Results 181 to 190 of about 25,893 (220)
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International Pharmacopsychiatry, 2017
Among the four hypothalamic-releasing hormones (TRH, SRIF, LHRH, and MIF) with central nervous system actions and possibly with psychotropic properties, TRH is the one most systematically studied. Animal pharmacological data has confirmed the activity of TRH as a centrally acting agent with a widespread neurophysiological role independent of the ...
J C, Pecknold, T A, Ban
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Among the four hypothalamic-releasing hormones (TRH, SRIF, LHRH, and MIF) with central nervous system actions and possibly with psychotropic properties, TRH is the one most systematically studied. Animal pharmacological data has confirmed the activity of TRH as a centrally acting agent with a widespread neurophysiological role independent of the ...
J C, Pecknold, T A, Ban
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Pharmacopsychiatry, 2022
AbstractThyrotropin-releasing hormone (TRH), at doses lower than those needed to stimulate prolactin secretion directly, can almost completely antagonize dopamine inhibition of prolactin release. In normal men, prolactin increases 15 min following an i. v. bolus of 12.5 µg TRH
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AbstractThyrotropin-releasing hormone (TRH), at doses lower than those needed to stimulate prolactin secretion directly, can almost completely antagonize dopamine inhibition of prolactin release. In normal men, prolactin increases 15 min following an i. v. bolus of 12.5 µg TRH
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Protirelin (TRH) in Depression
Archives of General Psychiatry, 1974Protirelin (formally known as thyrotrophin releasing hormone [TRH]) was evaluated as a treatment in depression in two independent investigations using a similar protocol. The latter was designed so that some patients received three 600μg intravenous injections of protirelin early in their course and others received them toward the end of their course ...
L E, Hollister +4 more
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General and Comparative Endocrinology, 1984
The brains of goldfish and other teleosts contain high-affinity binding sites for [3H][3-methyl-His2]thyrotropin-releasing hormone [( 3H]MeTRH) which closely resemble TRH receptors in mammalian brain and pituitary gland in apparent dissociation constant (KD = 3-4 nM), in pharmacology for eight TRH analogs, and in exhibiting marked regional differences ...
D R, Burt, M A, Ajah
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The brains of goldfish and other teleosts contain high-affinity binding sites for [3H][3-methyl-His2]thyrotropin-releasing hormone [( 3H]MeTRH) which closely resemble TRH receptors in mammalian brain and pituitary gland in apparent dissociation constant (KD = 3-4 nM), in pharmacology for eight TRH analogs, and in exhibiting marked regional differences ...
D R, Burt, M A, Ajah
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Neuronal TRH synthesis: Developmental and circadian TRH mRNA levels
Biochemical and Biophysical Research Communications, 1988Peptide biosynthesis within a neuron involves several steps occurring at the soma and during its travel to the nerve terminal, where it accumulates to be released under stimulatory conditions. We have measured hypothalamic TRH and TRH mRNA during ontogeny and circadian cycle and observed that TRH mRNA variations are more prominent than TRH ones. On the
L, Covarrubias +4 more
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TRH-Gly, a precursor of TRH, alters GH secretion in acromegaly
Life Sciences, 1991We explored effects of a precursor of thyrotropin (TSH)-releasing hormone (TRH), TRH-Gly, on growth hormone (GH) secretion in acromegaly. Intravenous injection of TRH-Gly produced a profound increase in GH secretion in eight, decrease in two, and no response in five out of a total fifteen patients.
M, Mori +8 more
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The Pharmacokinetics of Thyrotropin-Releasing Hormone (TRH) and Deamido-TRH in the Rat*
Endocrinology, 1984The pharmacokinetics of TRH and its metabolite deamido-TRH (TRH-OH) were evaluated and compared. After a 60- to 90-min infusion of the appropriate peptide into rats, the MCR, half-life of disappearance (t 1/2), and volume of distribution were calculated. The MCR of TRH averaged 4 ml/min, whereas that of TRH-OH was 6.5 ml/min.
M, Safran +4 more
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TSH responsiveness to TRH (‘the TRH test’)—of no diagnostic value in depression
Human Psychopharmacology: Clinical and Experimental, 1988AbstractSerum free T4, free T3 and TSH (IRMA), along with TSH responsiveness to TRH (500 μg i.v.), were investigated in 12 patients, initially when severely depressed and again upon recovery, and in a group of age‐matched controls. The TSH response to TRH did not differ significantly between patients and controls, nor did it alter with treatment of ...
JA Vaughan +5 more
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TRH Immunoreactivity in Human Urine: Evidence for Dissociation from TRH
The Journal of Clinical Endocrinology & Metabolism, 1977Affinity chromatography columns containing rabbit antiserum to thyrotropin releasing hormone (TRH) were prepared and used to concentrate and investigate human urinary TRH imrnunoreactivity (TRH-IR). The recovery of synthetic TRH, [3H]TRH, and [125I]TRH when added to 20 to 25 ml of urine was 33 ± 9% (mean ± SE), 35 ± 8%, and 36 ± 6%, respectively ...
C H, Emerson +3 more
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Bleší trh Kolbenova. Trh jako prostor, trh jako organismus
2010My diploma thesis, Kolbenova "flea market" - market as a space, market as an organism, searches what is the nature of such a place as perceived by its visitors. I claim that the market can be taken to be an organism continuously reacting to incentives from both the market surroundings and the market participants.
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