Results 91 to 100 of about 11,188,116 (297)

The association between blood urea nitrogen to albumin ratio and 28-day ICU mortality in sepsis patients: a retrospective cohort study

European Journal of Medical Research
Background Sepsis remains a leading cause of mortality in intensive care unit (ICU) patients, with mortality rates up to 30%. While the Blood Urea Nitrogen (BUN) to Albumin ratio has been associated with outcomes in various conditions, the dose–response ...
Meiting Wu, Huijun Sun, Huiying Lv, Aiyong Zhu   +3 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

An 8-wk, randomized, double-blind, placebo-controlled clinical trial for the antidiabetic effects of hydrolyzed ginseng extract

Journal of Ginseng Research, 2014
Background: To investigate the antidiabetic effects of hydrolyzed ginseng extract (HGE) for Korean participants in an 8-wk, randomized, double-blinded, placebo-controlled clinical trial.
Soo-Hyun Park, Mi-Ra Oh, Eun-Kyung Choi, Min-Gul Kim, Ki-Chan Ha, Seung-Kwon Lee, Young-Gon Kim, Byung-Hyun Park, Dal-Sik Kim, Soo-Wan Chae   +9 more
doaj   +1 more source

The Beta Agonist Lung Injury TrIal (BALTI) : prevention trial protocol [PDF]

, 2011
Background: Acute lung injury complicates approximately 25-30% of subjects undergoing oesophagectomy. Experimental studies suggest that treatment with beta agonists may prevent the development of acute lung injury by decreasing inflammatory cell ...
Matthew W Cooke, Thickett, David R, Lamb, S. E. (Sallie E.), Thickett David R, David R Thickett, Cooke, Matthew (Professor of clinical systems design), Lamb, Sarah E, Perkins, Gavin D., Daniel Park, Mistry Dipesh, Fang Gao, Gao, Fang; id_orcid, Alderson, Derek, Cooke Matthew W, Gao Fang, Dipesh Mistry, Alderson Derek, Gao, Fang, Mistry, Dipesh, Park, Daniel P., Park Daniel, Cooke, Matthew W, Thickett, David R; id_orcid, Gates, Simon, Sarah E Lamb, Park, Daniel, Gavin D Perkins, Perkins, Gavin D, Simon Gates, Thickett, David R., Smith, F. Gao (Fang Gao), Gates Simon, Lamb Sarah E, Derek Alderson, Perkins Gavin D   +34 more
core   +3 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Missed PrEP opportunities and vulnerability to HIV during rifampicin-resistant tuberculosis treatment in South Africa

Frontiers in Public Health
BackgroundAdults receiving rifampicin-resistant TB (RR-TB) treatment have prolonged engagement with the health system, yet healthcare professionals frequently miss opportunities to promote HIV prevention—particularly pre-exposure prophylaxis (PrEP)—in ...
Adam Leonard, Kelly Lowensen, Kelly Lowensen, Elizabeth Di Giacomo, Brenice Duroseau, Ntombasekhaya Mlandu, Yakub Kadernani, Ricardo Arcêncio, Chakra Budhathoki, Chakra Budhathoki, Denise Evans, Denise Evans, Norbert Ndjeka, Norbert Ndjeka, Jason E. Farley, Jason E. Farley   +15 more
doaj   +1 more source

Clinical trial management: a profession in crisis? [PDF]

Trials, 2022
Mitchell EJ, Goodman K, Wakefield N, Cochran C, Cockayne S, Connolly S, Desai R, Hartley S, Lawton SA, Oatey K, Rhodes S, Savage JS, Taylor J, Youssouf NFJ, UK Trial Managers’ Network.   +14 more
europepmc   +1 more source

Role of clinical trial infrastructure in neglected disease Research and Development

, 2018
Thesis: S.M. in Management Research, Massachusetts Institute of Technology, Sloan School of Management, 2018.Cataloged from PDF version of thesis.Includes bibliographical references (pages 21-22).I investigate the role of country level clinical trial ...
Fry, Caroline Viola
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