Results 41 to 50 of about 1,394 (153)

Characteristics of tRNA-Derived Small RNAs and microRNAs Associated with Immunocompromise in an Intrauterine Growth-Restricted Pig Model

Animals, 2022
Intrauterine growth restriction (IUGR) is an important cause of newborn morbidity and mortality in mammals. Transfer RNA-derived small RNA (tsRNA) has become an emerging non-coding RNA in recent years.
Jianfeng Ma, Mailin Gan, Jingyun Chen, Lei Chen, Ye Zhao, Yan Zhu, Lili Niu, Shunhua Zhang, Yanzhi Jiang, Zongyi Guo, Jinyong Wang, Li Zhu, Linyuan Shen   +12 more
doaj   +1 more source

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder [PDF]

Science, 2016
Offspring affected by sperm small RNAsPaternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse sperm.
Chen, Qi, Yan, Menghong, Cao, Zhonghong, Li, Xin, Zhang, Yunfang, Shi, Junchao, Feng, Gui-hai, Peng, Hongying, Zhang, Xudong, Zhang, Ying, Qian, Jingjing, Duan, Enkui, Zhai, Qiwei, Zhou, Qi   +13 more
openaire   +4 more sources

tRNA-derived small RNA, tsRNA-5017b, as a novel biomarker for predicting severity in severe fever with thrombocytopenia syndrome

Microbiology Spectrum
tRNA-derived small RNAs (tsRNAs) represent a novel class of highly conserved non-coding RNAs that play crucial roles in various cellular processes, including cell proliferation and the initiation of viral reverse transcription.
Wanying Zhang, Jiawei Feng, Shixing Chen, Na Cao, Shuo Ma, Jiale Li, Linyan Gong, Haiyan Gao, Tianyang Liu, Xiaofeng Cheng, Hongpan Xu, Yuxin Chen   +11 more
doaj   +1 more source

Emerging role of a novel small non-coding regulatory RNA: tRNA-derived small RNA [PDF]

ExRNA, 2019
The discovery of small non-coding RNAs, such as miRNA and piRNA, has dramatically changed our understanding of the role RNA plays in organisms. Recent studies show that a novel small non-coding RNA generated from cleavage of tRNA or pre-tRNA, called tRNA-
Fangfang Jin, Zhigang Guo
doaj   +1 more source

tsRNA: A Promising Biomarker in Breast Cancer

Journal of Cancer
tRNA-derived small RNAs (tsRNAs) are a novel class of non-coding small RNAs, generated from specific cleavage sites of tRNA or pre-tRNA. tsRNAs can directly participate in RNA silencing, transcription, translation, and other processes. Their dysregulation is closely related to the occurrence and development of various cancers.
Huang, Ting, Zhao, Yuexin, Jiang, Guoqin, Yang, Zhixue   +3 more
openaire   +2 more sources

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Research progress of tsRNAs in kidney diseases

PeerJ
Transfer RNA-derived small RNAs (tsRNAs) are a class of regulatory non-coding RNAs generated through enzymatic cleavage of precursor or mature tRNAs. In recent years, tsRNAs have garnered growing interest in nephrology due to their diverse biological functions and potential clinical significance.
Wang, Jialing, Wang, Yanzhe, Li, Fengqin, Xie, Xinmiao, Chen, Xinyue, Wu, Tong, Wang, Xiaoxia   +6 more
openaire   +2 more sources

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Chronic lymphocytic leukemia (CLL) is the most common human leukemia. We identified two members of the tRNA-derived small RNA (tsRNA) family, ts-3676 and ts-4521 , both inactivated in CLL and lung cancer.
Pekarsky, Yuri, Balatti, Veronica, Palamarchuk, Alexey, Rizzotto, Lara, Veneziano, Dario, Nigita, Giovanni, Rassenti, Laura Z, Pass, Harvey I, Kipps, Thomas J, Liu, Chang-Gong, Croce, Carlo M   +10 more
openaire   +4 more sources

Transfer- or ‘transmission’-RNA fragments? The roles of tsRNAs in the reproductive system

Molecular Human Reproduction, 2021
ABSTRACTTransfer-RNAs (tRNAs) help ribosomes decode mRNAs and synthesize proteins; however, tRNA fragments produced under certain conditions, known as tRNA-derived small RNAs (tsRNAs), have been found to play important roles in pathophysiological processes. In the reproductive system, tsRNAs are abundant in gametes and embryos and at the maternal–fetal
Hui-Min Li, Xia Tan, Shun Zhang, Jun Yao, Hong-Gang Li   +4 more
openaire   +2 more sources