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Liver triacylglycerol lipases

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
The hallmark of obesity and one of the key contributing factors to insulin resistance, type 2 diabetes and cardiovascular disease is excess triacylglycerol (TG) storage. In hepatocytes, excessive accumulation of TG is the common denominator of a wide range of clinicopathological entities known as nonalcoholic fatty liver disease, which can eventually ...
Richard Lehner, Ariel D. Quiroga
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Triacylglycerol lipase in bovine erythrocytes

International Journal of Biochemistry, 1985
Acid lipase activity was found in the bovine erythrocyte ghosts, but little neutral or alkaline lipase activity was observed in the erythrocytes. The membrane-bound lipase showed a remarkable activity in the ghosts only after hemolysis. The membrane-bound lipase showed its maximum activity at pH 4.5, 38 degrees C, and it was stable below 40 degrees C ...
Koga Katsuya   +2 more
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Triacylglycerol lipases of the yeast

Frontiers in Biology, 2011
All eukaryotes including the yeast contain a lipid storage compartment which is named lipid particle, lipid droplet or oil body. Lipids accumulating in this subcellular fraction serve as a depot of energy and building blocks for membrane lipid synthesis. In the yeast, the major storage lipids are triacylglycerols (TGs) and steryl esters (SEs).
Karlheinz Grillitsch, Günther Daum
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The Regulation of Triacylglycerol Metabolism and Lipoprotein Lipase Activity

Advanced Biology, 2022
AbstractTriacylglycerol (TG) metabolism is tightly regulated to maintain a pool of TG within circulating lipoproteins that can be hydrolyzed in a tissue‐specific manner by lipoprotein lipase (LPL) to enable the delivery of fatty acids to adipose or oxidative tissues as needed.
Yi Wen, Yan Q. Chen, Robert J. Konrad
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Triacylglycerol Lipases in Adrenals and Testes of Rats

The Journal of Biochemistry, 1982
Triacylglycerol lipase activities in adrenals and testes of rats were measured and the properties of the enzymes were characterized. The enzymes were extracted from acetone-ether dried powder of the tissues and the crude extracts were applied to a heparin-Sepharose affinity column.
Nakaaki Ohsawa   +3 more
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Triacylglycerol metabolism and triacylglycerol lipase activities of cultured human skin fibroblasts

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980
The relative contribution of lipoproteins and free fatty acid to the cellular triacylglycerol content of cultured human fibroblasts was tested. Fibroblasts accumulated triacylglycerol in proportion to the molar ratio of free fatty acid (oleic acid) to albumin in the medium.
Edwin L. Bierman   +2 more
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Conversion of a Mono‐ and Diacylglycerol Lipase into a Triacylglycerol Lipase by Protein Engineering

ChemBioChem, 2015
AbstractDespite the fact that most lipases are believed to be active against triacylglycerides, there is a small group of lipases that are active only on mono‐ and diacylglycerides. The reason for this difference in substrate scope is not clear. We tried to identify the reasons for this in the lipase from Malassezia globosa. By protein engineering, and
Yonghua Wang   +5 more
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