tRNA-derived small RNAs: Mechanisms and potential roles in cancers [PDF]
Genes and Diseases, 2022 Transfer RNAs (tRNAs) are essential for protein synthesis. Mature or pre-tRNAs may be cleaved to produce tRNA-derived small RNAs (tsRNAs). tsRNAs, divided into tRNA-derived stress-induced RNA (tiRNAs) and tRNA-derived fragments (tRFs), play versatile ...
Yao Wang +5 more
doaj +2 more sources
Computational Approaches to tRNA-Derived Small RNAs
Non-Coding RNA, 2017 tRNA-derived small RNAs (tDRs) are a group of small, non-coding RNAs derived from transfer RNAs (tRNAs). They can be classified as tRNA halves and tRNA-derived small RNA fragments (tRFs). Accumulating experimental evidence suggests their functional roles
Wei-Lin Xu +4 more
doaj +3 more sources
The function of tRNA-derived small RNAs in cardiovascular diseases [PDF]
Molecular Therapy: Nucleic AcidstRNA-derived small RNAs (tsRNAs) constitute a subgroup of small noncoding RNAs (ncRNAs) originating from tRNA molecules. Their rich content, evolutionary conservatism, high stability, and widespread existence makes them significant in disease research ...
Yan Zhao +8 more
doaj +2 more sources
tRNA-Derived Small RNAs: A Novel Regulatory Small Noncoding RNA in Renal Diseases [PDF]
Kidney Diseases, 2023 Background: tRNA-derived small RNAs (tsRNAs) are an emerging class of small noncoding RNAs derived from tRNA cleavage. Summary: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including
Dan Li +6 more
doaj +2 more sources
Deciphering the tRNA-derived small RNAs: origin, development, and future [PDF]
Cell Death and Disease, 2021 Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu +5 more
doaj +2 more sources
tRNA-derived small RNAs in ocular neovascular diseases: A systematic review [PDF]
Non-coding RNA ResearchOcular neovascular diseases (ONDs) are a leading cause of global blindness. While current anti-vascular endothelial growth factor (VEGF) treatments have revolutionized management, their efficacy is constrained by issues such as non-response, resistance ...
Tian-yi Liu +6 more
doaj +2 more sources
tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy
Frontiers in Pharmacology, 2020 Transfer RNAs (tRNAs) are abundantly expressed, small non-coding RNAs that have long been recognized as essential components of the protein translation machinery.
Jun Cao, Douglas B. Cowan, Da-Zhi Wang
doaj +3 more sources
Distinct Stress‐Dependent Signatures of Cellular and Extracellular tRNA‐Derived Small RNAs [PDF]
Advanced Science, 2022 The cellular response to stress is an important determinant of disease pathogenesis. Uncovering the molecular fingerprints of distinct stress responses may identify novel biomarkers and key signaling pathways for different diseases.
Guoping Li +18 more
doaj +2 more sources
tRNA-derived small RNAs: their role in the mechanisms, biomarkers, and therapeutic strategies of colorectal cancer [PDF]
Journal of Translational MedicineColorectal cancer (CRC) is the third most prevalent malignancy and the second leading cause of cancer-related mortality worldwide, with an increasing shift towards younger age of onset.
Bo Zhang, Yanru Pan, Zhe Li, Kefeng Hu
doaj +2 more sources
The Therapeutic Potential of tRNA-derived Small RNAs in Neurodegenerative Disorders [PDF]
Aging Dis, 2022 Chuang Wang, Haihua Tian
exaly +2 more sources