Results 31 to 40 of about 6,757,255 (356)

Contamination in trials of educational interventions [PDF]

, 2007
Objectives: To consider the effects of contamination on the magnitude and statistical significance (or precision) of the estimated effect of an educational intervention, to investigate the mechanisms of contamination, and to consider how contamination ...
Keogh-Brown, M.R., Bachmann, M.O., Ramsay, Craig R, Hewitt, C., Campbell, M.J., Torgerson, D.J., Miles, J.N.V., Howe, A., Shepstone, L., Elbourne, Diana R., Song, F, Harvey, I., Miles, S.   +12 more
core   +3 more sources

SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials

British medical journal, 2013
High quality protocols facilitate proper conduct, reporting, and external review of clinical trials. However, the completeness of trial protocols is often inadequate.
A. Chan, J. Tetzlaff, P. Gøtzsche, D. Altman, H. Mann, J. Berlin, K. Dickersin, A. Hrõbjartsson, K. Schulz, W. Parulekar, K. Krleza-Jeric, A. Laupacis, D. Moher   +12 more
semanticscholar   +1 more source

On the Use of Foreign Historical Examples (exempla) in Cicero`s Judicial and Political Speeches [PDF]

Античный мир и археология, 2019
The historical examples (exempla) are used very widely in quite different genres of Roman literature, including speeches. The focus of research is usually on Roman examples, whereas external historical examples are not yet sufficiently have found it ...
Chrustaljow, Wjatscheslaw Konstantinovich
doaj   +1 more source

Selective Reporting of Outcomes in Tinnitus Trials: Comparison of Trial Registries With Corresponding Publications

Frontiers in Neurology, 2021
Objectives: We aimed to study the prevalence of selective reporting of primary and secondary outcomes in tinnitus trials and to examine if selective reporting of outcome measures is influenced by the nature and direction of its results.Background ...
Isabeau van Beurden, Isabeau van Beurden, Megan J. van de Beek, Megan J. van de Beek, Jan A. A. van Heteren, Jan A. A. van Heteren, Adriana L. Smit, Adriana L. Smit, Inge Stegeman, Inge Stegeman   +9 more
doaj   +1 more source

Marketing and clinical trials : a case study [PDF]

, 2007
Background: Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well ...
Francis, D, Francis, David, McDonald, Alison Mary, Knight, R.C, McDonald, A.M, Garcia Jo, McDonald Alison M, Francis, David; id_orcid, McDonald, Alison M, Vikki A Entwistle, Campbell, Marion K, Rosemary C Knight, Snowdon Claire, Entwistle, V.A, Campbell, Marion K., Francis David, Grant Adrian M, Knight, Rosemary C, Haleema Shakur, Entwistle Vikki A, Roberts, Ian, Entwistle, Vikki A., Elbourne, D.R, Shakur, H, Entwistle, Vikki, Mcdonald, Alison M., Campbell, Marion Kay, Snowdon, Claire, Grant, Adrian M, Garcia, J, David Francis, Diana R Elbourne, Alison M McDonald, Elbourne, Diana R., Roberts Ian, Shakur, Haleema, Elbourne, Diana R, Grant, Adrian Maxwell, Campbell Marion K, Entwistle, Vikki A, Snowdon, C, Campbell, M.K, Shakur Haleema, Grant, Adrian M., Knight, Rosemary C., Garcia, Jo, Adrian M Grant, Ian Roberts, Claire Snowdon, Grant, A.M, Marion K Campbell, Knight Rosemary C, Jo Garcia, Elbourne Diana R, Roberts, I   +54 more
core   +4 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

What can we learn from clinical trials of anticonvulsant drugs in epilepsy?

, 2002
Any physician who intends to utilize the available antiepileptic drugs (AEDs) judiciously, cannot do so without being well versed on their pharmacological properties and the large body of evidence that is continuously accumulating on their relative ...
What Can We Learn From Clinical Trials Of Anticonvulsant Drugs In Epilepsy?, PERUCCA, EMILIO   +1 more
core   +1 more source

When and how should multiple imputation be used for handling missing data in randomised clinical trials – a practical guide with flowcharts

BMC Medical Research Methodology, 2017
BackgroundMissing data may seriously compromise inferences from randomised clinical trials, especially if missing data are not handled appropriately. The potential bias due to missing data depends on the mechanism causing the data to be missing, and the ...
J. Jakobsen, C. Gluud, J. Wetterslev, P. Winkel   +3 more
semanticscholar   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source