Results 151 to 160 of about 11,188,116 (297)
Expedited Safety Reporting to Sponsors Through the Implementation of an Alert System for Clinical Trial Management at an Academic Medical Center: Retrospective Design Study. [PDF]
JMIR Med Inform, 2020 Park YR +7 more
europepmc +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Summons of freeholders to Frank's trial
This document is a legal writ issued by Samuel Dickinson and John Vining, two Justices of the Peace for Kent County. It outlines the commission assigned to James Wells, a constable, to summon several substantial freeholders, including Benjamin Chew ...
Kent County Court for the Trial of Negro Slaves
core +1 more source
National Student Trial Advocacy Competition
, 1996 - ATLAAssociation of Trial Lawyers of America National Student Trial Advocacy Competition Second Place 1996- ATLA Association of Trial Lawyers of America National Student Trial Advocacy Competition Second Place 1996Second PlaceSecond ...
core
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
International Journal of COPD, 2012 Richard Wood-Baker,1 David Reid,2 Andrew Robinson,3 E Haydn Walters11School of Medicine, University of Tasmania, Hobart; 2Department of Respiratory Medicine, Prince Charles Hospital, Brisbane; 3School of Nursing & Midwifery, University of ...
Wood-Baker R +3 more
doaj
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Detailed summary of Dick's trial in court
This document is a record of the proceedings of a special court held before John Caton and Caesar Rodney, Esquires, in Dover. The court convened to hear the trial of a Negro man named Dick who was accused of stealing two mares. The prosecution was led by
Kent County Court for the Trial of Negro Slaves
core +1 more source