Results 61 to 70 of about 1,394 (153)

The Significance of the Regulation Between tRF‐31‐U5YKFN8DYDZDD and BMPER in the Pathogenesis of Gastric Cancer (GC)

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT tsRNAs are a kind of small non‐coding single‐stranded RNA, which play an important role in many kinds of tumours. Previous studies have identified that tRF‐31‐U5YKFN8DYDZDD can be used as a novel tumour biomarker for the diagnosis and prognosis of gastric cancer (GC).
Yuejiao Huang, Xun Li, Yu Zhang, Xinliang Gu, Shiyi Qin, Ming Zheng, Han Wang, Shaoqing Ju   +7 more
wiley   +1 more source

Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis

Molecular Cancer, 2019
tRNA-derived small RNA (tsRNA) is a novel regulatory small non-coding RNA and participates in diverse physiological and pathological processes. However, the presence of tsRNAs in exosome and their diagnostic potential remain unclear.
Lei Zhu, Jiao Li, Youling Gong, Qingbin Wu, Shuangyan Tan, Dan Sun, Xiaomin Xu, Yuanli Zuo, Yun Zhao, Yu-Quan Wei, Xia-Wei Wei, Yong Peng   +11 more
doaj   +1 more source

Pathological significance of tRNA-derived small RNAs in neurological disorders

Neural Regeneration Research, 2020
Non-coding RNAs (ncRNAs) are a type of RNA that is not translated into proteins. Transfer RNAs (tRNAs), a type of ncRNA, are the second most abundant type of RNA in cells.
Chuan Qin, Pei-Pei Xu, Xin Zhang, Chao Zhang, Chang-Bin Liu, De-Gang Yang, Feng Gao, Ming-Liang Yang, Liang-Jie Du, Jian-Jun Li   +9 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

tsRBase: a comprehensive database for expression and function of tsRNAs in multiple species

Nucleic Acids Research, 2020
Abstract tRNA-derived small RNAs (tsRNAs) are a class of novel small RNAs, ubiquitously present in prokaryotes and eukaryotes. It has been reported that tsRNAs exhibit spatiotemporal expression patterns and can function as regulatory molecules in many biological processes.
Yuanli Zuo, Lei Zhu, Zhixin Guo, Wenrong Liu, Jiting Zhang, Zhen Zeng, Qingbin Wu, Jian Cheng, Xin Fu, Yang Jin, Yun Zhao, Yong Peng 0003   +11 more
openaire   +2 more sources

Biofluid‐specific variations in circulating 5′ transfer RNA fragments during ictal and interictal states in experimental temporal lobe epilepsy

Epilepsia, Volume 67, Issue 7, Page 3803-3814, July 2026.
Abstract Objective Circulating small noncoding RNAs represent potential biomarkers of temporal lobe epilepsy (TLE). Recently, two transfer RNA fragments (tRFs), 5′tRF Glu‐CTC and Gly‐GCC, were found to be elevated in plasma samples collected in advance of a seizure in TLE patients, suggesting they may serve as potential wet biomarkers of seizure risk ...
Marie Soukupova, Elena Perez Morrissey, Annunziata Guarino, Pietro Marino, Cristiana Pareo, Nicolò Birtolo, Saad Zaheer, Rachel Stewart, Ina Woods, Felix Rosenow, Hajo Hamer, Péter Körtvélyessy, Shona Pfeiffer, David C. Henshall, Jochen H. M. Prehn, Michele Simonato   +15 more
wiley   +1 more source

CLTDA: Identifying Associations Between tsRNAs and Diseases Based on Contrastive Learning

Big Data Mining and Analytics
Increasing evidences have highlighted the significant association between tsRNAs and diseases. Predicting potential tsRNA-disease associations based on computational methods can effectively reduce human and resource consumption.
Wei Lan, Wenyi Chen, Chunling Li, Qingfeng Chen, Wei Peng, Yi-Ping Phoebe Chen, Xiaoshu Zhu   +6 more
doaj   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs

WIREs RNA, Volume 17, Issue 4, July/August 2026.
NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind, Samira K. Bell, Carol S. Lutz   +2 more
wiley   +1 more source

tsRNA in head and neck tumors: Opportunities and challenges in the field

Non-coding RNA Research
Transfer RNA-derived small RNAs (tsRNAs) are a newly recognized class of small non-coding RNAs that are implicated in a variety of cancers, including head and neck tumors. Studies have identified tsRNAs with differential expression profiles in head and neck malignancies, highlighting their potential as biomarkers for diagnosis and prognosis. Functional
Zhuo wu, Yufeng Xu, Changzeng Zhou, Yongbo Zhang, Jingjing Chen   +4 more
openaire   +3 more sources