Results 51 to 60 of about 68,298 (102)

Sex-specific declines in cholinergic-targeting tRNA fragments in the nucleus accumbens in Alzheimer's disease. [PDF]

Alzheimers Dement, 2023
Shulman D, Dubnov S, Zorbaz T, Madrer N, Paldor I, Bennett DA, Seshadri S, Mufson EJ, Greenberg DS, Loewenstein Y, Soreq H.   +10 more
europepmc   +1 more source

Differential prognostic roles and clinical implications of mitochondrial and genomic tRNA-derived fragments in colorectal liver metastases

Journal of Translational Medicine
Background Colorectal liver metastases (CRLM) are the leading cause of colorectal cancer (CRC)-related mortality. Transfer RNA-derived fragments (tRFs), a novel class of small non-coding RNAs (sncRNA), regulate gene expression, stress response, and ...
Rebecca Zirnbauer, Daphni Ammon, Annalena Renner, Noam Hartman, Polina Kalinina, Patrick Starlinger, Stefan Stremitzer, Christoph Schwarz, Klaus Kaczirek, Michael Bergmann, Dietmar Pils, Johannes Laengle   +11 more
doaj   +1 more source

tRNA-derived small RNAs (tsRNAs): establishing their dominance in the regulation of human cancer

Frontiers in Genetics
The main function of transfer RNAs (tRNAs) is to carry amino acids into the ribosome and synthesize proteins under the guidance of messenger RNAs (mRNAs).
Li Gong, Yajie Hu, Ling Pan, Ling Pan, Yufeng Cheng, Yufeng Cheng   +5 more
doaj   +1 more source

Posttranscriptional 3′-Terminal Modifications of Escherichia coli RNA Fragments Evolved for Diversity Boosting

Microorganisms
An emerging area of microbial biology focuses on oligonucleotides excised from functional RNAs and subsequently fulfilling an independent cellular role.
Nikita M. Kamoldinov, Valery V. Panyukov, Nikolay P. Kolzhetsov, Natalia Y. Markelova, Konstantin S. Shavkunov, Uliana S. Shvyreva, Olga V. Alikina, Olga A. Glazunova, Iuliia A. Praslova, Olga N. Ozoline   +9 more
doaj   +1 more source

NGS Data Repurposing Allows Detection of tRNA Fragments as Gastric Cancer Biomarkers in Patient-Derived Extracellular Vesicles. [PDF]

Int J Mol Sci, 2023
Maqueda JJ, Santos M, Ferreira M, Marinho S, Rocha S, Rocha M, Saraiva N, Bonito N, Carvalho J, Oliveira C.   +9 more
europepmc   +1 more source

Honeybee Iflaviruses Pack Specific tRNA Fragments from Host Cells in Their Virions. [PDF]

Chembiochem, 2022
Šimonová A, Romanská V, Benoni B, Škubník K, Šmerdová L, Procházková M, Spustová K, Moravčík O, Gahurova L, Pačes J, Plevka P, Cahová H.   +11 more
europepmc   +1 more source

Transfer RNA expression, modification, and derived small RNAs in cancer biology and clinical potential

Frontiers in Immunology
Transfer RNA (tRNA) is essential for protein synthesis and undergoes diverse chemical modifications that regulate its stability and function. Dysregulation of tRNA expression and modifications, along with the activity of tRNA-derived small RNAs (tsRNAs ...
Ming Luo, Ji’an Liu, Yang Su, Rao Fu, Xufeng Huang, Xufeng Huang, Qi Wang, Jing Li, Zhengrui Li, Li Liu   +9 more
doaj   +1 more source

Possible Roles of tRNA Fragments, as New Regulatory ncRNAs, in the Pathogenesis of Rheumatoid Arthritis. [PDF]

Int J Mol Sci, 2021
Yamasaki S, Nakashima M, Ida H.
europepmc   +1 more source

Transfer RNA Fragments in the Kidney in Hypertension. [PDF]

Hypertension, 2021
Pan X, Geng X, Liu Y, Yu M, Mishra MK, Xu X, Ding X, Liu P, Liang M.   +8 more
europepmc   +1 more source

Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome. [PDF]

Nat Cell Biol, 2022
Guzzi N, Muthukumar S, Cieśla M, Todisco G, Ngoc PCT, Madej M, Munita R, Fazio S, Ekström S, Mortera-Blanco T, Jansson M, Nannya Y, Cazzola M, Ogawa S, Malcovati L, Hellström-Lindberg E, Dimitriou M, Bellodi C.   +17 more
europepmc   +1 more source