Results 31 to 40 of about 45,835 (229)
Transfer RNA-Derived Fragments, the Underappreciated Regulatory Small RNAs in Microbial Pathogenesis
Frontiers in Microbiology, 2021 In eukaryotic organisms, transfer RNA (tRNA)-derived fragments have diverse biological functions. Considering the conserved sequences of tRNAs, it is not surprising that endogenous tRNA fragments in bacteria also play important regulatory roles.
Zhongyou Li, Bruce A. Stanton
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Conserved and highly expressed tRNA derived fragments in zebrafish [PDF]
BMC Molecular Biology, 2015 Small non-coding RNAs (sncRNAs) are a class of transcripts implicated in several eukaryotic regulatory mechanisms, namely gene silencing and chromatin regulation. Despite significant progress in their identification by next generation sequencing (NGS) we are still far from understanding their full diversity and functional repertoire.Here we report the ...
Soares, Ana Raquel +6 more
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Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
Biomarker Research, 2020 The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers.
Yue Zhang, Huizhu Qian, Jing He, Wen Gao
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CHIMIA, 2019 Besides their medical importance, the parasitic protozoan Trypanosoma brucei and its relatives are experimentally highly accessible model systems for many cell biological processes.
Shikha Shikha +3 more
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Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases [PDF]
Genomics & Informatics, 2015 tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles
Yu Fu +3 more
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Memorias do Instituto Oswaldo Cruz, 2012 Small non-coding RNAs derived from transfer RNAs have been identified as a broadly conserved prokaryotic and eukaryotic response to stress. Their presence coincides with changes in developmental state associated with gene expression regulation.
Larissa Reifur +8 more
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Expression profile of tRNA‑derived fragments in pancreatic cancer
Oncology Letters, 2019 Pancreatic cancer is a deadly disease, the deadliest of all the solid tumors; the 5-year survival rate of patients with this disease is ~8%. Previously, high-throughput sequencing has led to the discovery of novel small non-coding RNAs, also known as transfer RNA-derived fragments (tRFs).
Jin, Lei, Zhu, Chunfu, Qin, Xihu
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The multifaceted regulatory potential of tRNA-derived fragments [PDF]
Non-coding RNA Investigation, 2017 tRNAs have been discovered in the late 1950-ies of the last century and have subsequently been characterized biochemically, genetically and structurally as amino-acid delivering molecules for protein biosynthesis. First reports of stable tRNA-derived cleavage products have been reported in the late 1970-ies (1), but at that time they were mostly ...
Cristodero, Marina, Polacek, Norbert
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Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
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Pathological significance of tRNA-derived small RNAs in neurological disorders
Neural Regeneration Research, 2020 Non-coding RNAs (ncRNAs) are a type of RNA that is not translated into proteins. Transfer RNAs (tRNAs), a type of ncRNA, are the second most abundant type of RNA in cells.
Chuan Qin +9 more
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