Results 41 to 50 of about 45,835 (229)
Role of tRNA-derived small RNAs(tsRNAs) in the diagnosis and treatment of malignant tumours
Cell Communication and Signaling, 2023 Malignant tumours area leading cause of death globally, accounting for approximately 13% of all deaths. A detailed understanding of the mechanism(s) of the occurrence and development of malignant tumours and identification of relevant therapeutic targets
Mingwen Mao +3 more
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tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy
Frontiers in Pharmacology, 2020 Transfer RNAs (tRNAs) are abundantly expressed, small non-coding RNAs that have long been recognized as essential components of the protein translation machinery.
Jun Cao, Douglas B. Cowan, Da-Zhi Wang
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Journal of Orthopaedic Surgery and Research, 2023 Osteoarthritis (OA) is a degenerative disease. It is common in middle-aged and elderly people and is one of the main causes of disability. Currently, the etiology of OA is unclear, and no specific biomarkers for the diagnosis of OA have been identified ...
Yingchen Ni +4 more
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Signature of circulating small non-coding RNAs during early fracture healing in mice
Bone Reports, 2022 Fracture healing is a complex process with multiple overlapping metabolic and differentiation phases. Small non-coding RNAs are involved in the regulation of fracture healing and their presence in circulation is under current interest due to their ...
Matthieu Bourgery +9 more
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Serum tRNA-derived fragments as potential biomarkers in children with acute intussusception. [PDF]
Archives of Medical Science, 2020 IntroductionIntestinal ischemia–reperfusion injury (I/R) can occur during pediatric intussusception, and any delay in diagnosis or treatment can lead to loss of intestinal viability that requires bowel resection. The aim of the present study was to investigate whether transfer ribonucleic acid (tRNA)–derived fragments (tRFs) can serve as candidate ...
Lian Zhao, Wei Chen, Wan-liang Guo
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Cell Reports, 2013 Transfer RNA (tRNA) fragmentation in response to stress conditions has been described in many organisms. tRNA fragments have been found in association with small interfering RNA (siRNA) components, but the biological role of these interactions remains ...
Zeljko Durdevic +4 more
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Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
A comprehensive repertoire of tRNA-derived fragments in prostate cancer
Oncotarget, 2016 Prostate cancer (PCa) is the most common cancer among men in developed countries. Although its genetic background is thoroughly investigated, rather little is known about the role of small non-coding RNAs (sncRNA) in this disease. tRNA-derived fragments (tRFs) represent a new class of sncRNAs, which are present in a broad range of species and have been
Olvedy, Michael +5 more
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Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
tRNA-Derived Fragments as Novel Predictive Biomarkers for Trastuzumab-Resistant Breast Cancer
Cellular Physiology and Biochemistry, 2018 Background/Aims: Resistance to trastuzumab remains a common challenge to HER-2 positive breast cancer. Up until now, the underlying mechanism of trastuzumab resistance is still unclear.
Chunxiao Sun +15 more
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