Results 121 to 130 of about 6,757,255 (356)

Meta-Analysis in Clinical Trials Revisited

Contemporary Clinical Trials, 2015
In this paper, we revisit a 1986 article we published in this Journal, Meta-Analysis in Clinical Trials, where we introduced a random-effect model to summarize the evidence about treatment efficacy from a number of related clinical trials. Because of its
R. Dersimonian, N. Laird
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

An overview of clinical trials in anal cancer 1999-2024

ESMO Gastrointestinal Oncology
Background: Anal cancer (AC) is an uncommon malignancy. Clinical trials are crucial for improving prevention and treatment, but conducting research is challenging in this condition.
D. Verschoor, E.S.L. Pedersen, A. Tardit, E. Segelov   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

From Editor-in-chief: On current issue, our policies, diversity and outstanding reviewers for year 2022, interesting trials, consensus documents, and long COVID

Heart Vessels and Transplantation, 2023
Gulmira Kudaiberdieva
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Communication about children's clinical trials as observed and experienced: qualitative study of parents and practitioners. [PDF]

, 2011
Recruiting children to clinical trials is perceived to be challenging. To identify ways to optimise recruitment and its conduct, we compared how parents and practitioners described their experiences of recruitment to clinical ...
Shilling, V, Smyth, RL, Bridget Young (128749), Helen Hickey (166297), Paula R. Williamson, Bridget Young, Helen Hickey, Emma Sowden (214406), Valerie Shilling (4460977), Paula R Williamson, Shilling Valerie, Beresford Michael W., Valerie Shilling, Young, B, Rosalind L Smyth, Michael W Beresford, Hickey Helen, Rosalind L Smyth (16234277), Michael W Beresford (9964186), Beresford, MW, Sowden, E, Williamson Paula R., Michael W. Beresford, Emma Sowden, Smyth Rosalind L., Young Bridget, Williamson, PR, Hickey, H, Rosalind L. Smyth, Sowden Emma, Paula R Williamson (11606900)   +30 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The Virtual Trial [PDF]

Frontiers in Neuroscience, 2017
Although brain network analysis in neurodegenerative disease is still a fairly young discipline, expectations are high. The robust theoretical basis, the straightforward detection and explanation of otherwise intangible complex system phenomena, and the correlations of network features with pathology and cognitive status are qualities that show the ...
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source