Results 171 to 180 of about 12,599 (218)
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Reviews in Endocrine and Metabolic Disorders, 2016
The activity of the hypothalamus-pituitary-thyroid axis (HPT) is coordinated by hypophysiotropic thyrotropin releasing hormone (TRH) neurons present in the paraventricular nucleus of the hypothalamus. Hypophysiotropic TRH neurons act as energy sensors. TRH controls the synthesis and release of thyrotropin, which activates the synthesis and secretion of
Lorraine Jaimes-Hoy +2 more
exaly +3 more sources
The activity of the hypothalamus-pituitary-thyroid axis (HPT) is coordinated by hypophysiotropic thyrotropin releasing hormone (TRH) neurons present in the paraventricular nucleus of the hypothalamus. Hypophysiotropic TRH neurons act as energy sensors. TRH controls the synthesis and release of thyrotropin, which activates the synthesis and secretion of
Lorraine Jaimes-Hoy +2 more
exaly +3 more sources
Enzymic formation of TRH-OH from TRH by rat hypothalamus
Molecular and Cellular Endocrinology, 1980Specific radioimmunoassays for thyrotrophin-releasing hormone (TRH) and deamido-TRH (TRH-OH) were used to investigate the inactivation of TRH by subcellular fractions from rat hypothalamus. TRH-OH was rapidly formed from TRH by an amidase present only in the supernatant fraction at an optimum pH of 7.38; although TRH was degraded by the particulate ...
Theo Visser +2 more
exaly +3 more sources
Effects of TRH and TRH analogues on the central regulation of breathing in the rat
Acta Physiologica Scandinavica, 1983Respiratory activity was studied in rats during light halothane anesthesia. Thyrotropin releasing hormone (TRH) and two TRH analogues: the desamidated form (TRH‐OH) and γ‐butyrolactone‐γ‐carbonyl‐L‐histidyl‐L‐prolraamide citrate (DN 1417) were administered intracerebroventricularly.
D Lundberg, J Jonason
exaly +3 more sources
TRH and TRH Receptors in the Spinal Cord
Annals of the New York Academy of Sciences, 1989Over the past 12 years, substantial progress has been made in delineating the localization of TRH and TRH receptors in spinal cord. High concentrations of both the peptide and its receptor have been observed in the ventral horn in the region of the motoneurons and in the dorsal horn in the substantia gelatinosa. As noted, pharmacological effects of TRH
A, Winokur, S, Manaker, M S, Kreider
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Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly
Neuroscience Letters, 1995We studied the mechanism by which thyrotropin-releasing hormone (TRH)-Gly stimulated prolactin and thyrotropin (TSH) secretion in pituitary, using a pituitary mammotropic cell line, GH3 cells, and a cell line stably expressing a human TRH receptor (TRH-R).
M, Yamada +7 more
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Endocrinology, 1980
Chromatographic evidence for alternative pathways of TRH catabolism in the brain, involving either cleavage of the pGlu-His peptide bond or deamidation to form pGlu-His- Pro (TRH-OH), has been described. In the present study, RIAs for TRH and TRH-OH were used to determine if synthetic TRH is degraded by rodent brain tissue into TRH-OH and to evaluate ...
CHARLES H. EMERSON +3 more
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Chromatographic evidence for alternative pathways of TRH catabolism in the brain, involving either cleavage of the pGlu-His peptide bond or deamidation to form pGlu-His- Pro (TRH-OH), has been described. In the present study, RIAs for TRH and TRH-OH were used to determine if synthetic TRH is degraded by rodent brain tissue into TRH-OH and to evaluate ...
CHARLES H. EMERSON +3 more
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TRH and TRH-OH in the pancreas of adult and newborn rats
Life Sciences, 1985TRH and its metabolite TRH-OH have been measured by specific radioimmunoassays in acid extracts of pancreas in adults and developing rats. TRH and TRH-OH immunoreactivity had the same ontogenic pattern with a maximal concentration on day 4 followed by a progressive return towards adult levels on day 20.
Dutour, A. +4 more
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A radioimmunoassay for thyroliberin (TRH). comparison with a TRH radioreceptor assay
Neuroscience Letters, 1978A radioimmunoassay (RIA) for thyroliberin (TRH) is described which differs on several points from the previously published ones. A TRH antiserum was raised in rabbits against TRH coupled to a seed-globulin from the sun-flower; [(3)H]TRH was used as radioligand and precipitation of the antibody-antigen complex was achieved with polyethylene glycol (PEG).
D, Grouselle +2 more
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The Journal of Clinical Endocrinology & Metabolism, 1972
ABSTRACT After injection of 0.2 mg of TRH iv. concentrations of TRH were estimated in plasma, urine and saliva by T3-TRH bioassay in 5 euthyroid men. Plasma TRH was detectable (over 2 ng/ml) for 15 min and had a half-time of 5 min within the first 5 minutes, Urine TRH level was maximal at 15 min and was about 500-fold that in plasma.
J, Leppaluoto, P, Virkkunen, H, Lybeck
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ABSTRACT After injection of 0.2 mg of TRH iv. concentrations of TRH were estimated in plasma, urine and saliva by T3-TRH bioassay in 5 euthyroid men. Plasma TRH was detectable (over 2 ng/ml) for 15 min and had a half-time of 5 min within the first 5 minutes, Urine TRH level was maximal at 15 min and was about 500-fold that in plasma.
J, Leppaluoto, P, Virkkunen, H, Lybeck
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International Pharmacopsychiatry, 2017
Among the four hypothalamic-releasing hormones (TRH, SRIF, LHRH, and MIF) with central nervous system actions and possibly with psychotropic properties, TRH is the one most systematically studied. Animal pharmacological data has confirmed the activity of TRH as a centrally acting agent with a widespread neurophysiological role independent of the ...
J C, Pecknold, T A, Ban
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Among the four hypothalamic-releasing hormones (TRH, SRIF, LHRH, and MIF) with central nervous system actions and possibly with psychotropic properties, TRH is the one most systematically studied. Animal pharmacological data has confirmed the activity of TRH as a centrally acting agent with a widespread neurophysiological role independent of the ...
J C, Pecknold, T A, Ban
openaire +2 more sources