Results 71 to 80 of about 1,394 (153)

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

Advanced Science, Volume 13, Issue 29, 22 May 2026.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang, Wenjing Zhang, Hang Wei, Shiyan Liu, Junliang Shang, Weijie Gong, Hanwen Cheng, Xiujuan Lei, Yuhui Kou, Baoguo Jiang   +9 more
wiley   +1 more source

Unveiling the role of tRNA-derived small RNAs in MAPK signaling pathway: implications for cancer and beyond

Frontiers in Genetics
tRNA-derived small RNAs (tsRNAs) are novel small non-coding RNAs originating from mature or precursor tRNAs (pre-tRNA), typically spanning 14 to 30 nt.
Qurui Wang, Qinyuan Huang, Xiaowei Ying, Jinze Shen, Shiwei Duan, Shiwei Duan   +5 more
doaj   +1 more source

A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring

Obesity Reviews, Volume 27, Issue 5, May 2026.
ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick, Victorio Bambini Junior, Neil Dawson, Cheryl A. Hawkes   +3 more
wiley   +1 more source

Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut‐Liver Bacterial Translocation and Pro‐Tumorigenic Processes

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Bacterial extracellular vesicles (EVs) are emerging mediators of host–microbe communication; however, their role in human disease remains unclear. Here, we identify two bacterial small tRNAs (tsRNAs) enriched in gut commensal Klebsiella pneumoniae‐derived EVs (KpEVs) that are markedly elevated in the serum of patients with hepatocellular ...
Shogo Tsubaki, Sho Nashimoto, Rika Tanaka, Touya Toyomoto, Hiroyasu Tsutsuki, Ken Kato, Jun Nakayama, Kiminori Kimura, Kazuki Oshima, Yusuke Yamamoto, Takuji Okusaka, Minoru Esaki, Nobuhiro Kawai, Nobuyuki Ota, Yusuke Yoshioka, Takahiro Ochiya, Yoshimasa Saito, Tomohiro Sawa, Katsuto Hozumi, Juntaro Matsuzaki, Hitoshi Tsugawa   +20 more
wiley   +1 more source

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, Volume 59, Issue 4, April 2026.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Circulating exosomal tsRNAs: Potential biomarkers for large artery atherosclerotic stroke superior to plasma tsRNAs

Clinical and Translational Medicine, 2023
Kaiying Yang, Qi Xiao, Kun Wang, Jie Zhao, Rongyao Hou, Xudong Pan, Xiaoyan Zhu   +6 more
openaire   +3 more sources

Small RNA sequencing reveals a novel tsRNA-26576 mediating tumorigenesis of breast cancer

Cancer Management and Research, 2019
Jun Zhou,1 Fang Wan,1 Yike Wang,1 Jinpei Long,1 Xuan Zhu2,31Department of Surgery, The Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China; 2The Second Affiliated Hospital ...
Zhou J, Wan F, Wang Y, Long J, Zhu X
doaj  

Systematic and Comprehensive Analysis of tRNA-Derived Small RNAs Reveals Their Potential Regulatory Roles and Clinical Relevance in Sarcoidosis

Journal of Inflammation Research, 2023
Min Zhao, Chang Tian, Xin Di, Shan Cong, Yingshu Cao, Xijia Zhou, Ke Wang Department of Respiratory and Critical Care Medicine, the Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Ke Wang, The Second ...
Zhao M, Tian C, Di X, Cong S, Cao Y, Zhou X, Wang K   +6 more
doaj  

Co-targeting of glial activation and inflammation by tsRNA-Gln-i-0095 for treating retinal ischemic pathologies

Cell Communication and Signaling
Ischemic retinopathies are the major causes of blindness, yet effective early-stage treatments remain limited due to an incomplete understanding of the underlying molecular mechanisms.
Ying Zhang, Yan Ma, Yu-Ke Ji, Yi-Fei Jiang, Duo Li, Wan Mu, Mu-Di Yao, Jin Yao, Biao Yan   +8 more
doaj   +1 more source

tsRNADisease: a manually curated database of tsRNAs associated with human disease

Journal of Genetics and Genomics
tRNA-derived small RNAs (tsRNAs), as a class of regulatory small noncoding RNA, have been implicated in a wide variety of human diseases. Large amounts of tsRNA-disease associations have been identified in recent years from accumulating studies. However, repositories for cataloging the detailed information on tsRNA-disease associations are scarce.
Hui Yang, Shaoying Zhu, Huijun Wei, Wei Huang, Qi Chen, Yungang He, Kun Lv, Zhen Yang   +7 more
openaire   +2 more sources