Results 111 to 120 of about 11,188,116 (297)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Corrigendum: Decreased Risk of Anxiety in Diabetic Patients Receiving Glucagon-Like Peptide-1 Receptor Agonist: A Nationwide, Population-Based Cohort Study

Frontiers in Pharmacology, 2022
Wen-Hsuan Tsai, Fung-Chang Sung, Fung-Chang Sung, Fung-Chang Sung, Lu-Ting Chiu, Ying-Hsiu Shih, Ming-Chieh Tsai, Shu-I Wu, Shu-I Wu   +8 more
doaj   +1 more source

An integrated approach to improve clinical trial efficiency: Linking a clinical trial management system into the Research Integrated Network of Systems. [PDF]

J Clin Transl Sci, 2022
Sampson R, Shapiro S, He W, Denmark S, Kirchoff K, Hutson K, Paranal R, Forney L, McGhee K, Harvey J.   +9 more
europepmc   +1 more source

Pre-Trial Management of Expert Evidence in the Kilmore East Bushfire Proceeding

, 2016
This paper, the first in a series on the management of expert evidence during the Kilmore East bushfire proceeding, considers the pre-trial management of experts.
McKenzie, Simon
core  

Weight-management interventions in primary care: a pilot randomised controlled trial.

, 2009
BACKGROUND: There is a paucity of randomised controlled trials of weight management in primary care. AIM: To ascertain the feasibility of a full trial of a nurse-led weight-management programme in general practice.
Haslam, D, Nanchahal, K, Townsend, Joy, Haines, Andy, Wellings, Kaye, Letley, Louise, Nanchahal, Kiran, Townsend, J, Haines, A, Haslam, David, Wellings, K, Letley, L   +11 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Home versus outpatient administration of intravenous steroids for multiple-sclerosis relapses: a randomised controlled trial.

, 2006
BACKGROUND: Intravenous steroids are routinely used to treat disabling relapses in multiple sclerosis, and can be administered in an outpatient or home setting. We developed a rating scale that allowed us to compare the two strategies formally in a trial
Riazi, Afsane, Hobart, Jeremy, Heaney, Dominic, Porter, Bernadette, Watt, Hilary, Chataway, Jeremy, Thompson, Alan   +6 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The association between serum uric acid and homocysteine is mediated by metabolic risk factors

Scientific Reports
Previous studies have revealed a link between serum uric acid (SUA) and homocysteine (Hcy) levels, but it is unclear whether such relationship can be mediated by metabolic risk factors.
Linlin Zhao, Hui Zhou, Zhilin Xiao, Xinjian Qiu   +3 more
doaj   +1 more source

The Cure SMA Clinical Trial Experience Survey: A Study of Trial Participant Perspectives on Clinical Trial Management and Patient-Centric Management Practices. [PDF]

Neurol Ther, 2022
Peterson IS, Mazzella AJ, Belter LT, Curry MA, Cruz RE, Jarecki J.   +5 more
europepmc   +1 more source