how their profiles change in response to ...
Yoon Sing Yap +4 more
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tRFTars: predicting the targets of tRNA-derived fragments
Journal of Translational Medicine, 2021 Background tRNA-derived fragments (tRFs) are 14–40-nucleotide-long, small non-coding RNAs derived from specific tRNA cleavage events with key regulatory functions in many biological processes.
Qiong Xiao +8 more
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tRNA-derived fragments as novel potential biomarkers for relapsed/refractory multiple myeloma
BMC Bioinformatics, 2021 Background tRNA-derived fragments have been reported to be key regulatory factors in human tumors. However, their roles in the progression of multiple myeloma remain unknown.
Cong Xu +4 more
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Regulatory roles of tRNA-derived RNA fragments in human pathophysiology
Molecular Therapy: Nucleic Acids, 2021 Hundreds of tRNA genes and pseudogenes are encoded by the human genome. tRNAs are the second most abundant type of RNA in the cell. Advancement in deep-sequencing technologies have revealed the presence of abundant expression of functional tRNA-derived ...
Kush Kumar Pandey +7 more
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tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy
Frontiers in Pharmacology, 2020 Transfer RNAs (tRNAs) are abundantly expressed, small non-coding RNAs that have long been recognized as essential components of the protein translation machinery.
Jun Cao, Douglas B. Cowan, Da-Zhi Wang
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