5’ tRNA halves may function as immune signaling molecules [PDF]
Frontiers in Immunology, 2015 Non-coding small RNAs including tRNA, rRNA, snoRNA, and Y RNA, have been recently shown to undergo processing into smaller RNA molecules (1, 2). These derivatives of known small RNAs are not merely degradation products but are specific cleavage products that function in patho-physiological conditions (3–5).
Joseph Mohsen Dhahbi +1 more
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Elevated tRNA halves in olfactory epithelial cells of patients with schizophrenia [PDF]
The Journal of Clinical InvestigationSchizophrenia patients' olfactory epithelial cells contain abundant immune-activating tRNA fragments, linking small RNA biology to inflammation and suggesting avenues for diagnostics.
Justin T. Gumas +4 more
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Using tRNA halves as novel biomarkers for the diagnosis of gastric cancer [PDF]
Cancer Biomarkers, 2019 BACKGROUND: tRNA halves (tiRNAs) are produced from mature tRNAs. They have important roles both with in normal cells and cancer cells. However, the diagnostic value of tiRNAs in cancers have not yet been elucidated. OBJECTIVE: To explore the diagnostic value of tiRNA-5034-GluTTC-2 in gastric cancer.
Tianwen Li, Bingxiu Xiao, Junming Guo
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Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3–mediated gene silencing [PDF]
Journal of Biological Chemistry, 2019 tRNA fragments (tRFs) and tRNA halves have been implicated in various cellular processes, including gene silencing, translation, stress granule assembly, cell differentiation, retrotransposon activity, symbiosis, apoptosis, and more. Overexpressed angiogenin (ANG) cleaves tRNA anticodons and produces tRNA halves similar to those produced in response to
Zhangli Su +2 more
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Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Although transfer RNAs (tRNAs) are best known as adapter molecules essential for translation, recent biochemical and computational evidence has led to a previously unexpected conceptual consensus that tRNAs are not always end products but can further serve as a source of small functional RNAs.
Yohei Kirino +2 more
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5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction [PDF]
BMC Genomics, 2013 Small RNAs complex with proteins to mediate a variety of functions in animals and plants. Some small RNAs, particularly miRNAs, circulate in mammalian blood and may carry out a signaling function by entering target cells and modulating gene expression. The subject of this study is a set of circulating 30-33 nt RNAs that are processed derivatives of the
Dario Boffelli +2 more
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Ribonuclease DIS3 delays aging and senescence by generating tRNA halves
Nature CommunicationsTransfer RNA (tRNA) halves (tRHs) are generated via the cleavage of tRNAs, but their roles in aging and longevity remain poorly understood. Here, we demonstrate a direct role of tRHs in aging in metazoans.
Seokjun G. Ha +19 more
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Staying together after the breakup: tRNA halves in extracellular fluids. [PDF]
Proc Natl Acad Sci U S A, 2023 Kaymak E, Rando OJ.
europepmc +3 more sources
tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans [PDF]
Nature CommunicationsThe environment encountered by an organism can modulate epigenetic information in gametes to transmit non-genetically inherited phenotypes to offspring. In mouse models, the diet of males regulates specific tRNA-derived RNAs (tDRs) in sperm.
Nicholas S. Galambos +9 more
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Role of tRNA-Derived Fragments in Protozoan Parasite Biology [PDF]
CellstRNA molecules are among the most fundamental and evolutionarily conserved RNA types, primarily facilitating the translation of genetic information from mRNA into proteins.
Manu Sharma, Upinder Singh
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