Results 81 to 90 of about 11,188,116 (297)

Does it matter if clinicians recruiting for a trial don't understand what the trial is really about? Qualitative study of surgeons' experiences of participation in a pragmatic multi-centre RCT. [PDF]

, 2007
Background Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing.
Snowdon, Claire, Fairbank, Jeremy, Barker Karen, Fairbank Jeremy, Helen Frost, Fairbank, Jeremy C T, Featherstone Katie, Katie Featherstone, Jeremy Fairbank, Sue Ziebland, Frost, Helen, Snowdon, C, Snowdon Claire, Barker, K, Barker, Karen, Featherstone, Katie, Claire Snowdon, Ziebland, S, Ziebland Sue, Featherstone, K, Ziebland, Sue B, Frost Helen, Ziebland, Sue, Frost, H, Karen Barker   +24 more
core   +4 more sources

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

A phase II trial protocol of Tocilizumab in anti-TNF refractory patients with JIA-associated uveitis (the APTITUDE trial)

BMC Rheumatology, 2018
Background Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Children with JIA are at risk of intraocular inflammation (uveitis). In the initial stages of mild-moderate inflammation uveitis is asymptomatic.
Athimalaipet V. Ramanan, Andrew D. Dick, Ashley P. Jones, Catherine Guly, Ben Hardwick, Helen Hickey, Richard Lee, Andrew McKay, Michael W. Beresford, The APTITUDE Trial Management Group   +9 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

MANAGEMENT OF CLINICAL TRIALS [PDF]

The Lancet, 1988
  +5 more sources

Association between the subsequent benign prostate hyperplasia-related surgery risk and patients treated with Chinese herbal medicine: a population-based Taiwanese cohort study

BMC Complementary Medicine and Therapies
Background The association of Chinese herbal medicines (CHM) with the decreased risk of benign prostatic hyperplasia (BPH)-related surgery in patients with BPH is limited by the small sample size and short follow-up. We try to address this association in
Ming-Yen Tsai, Chun-Ting Liu, Yu-Sin Shen, Hao-Lun Luo, Tai-Lin Chen, Ying-Hsiu Shih, Yu-Tung Hung, Tzu-Ju Hsu, Fuu-Jen Tsai, Yung-Hsiang Chen   +9 more
doaj   +1 more source

Quality expectations and tolerance limits of trial master files (TMF) – Developing a risk-based approach for quality assessments of TMFs

GMS German Medical Science, 2015
This article addresses the question of when a trial master file (TMF) can be considered sufficiently accurate and complete: What attributes does the TMF need to have so that a clinical trial can be adequately reconstructed from documented data and ...
Hecht, Arthur, Busch-Heidger, Barbara, Gertzen, Heiner, Pfister, Heike, Ruhfus, Birgit, Sanden, Per-Holger, Schmidt, Gabriele B.   +6 more
doaj   +1 more source

The International Stroke Trial (IST): a randomized trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke

, 1997
BACKGROUND: Only a few small trials have compared antithrombotic therapy (antiplatelet or anticoagulant agents) versus control in acute ischaemic stroke, and none has been large enough to provide reliable evidence on safety or efficacy.
INTERNATIONAL STROKE TRIAL COLLABORATIVE GROUP, CAROLEI, ANTONIO   +1 more
core  

Simulation-based training of the rapid evaluation and management of acute stroke (stream) - a prospective single-arm multicenter trial [PDF]

, 2019
Introduction: Acute stroke care delivered by interdisciplinary teams is time-sensitive. Simulation-based team training is a promising tool to improve team performance in medical operations.
Kabbasch, Christoph, Doppler, Christopher E. J., Wollenweber, Frank A., Ringleb, Peter, Bohmann, Ferdinand O., Brekenfeld, Caspar, Alegiani, Anna, Onur, Özgür Abdullah, Bohmann, Ferdinand, Kurka, Natalia, Mengel, Annerose, Haeusler, Karl Georg, Koehler, Luzie, Guenther, Joachim, Onur, Oezguer A., Pfaff, Johannes, Häusler, Karl Georg, Herzberg, Moriz, Du Mesnil de Rochemont, Richard Klaus Frieder, Schubert, Charlotte, Köhler, Luzie Katharina, Nagel, Simon, Zickler, Philipp, Manser, Tanja, Wollenweber, Frank Arne, Ertl, Michael, Rostek, Peter, Berlis, Ansgar, Poli, Sven, Kellert, Lars, Du Mesnil de Rochemont, Richard, Gruber, Katharina, Doppler, Christopher Emanuel Julian, Pfeilschifter, Waltraud, Rai, Heike   +34 more
core   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source