Results 91 to 100 of about 6,757,255 (356)
Clinical trial budgeting approaches in Switzerland—a meta-research study
Background Conducting clinical trials is resource demanding. Mirroring challenges experienced elsewhere, clinical trials conducted in Switzerland often face overoptimistic budget estimations and insufficient funding, leading to trial discontinuation and ...
Klaus Ehrlich +24 more
core +1 more source
Research Report 2004–2005 [PDF]
, 2006 The National Health and Medical Research Council Clinical Trials Centre has the purpose of improving outcomes in health through clinical trials research.
NHMRC Clinical Trials Centre
core
A real-time dashboard of clinical trials for COVID-19
, 2021 Overzicht van clinical trials voor COVID-19 wereldwijd.
covid-trials
core
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono +7 more
wiley +1 more source
Opportunities and Challenges for Decentralized Clinical Trials: European Regulators' Perspective [PDF]
, 2022 Decentralized clinical trials (DCTs) have the potential to improve accessibility, diversity, and retention in clinical trials by moving trial activities to participants' homes and local surroundings. In this study, we conducted semi-structured interviews
Trials@Home Consortium
core
Annals of Internal Medicine, 2001 To comprehend the results of a randomized controlled trial (RCT), readers must understand its design, conduct, analysis and interpretation. That goal can only be achieved through complete transparency from authors.
D. Moher, K. Schulz, D. Altman
semanticscholar +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Targeting PI3K in cancer: mechanisms and advances in clinical trials
Molecular Cancer, 2019 Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important intracellular pathways, which can be considered as a master regulator for cancer. Enormous efforts have been dedicated to the development
Jing Yang +5 more
semanticscholar +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa +7 more
wiley +1 more source
Cardiovascular Risk Factor Control in Type 2 Diabetes Mellitus and New Trial Evidence
European Medical Journal, 2017 The micro and macrovascular complications of Type 2 diabetes mellitus are influenced by several well described cardiovascular risk factors such as hyperglycaemia, hypertension, hyperlipidaemia, and smoking alongside age, sex, and diabetes duration ...
Peter M. Nilsson
doaj