Results 11 to 20 of about 5,142 (225)

In silico and in vivo screening of triamterene synthetic analogues as promising diuretics

Medičnì Perspektivi, 2022
The modification of lead-compound aimed to the increasing of activity, decrement of toxicity or improvement of selectivity is one of the most important methods used for elaboration of novel medications.
K.V. Sokolova, V.V. Stavytskyi, O.Yu. Voskoboinik, O.A. Podpletnya, S.I. Kovalenko   +4 more
doaj   +3 more sources

Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised controlled study [PDF]

BMJ Open
Introduction Hypertension constitutes the primary health burden of cardiovascular diseases, and the global control of blood pressure (BP) remains insufficient.
Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo   +12 more
doaj   +2 more sources

The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial [PDF]

Trials
Background Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite treatment with at least three or more antihypertensive agents.
Yuanyuan Yao, Xin Zhang, Runyu Ye, Shanshan Jia, Xiangyu Yang, Xiaoping Chen   +5 more
doaj   +2 more sources

Identification of Andrographolide as an Agonist of Bile Acid TGR5 Receptor in a Cell Line to Demonstrate the Reduction in Hyperglycemia in Type-1 Diabetic Rats [PDF]

Pharmaceuticals, 2023
Andrographolide (ADG) is contained in bitter plants, and its effects are widely thought to be associated with taste receptors. The current study used animal studies and cell lines to investigate the role of ADG in diabetic models.
Yingxiao Li, Kai-Chun Cheng, I-Min Liu, Juei-Tang Cheng   +3 more
doaj   +2 more sources

In-depth analysis of immune cell landscapes reveals differences between lung adenocarcinoma and lung squamous cell carcinoma [PDF]

Frontiers in Oncology
BackgroundLung cancer is the leading cause of cancer deaths globally, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being major subtypes.
Xinfeng Wang, Keao Zheng, Zhiying Hao
doaj   +2 more sources

Using computer modeling to find new LRRK2 inhibitors for parkinson’s disease [PDF]

Scientific Reports
Parkinson’s disease (PD) is a complex neurodegenerative disorder that affects multiple neurotransmitters, and its exact cause is still unknown. Developing new drugs for PD is a lengthy and expensive process, making it difficult to find new treatments ...
María C. García, Sebastián A. Cuesta, José R. Mora, Jose L. Paz, Yovani Marrero-Ponce, Frank Alexis, Edgar A. Márquez   +6 more
doaj   +2 more sources

Determination of triamterene in human plasma and urine after its cloud point extraction

Química Nova, 2014
A new analytical approach was developed involving cloud point extraction (CPE) and spectrofluorimetric determination of triamterene (TM) in biological fluids. A urine or plasma sample was prepared and adjusted to pH 7, then TM was quickly extracted using
Ahad Bavili Tabrizi, Sana Naini, Kosar Parnian, Samin Mohammadi, Fayeze Emami zad, Samira Pourtaghi Anvarian, Ali Abdollahi   +6 more
doaj   +2 more sources

Computational screening of FDA-approved drugs to identify potential TgDHFR, TgPRS, and TgCDPK1 proteins inhibitors against Toxoplasma gondii [PDF]

Scientific Reports, 2023
Toxoplasma gondii (T. gondii) is one of the most successful parasites in the world, because about a third of the world's population is seropositive for toxoplasmosis. Treatment regimens for toxoplasmosis have remained unchanged for the past 20 years, and
Zahra Gharibi, Behzad Shahbazi, Hamed Gouklani, Hoda Nassira, Zahra Rezaei, Khadijeh Ahmadi   +5 more
doaj   +2 more sources

Caveolae-dependent endocytosis mediates the cellular uptake of CdTe quantum dots in ovarian cancer cell lines [PDF]

Research in Pharmaceutical Sciences, 2022
Background and purpose: Quantum dots (QDs) are semiconductor nanocrystals that are widely used in biology due to their good optical properties. QDs, especially cadmium-based QDs, play an important role in the diagnosis and treatment of cancer due to ...
Zahra Asadian, Hakimeh Zare, Mahmoud Aghaei, Mojtaba Panjehpour   +3 more
doaj   +2 more sources

Effect of betahistine on pro-inflammatory cytokine expression in autoimmune inner ear disease and Meniere's disease patients. [PDF]

Laryngoscope Investig Otolaryngol
The aim of this study was to investigate the impact of betahistine on the salt induced cytokine expression profiles of AIED and MD patients. PBMCs were obtained from 24 patients with AIED or MD during an acute exacerbation of hearing loss and these PBMCs were cultured with 80 mM NaCl or a combination of 80 mM NaCl and betahistine.
Yellin I, Pathak S, Vambutas A.
europepmc   +2 more sources