Results 81 to 90 of about 1,394 (153)

Identification of serum tRNA-derived small RNAs biosignature for diagnosis of tuberculosis

Emerging Microbes and Infections
The tRNA-derived small RNAs (tsRNAs) are a new class of non coding RNAs, which are stable in body fluids and can be used as potential biomarkers for disease diagnosis.
Zikun Huang, Qing Luo, Cuifen Xiong, Haiyan Zhu, Chao Yu, Jianqing Xu, Yiping Peng, Junming Li, Aiping Le   +8 more
doaj   +1 more source

RNA Structure Design Improves Activity and Specificity of trans-Splicing-Triggered Cell Death in a Suicide Gene Therapy Approach

Molecular Therapy: Nucleic Acids, 2018
Spliceosome-mediated RNA trans-splicing enables correction or labeling of pre-mRNA, but therapeutic applications are hampered by issues related to the activity and target specificity of trans-splicing RNA (tsRNA).
Sushmita Poddar, Pei She Loh, Zi Hao Ooi, Farhana Osman, Joachim Eul, Volker Patzel   +5 more
doaj   +1 more source

Plasma tsRNA Signatures Serve as a Novel Biomarker for Bladder Cancer

Cancer Science
ABSTRACTBladder cancer (BLCA) is one of the most common tumors of the urinary tract. The diagnosis of BLCA is mostly by invasive tests, which are damaging and unsuitable for early screening. Current non‐invasive diagnostic modalities are insufficient in sensitivity and specificity.
Xinyan Xu, Jinbang Chen, Ming Bai, TianYao Liu, Shoubin Zhan, Jiazheng Li, YuanChun Ma, Yulin Zhang, Liming Wu, Zihan Zhao, Siyang Liu, Xi Chen, Feng Fang, Hongqian Guo, Ying Sun, Rong Yang   +15 more
openaire   +2 more sources

Oncogenic-tsRNA: A novel diagnostic and therapeutic molecule for cancer clinic

Journal of Cancer
tsRNA (tRNA-derived small RNA) is derived from mature tRNA or precursor tRNA (pre-tRNAs). It is lately found that tsRNA's aberrant expression is associated with tumor occurrence and development, it may be used a molecule of diagnosis and therapy. Based on the cleavage position of pre-tRNAs or mature tRNAs, tsRNAs are classified into two categories ...
Chen, Lin, Wu, Yao, Tang, Qi, Tang, Faqing   +3 more
openaire   +2 more sources

Ribonuclease Inhibitor 1 (RNH1) Regulates Sperm tsRNA Generation for Paternal Inheritance through Interacting with Angiogenin in the Caput Epididymis

Antioxidants
Environmental stressors can induce paternal epigenetic modifications that are a key determinant of the intergenerational inheritance of acquired phenotypes in mammals. Some of them can affect phenotypic expression through inducing changes in tRNA-derived
Zhuoyao Ma, Ningyuan Tang, Ruiyan Zhang, Hanyu Deng, Kexin Chen, Yue Liu, Zhide Ding   +6 more
doaj   +1 more source

TsRNA-49-73-Glu-CTC: A promising serum biomarker in non-small cell lung cancer.

PLoS ONE
ObjectiveLung cancer has the highest incidence and mortality rates globally, with the majority of cases classified as non-small cell lung cancer (NSCLC). Due to the absence of specific tumor biomarkers, most lung cancer cases are diagnosed at an advanced
Chenyu Li, Shenjie Zhong, Juan Chen, Xiaofeng Mu   +3 more
doaj   +1 more source

Osteogenic Effect of tsRNA-10277-Loaded Exosome Derived from Bone Mesenchymal Stem Cells on Steroid-Induced Osteonecrosis of the Femoral Head

Drug Design, Development and Therapy, 2020
Shanhong Fang,1,* Tianmin He,2,* Jiarun Jiang,3 Yongfeng Li,1 Peng Chen1 1Department of Orthopedics, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, People’s Republic of China; 2Department of Vascular Surgery, The First ...
Fang S, He T, Jiang J, Li Y, Chen P
doaj  

tRNA-derived small RNAs in pulmonary diseases: Regulatory functions and clinical prospects

Pharmacological Research
Transfer RNA-derived small RNAs (tsRNAs) are evolutionarily conserved regulatory molecules produced by stress-responsive endonucleases that cleave mature tRNAs or their precursors.
Ye Wang, Xiaoyu Song, Ge Ma, Xing Liu, Cong Gan, Apeng Chen, Man Tian, Xu Han   +7 more
doaj   +1 more source

Screening and validation of tsRNAs associated with lung adenocarcinoma

陆军军医大学学报
Objective‍　To explore the roles of transfer RNA-derived small RNAs （tsRNAs） in the oncogenesis and progression of lung adenocarcinoma by analyzing the differential expression of tsRNAs in lung adenocarcinoma and the relationship between the expression levels of tsRNAs in lung adenocarcinoma and the prognosis of patients in order to further screen and ...
LU Chunli, SHAN Yifan, XIE Weijia
openaire   +1 more source

Serum tsRNA as a novel molecular diagnostic biomarker for lupus nephritis

Clinical and Translational Medicine, 2022
Xiaoshan Zhang, Ping Yang, Adeel Khan, Dongjie Xu, Shanshan Chen, Junbin Zhai, Bin Zhang, Tao Xiong, Yanbo Wang, Zhiyang Li   +9 more
openaire   +3 more sources