The Roles of tRNA-Derived Fragments in Cancer: Updates and Perspectives. [PDF]
Int J Mol SciThe non-coding RNAs (ncRNAs) have been reported in numerous studies, and their significant roles in several diseases have been verified subsequently. tRNA-derived fragments (tRFs) are a newly discovered class of small ncRNAs which are produced by mature or precursor tRNAs.
Geng J, Sun Z, Li H.
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Protocol for detection of tRNA-derived fragments in cells, tissues, and plasma. [PDF]
STAR ProtoctRNA-derived fragments (tRFs) are frequently dysregulated in cancers, and approaches for the detection of tRFs within biological samples are vital for their expression analysis and functional exploration. Here, we present a protocol for detecting tRFs using a modified TaqMan quantitative real-time PCR (qRT-PCR)-based technique, Dumbbell-PCR (Db-PCR ...
Yu M, Liu P, Lu Y.
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tRNA‐derived fragments are promising biomarkers for screening of early colorectal cancer [PDF]
MedComm, 2023 Yanqi Dang +5 more
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Extracellular tRNAs and tRNA-derived fragments [PDF]
RNA Biology, 2020 Fragmentation of tRNAs generates a family of small RNAs collectively known as tRNA-derived fragments. These fragments vary in sequence and size but have been shown to regulate many processes involved in cell homoeostasis and adaptations to stress. Additionally, the field of extracellular RNAs (exRNAs) is rapidly growing because exRNAs are a promising ...
Juan Pablo Tosar, Alfonso Cayota
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Expression profiles and function prediction of tRNA-derived fragments in glioma. [PDF]
BMC Cancer, 2023 Abstract Background Glioblastoma (GBM) is the most aggressive malignant primary brain tumor. The transfer RNA-derived fragments (tRFs) are a new group of small noncoding RNAs, which are dysregulated in many cancers.
Wei D +6 more
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Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves
mBio, 2023 tRNA-derived fragments have been reported in many different organisms and have diverse cellular roles, such as regulating gene expression, inhibiting protein translation, silencing transposable elements, and modulating cell proliferation.
Manu Sharma +3 more
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tRNA-Derived Fragments as Biomarkers in Bladder Cancer. [PDF]
Cancers (Basel)Bladder cancer (BC) diagnosis is reliant on cystoscopy, an invasive procedure associated with urinary tract infections. This has sparked interest in identifying noninvasive biomarkers in body fluids such as blood and urine. A source of biomarkers in these biofluids are extracellular vesicles (EVs), nanosized vesicles that contain a wide array of ...
Strømme O +5 more
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tRNA-Derived Small RNAs: A Novel Regulatory Small Noncoding RNA in Renal Diseases
Kidney Diseases, 2023 Background: tRNA-derived small RNAs (tsRNAs) are an emerging class of small noncoding RNAs derived from tRNA cleavage. Summary: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including
Dan Li +6 more
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tRFs and tRNA Halves: Novel Cellular Defenders in Multiple Biological Processes
Current Issues in Molecular Biology, 2022 tRNA fragments derived from angiogenin or Dicer cleavage are referred to as tRNA-derived fragments (tRFs) and tRNA halves. tRFs and tRNA halves have been identified in both eukaryotes and prokaryotes and are precisely cleaved at specific sites on either ...
Jiani Hou +3 more
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Arabidopsis tRNA-derived fragments as potential modulators of translation [PDF]
RNA Biology, 2020 Transfer RNA-derived fragments (tRFs) exist in all branches of life. They are involved in RNA degradation, regulation of gene expression, ribosome biogenesis. In archaebacteria, kinetoplastid, yeast, and human cells, they were also shown to regulate translation.
Lalande, Stéphanie +3 more
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