Results 21 to 30 of about 68,298 (102)

Quantification of substoichiometric modification reveals global tsRNA hypomodification, preferences for angiogenin-mediated tRNA cleavage, and idiosyncratic epitranscriptomes of human neuronal cell-lines

open access: yesComputational and Structural Biotechnology Journal, 2023
Modification of tRNA is an integral part of the epitranscriptome with a particularly pronounced potential to generate diversity in RNA expression. Eukaryotic tRNA contains modifications in up to 20% of their nucleotides, but not all sites are always ...
Florian Pichot   +9 more
doaj   +1 more source

Multiple Layers of Stress-Induced Regulation in tRNA Biology

open access: yesLife, 2016
tRNAs are the fundamental components of the translation machinery as they deliver amino acids to the ribosomes during protein synthesis. Beyond their essential function in translation, tRNAs also function in regulating gene expression, modulating ...
Hsiao-Yun Huang, Anita K. Hopper
doaj   +1 more source

On distinguishing between canonical tRNA genes and tRNA gene fragments in prokaryotes

open access: yesRNA Biology, 2023
Automated genome annotation is essential for extracting biological information from sequence data. The identification and annotation of tRNA genes is frequently performed by the software package tRNAscan-SE, the output of which is listed for selected ...
Peter T.S. van der Gulik   +7 more
doaj   +1 more source

Disrupted tRNA Genes and tRNA Fragments: A Perspective on tRNA Gene Evolution

open access: yesLife, 2015
Transfer RNAs (tRNAs) are small non-coding RNAs with lengths of approximately 70–100 nt. They are directly involved in protein synthesis by carrying amino acids to the ribosome.
Akio Kanai
doaj   +1 more source

A 5′-tRNA halve, tiRNA-Gly promotes cell proliferation and migration via binding to RBM17 and inducing alternative splicing in papillary thyroid cancer

open access: yesJournal of Experimental & Clinical Cancer Research, 2021
Background tRNA-derived small noncoding RNAs (sncRNAs) are mainly categorized into tRNA halves (tiRNAs) and fragments (tRFs). Biological functions of tiRNAs in human solid tumor are attracting more and more attention, but researches concerning the ...
Litao Han   +13 more
doaj   +1 more source

Signature of circulating small non-coding RNAs during early fracture healing in mice

open access: yesBone Reports, 2022
Fracture healing is a complex process with multiple overlapping metabolic and differentiation phases. Small non-coding RNAs are involved in the regulation of fracture healing and their presence in circulation is under current interest due to their ...
Matthieu Bourgery   +9 more
doaj   +1 more source

Distinct subcellular localization of tRNA-derived fragments in the infective metacyclic forms of Trypanosoma cruzi

open access: yesMemorias do Instituto Oswaldo Cruz, 2012
Small non-coding RNAs derived from transfer RNAs have been identified as a broadly conserved prokaryotic and eukaryotic response to stress. Their presence coincides with changes in developmental state associated with gene expression regulation.
Larissa Reifur   +8 more
doaj   +1 more source

tRNA Biology in Trypanosomes

open access: yesCHIMIA, 2019
Besides their medical importance, the parasitic protozoan Trypanosoma brucei and its relatives are experimentally highly accessible model systems for many cell biological processes.
Shikha Shikha   +3 more
doaj   +1 more source

Transgenerational Response to Heat Stress in the Form of Differential Expression of Noncoding RNA Fragments in Brassica rapa Plants

open access: yesThe Plant Genome, 2019
Epigenetic regulations in the form of changes in differential expression of noncoding RNAs (ncRNAs) are an essential mechanism of stress response in plants. Previously we showed that heat treatment in L.
Boseon Byeon   +2 more
doaj   +1 more source

The production and secretion of tRNA-derived RNA fragments in the corn smut fungus Ustilago maydis

open access: yesFrontiers in Fungal Biology, 2022
The biogenesis of small non-coding RNAs is a molecular event that contributes to cellular functions. The basidiomycete fungus Ustilago maydis is a biotrophic pathogen parasitizing maize.
Rei Yoshimoto   +3 more
doaj   +1 more source

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