Results 41 to 50 of about 6,757,255 (356)

Health System Trials

, 2019
Pragmatic randomised trials aim to provide evidence to support decisions by stakeholders in healthcare systems (patients, clinicians, funders, policy makers).
Zwarenstein, Merrick,, Relton, Clare,, Fröbert, Ole,, Hemkens, Lars G.,, Verkooijen, Helena M.,   +4 more
core   +1 more source

SPIRIT 2025 statement: updated guideline for protocols of randomised trials

British medical journal
Importance The protocol of a randomised trial is the foundation for study planning, conduct, reporting, and external review. However, trial protocols vary in their completeness and often do not address key elements of design and conduct.
An-Wen Chan, Isabelle Boutron, Sally Hopewell, D. Moher, Kenneth F. Schulz, G. Collins, Ruth Tunn, Rakesh Aggarwal, Michael Berkwits, J. Berlin, Nita Bhandari, Nancy J. Butcher, Marion K. Campbell, Runcie C. W. Chidebe, Diana R. Elbourne, Andrew J Farmer, Dean A. Fergusson, Robert M. Golub, Steven N. Goodman, Tammy C. Hoffmann, J. Ioannidis, B. Kahan, Rachel L. Knowles, S. Lamb, Steff Lewis, E. Loder, Martin Offringa, Philippe Ravaud, Dawn P. Richards, Frank W. Rockhold, D. Schriger, N. Siegfried, Sophie Staniszewska, Rod S. Taylor, L. Thabane, D. Torgerson, Sunita Vohra, Ian R. White, A. Hróbjartsson   +38 more
semanticscholar   +1 more source

Design and data analysis 1 study design

Annals of Indian Academy of Neurology, 2012
This article is intended to give the reader guidance in evaluating different study designs used in medical research for better scientific quality, reliability and validity of their research.
Karthik Suresh, Geetha Suresh, Sanjeev V Thomas   +2 more
doaj   +1 more source

« Le dernier procès allemand pour crimes de guerre » : L'ancien officier SS Julius Viel et le procès de Ravensburg d’avril 2001 comme événement médiatique

Criminocorpus, 2023
In the second half of the twentieth century, the media played an important role in covering the trials of Nazi criminals. Regardless of the number of victims, the trials of Nazi criminals became media events that went beyond the usual scope of reporting ...
Vojtěch Kyncl
doaj   +1 more source

iRECIST: guidelines for response criteria for use in trials testing immunotherapeutics

The Lancet Oncology, 2017
Tumours respond differently to immunotherapies compared with chemotherapeutic drugs, raising questions about the assessment of changes in tumour burden—a mainstay of evaluation of cancer therapeutics that provides key information about objective response
L. Seymour, J. Bogaerts, A. Perrone, R. Ford, Lawrence H. Schwartz, S. Mandrekar, N. Lin, S. Litière, J. Dancey, Alice P. Chen, F. Hodi, P. Therasse, O. Hoekstra, L. Shankar, J. Wolchok, Marcus Ballinger, C. Caramella, E. D. de Vries   +17 more
semanticscholar   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Survey among experts on the future role of tau‐PET in clinical practice and trials

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
BACKGROUND Recent advancements in Alzheimer's disease (AD) biomarker research and clinical trials prompt reflection on the value and consequently appropriate use of tau positron emission tomography (tau‐PET) in the future.
Marie R. Vermeiren, Ismael L. Calandri, Wiesje M. van derFlier, Elsmarieke van deGiessen, Rik Ossenkoppele   +4 more
doaj   +1 more source

Roundtable: The Islandmagee Witches 1711 Creative and Digital Project [PDF]

Estudios Irlandeses, 2023
In March and September of 1711, in Carrickfergus, County Antrim, Ireland’s last witch trials took place. Eighteen-year-old educated gentlewoman Mary Dunbar accused eight Presbyterian women and one man from Islandmagee and the surrounding areas of using ...
VICTORIA MCCOLLUM, ANDREW SNEDDON, FRANK FERGUSON, STEPHEN BUTLER, ALICE MCCULLOUGH   +4 more
doaj  

Réseaux familiaux et institutionnels des religieuses : des alliés en justice ? Le cas des Visitandines de Rennes (xviie-xviiie siècles)

Criminocorpus, 2023
The unpublished correspondence exchanged between the Visitandines of Rennes, Bordeaux, Paris and Vannes (1641-1658, 1678-1683) is an exceptional source to shed light on nuns’judicial strategies.
Aude Loriaud
doaj   +1 more source

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.

New England Journal of Medicine, 2020
BACKGROUND Inclisiran inhibits hepatic synthesis of proprotein convertase subtilisin-kexin type 9. Previous studies suggest that inclisiran might provide sustained reductions in low-density lipoprotein (LDL) cholesterol levels with infrequent dosing ...
K. Ray, R. Wright, D. Kallend, W. Koenig, Lawrence A Leiter, F. Raal, Jenna A Bisch, Tara Richardson, M. Jaros, P. Wijngaard, J. Kastelein   +10 more
semanticscholar   +1 more source