Results 61 to 70 of about 6,757,255 (356)

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Global Efforts to Reduce Paediatric Cancer Care Disparities in Radiotherapy: A Decade Change

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We present an update on the status, needs and challenges faced by paediatric imaging and radiotherapy (RT) programmes globally after a previous survey conducted by the International Atomic Energy Agency (IAEA) 10 years prior. Methods We developed and distributed a 121‐question survey to radiation oncologists, medical physicists and ...
Raymond B. Mailhot Vega, Daniel J. Indelicato, Jeanette Parkes, Natia Esiashvili, Josué Hernández Benítez, Miriam Mikhail‐Lette, Olivera Cirajc Bjelac, Daniel Berger, Eva Ciurana, Yavuz Anacak, Lisbeth Cordero‐Mendez   +10 more
wiley   +1 more source

Strategies to improve recruitment to randomised controlled trials [PDF]

, 2010
Background Recruiting participants to trials can be extremely difficult. Identifying strategies that improve trial recruitment would benefit both trialists and health research.
Marie Pitkethly, Jones, R, Elizabeth Mitchell, Cook, Jonathan, Shaun Treweek, Treweek, S, Wilson, S, Kjeldstrøm, M, Kjeldstrom, Monica, Sue Wilson, Taskila, T, Johansen, Marit, Cook, J, Lockhart, Pauline, Taskila, Taina, Pauline Lockhart, Pitkethly, Marie, Taskil, T, Kjeldstrom, M, Treweek, Shaun, Sullivan, F, Cook, JAC, Jackson, Catherine Miriam, Monica Kjeldstrøm, Marit Johansen, Mitchell, Elizabeth, Taina K Taskila, Mitchell, E, Sullivan, Frank, Jackson, Catherine, Taskila, Taina K., Johansen, M, Catherine Jackson, Ritu Jones, Wilson, Sue, Mitchell, Lizabeth, Frank Sullivan, Jackson, C, Taina Taskila, Jones, Ritu, Pitkethly, M, Jonathan Cook   +41 more
core   +1 more source

Has mandatory prospective registration of all studies brought about a change? A 1-year audit of studies registered in the Clinical Trials Registry of India [CTRI] before and after April 1, 2018

Perspectives in Clinical Research, 2021
Introduction: The Clinical Trials Registry of India (CTRI) that initially permitted retrospective registration moved to mandatory prospective registration of studies with effect from April 1, 2018.
Nayana S Shetty, Rachana A Salvi, Urmila M Thatte, Nithya J Gogtay   +3 more
doaj   +1 more source

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.

British Journal of Cancer, 1977
Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of randomized clinical trials in which we wish to compare the ...
R. Peto, M. Pike, P. Armitage, N. Breslow, D. Cox, S. Howard, N. Mantel, K. McPherson, J. Peto, Peter Smith   +9 more
semanticscholar   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

A review of methodology for sample size calculations in cluster randomised trials. [PDF]

, 2011
PMCID: PMC3287737This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Rutterford, C, Clare Rutterford, Andrew Copas, Copas, A, Sandra Eldridge, Eldridge, S   +5 more
core   +1 more source

Why do so many trials of vitamin D supplementation fail?

Endocrine Connections, 2020
Our knowledge of vitamin D has come a long way since the 100 years it took for doctors to accept, between 1860 and 1890, that both sunlight and cod liver oil (a well-known folk remedy) cured and prevented rickets. Vitamins D2/D3 were discovered exactly a
Barbara J Boucher
doaj   +1 more source

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

A systematic review of cluster randomised trials in residential facilities for older people suggests how to improve quality. [PDF]

, 2013
BACKGROUND: Previous reviews of cluster randomised trials have been critical of the quality of the trials reviewed, but none has explored determinants of the quality of these trials in a specific field over an extended period of time.
Sheehan, B, Robert Froud, Sheehan, Bart, Froud, R, Bart Sheehan, Diaz-Ordaz, Karla, Eldridge, Sandra, Froud, Robert J., Diaz-Ordaz, K, Karla Diaz-Ordaz, Sandra Eldridge, Froud, Robert, Eldridge, S   +12 more
core   +2 more sources