Results 31 to 40 of about 4,159 (191)
tRNA-derived fragments as novel potential biomarkers for relapsed/refractory multiple myeloma
BMC Bioinformatics, 2021 Background tRNA-derived fragments have been reported to be key regulatory factors in human tumors. However, their roles in the progression of multiple myeloma remain unknown.
Cong Xu +4 more
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Function and Therapeutic Implications of tRNA Derived Small RNAs
Frontiers in Molecular Biosciences, 2022 tRNA derived small RNAs are mainly composed of tRNA fragments (tRFs) and tRNA halves (tiRs). Several functions have been attributed to tRFs and tiRs since their initial characterizations, spanning all aspects of regulation of the Central Dogma: from ...
Briana Wilson, Anindya Dutta
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Infection-induced 5'-half molecules of tRNAHisGUG activate Toll-like receptor 7.
PLoS Biology, 2020 Toll-like receptors (TLRs) play a crucial role in the innate immune response. Although endosomal TLR7 recognizes single-stranded RNAs, their endogenous RNA ligands have not been fully explored.
Kamlesh Pawar +3 more
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Frontiers in Molecular Biosciences, 2021 Introduction: tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs, are divided into two categories: tRNA-related fragments (tRFs) and tRNA halves (tiRNAs).
Zhaoyi Lu +7 more
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Genome-Wide Analysis Reveals Origin of Transfer RNA Genes from tRNA Halves [PDF]
Molecular Biology and Evolution, 2013 Transfer RNAs (tRNAs) play an important role linking mitochondrial RNA and amino acids during protein biogenesis. Four types of tRNA genes have been identified in living organisms. However, the evolutionary origin of tRNAs remains largely unknown. In this article, we conduct a deep sequence analysis of diverse genomes that cover all three domains of ...
Zhixiang, Zuo +5 more
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RNA, 2023 Transfer RNA fragments are proposed to regulate numerous processes in eukaryotes, including translation inhibition, epigenetic inheritance, and cancer. In the bacteriumSalmonella entericaserovar Typhimurium, 5′ tRNA halves ending in 2′,3′ cyclic phosphate are proposed to bind the RtcR transcriptional activator, resulting in transcription of an RNA ...
Xinguo Chen, Sandra L. Wolin
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tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy
Frontiers in Pharmacology, 2020 Transfer RNAs (tRNAs) are abundantly expressed, small non-coding RNAs that have long been recognized as essential components of the protein translation machinery.
Jun Cao, Douglas B. Cowan, Da-Zhi Wang
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Role of tRNA-derived small RNAs(tsRNAs) in the diagnosis and treatment of malignant tumours
Cell Communication and Signaling, 2023 Malignant tumours area leading cause of death globally, accounting for approximately 13% of all deaths. A detailed understanding of the mechanism(s) of the occurrence and development of malignant tumours and identification of relevant therapeutic targets
Mingwen Mao +3 more
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Frontiers in Molecular Biosciences, 2021 In the past 2 decades, the discovery of a new class of small RNAs, known as tRNA-derived fragments (tRFs), shed light on a new layer of regulation implicated in many biological processes.
Cristiane S. Alves, Fabio T. S. Nogueira
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The Small RNA Component of Arabidopsis thaliana Phloem Sap and Its Response to Iron Deficiency
Plants, 2023 In order to discover sRNA that might function during iron deficiency stress, RNA was prepared from phloem exudates of Arabidopsis thaliana, and used for RNA-seq. Bioanalyzer results indicate that abundant RNA from phloem is small in size—less than 200 nt.
Ahmet Bakirbas +2 more
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