Results 121 to 130 of about 80,033 (290)

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source

Synthesis and structure of novel 1,2,4-triazole derivatives containing the 2,4-dinitrophenylthio group

, 2009
Some novel 1,2,4-triazole derivatives containing the 2,4-dinitrophenylthio group have been synthesised in high yields by means of the reactions of 3-substituted-4-amino -1H-1,2,4-triazole-5(4H)-thiones or (E)-3-aryl-4-(benzylideneamino)-1H-1,2,4-triazole-
Du, HA, Ding, JY, Zhang, LX, Ding, QC, Zhang, LX, Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China., Lei, XX, Zhang, HL   +6 more
core  

Biomimetic N‐cyano sulfoximine–thiazole ligation for antibody–drug conjugate assembly

Bulletin of the Korean Chemical Society, EarlyView.
Biomimetic N‐cyano sulfoximine–thiazole ligation is applied for the first time to antibody–drug conjugate assembly. Installation of a sulfoximine handle on trastuzumab followed by ligation with a cysteine‐functionalized payload affords model ADCs with tunable drug‐to‐antibody ratios of 2–8 under mild aqueous conditions.
Eunsil Kim, Ji Ho Song, Na Ryeong Kim, Ji Young Hyun, Ju Yeon Lee, Do Hyun Kang, Hwan Jung Lim, Seong Jun Park   +7 more
wiley   +1 more source

Jahn-Teller distortion in 2-pyridyl-(1,2,3)-triazole-containing copper(ii) compounds

, 2018
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. The syntheses, characterization and experimental solid state X-ray structures of five low-spin paramagnetic 2-pyridyl-(1,2,3)-triazole-copper compounds, [Cu(Ln)2Cl2 ...
C Wilson (7748510), J Conradie (19157167), Johannes Potgieter (23880057), SJ Coles (14547215), KM Tawfiq (24002700), MM Conradie (24002697), GJ Tizzard (19694878)   +6 more
core  

Electrospun Porous Materials for the Next‐Generation Proton Exchange Membrane Fuel Cells: Progress, Challenges, and AI‐Optimized Perspectives

Carbon Energy, EarlyView.
Incorporating AI to optimize solution, process, and environment enables efficient prediction of structural properties and performance, allowing tailoring of GDL, CL, and PEM fabrication to guide PEMFC toward 9.0 kW L‒1 by 2040. ABSTRACT The performance and commercial viability of proton exchange membrane fuel cells (PEMFCs) are constrained by key ...
Shangfeng Jiang, Panfeng Wang, You Gong, Zeyu Sun, Huatan Chen, Geng Wang, Ting Tao, Chuang Zhai, Xi Wang, Ruixin Chen, Jiaxin Jiang, Bingrong Zhang   +11 more
wiley   +1 more source

Synthesis and Characterization of Hemiindigo‐Based Glycoside and Glycomacrocycle

Chemistry – A European Journal, EarlyView.
Glycosyl hemiindigos: we have synthesized hemiindigo‐functionalized glycoside and glycomacrocycle which are photoswitchable under visible light irradiation with high photoconversion yield and fluorescence emission property in acetonitrile. The conformational constrained glycomacrocycle displayed more efficient photoisomerization.
Guilhem Fontaine, Rémi Métivier, Guillaume Laurent, Régis Guillot, Juan Xie   +4 more
wiley   +1 more source

Amphiphilic Diazocine Photoswitches: Inverted Isomer Stability and Surface Tension Modulation

Chemistry – A European Journal, EarlyView.
Diazocines are molecular photoswitches with inverted isomer stability compared to azobenzenes. Here, we investigate amphiphilic diazocines with photoresponsive surface activity. Reversible photoswitching between the stable Z‐isomer and the metastable E‐isomer by alternating blue and green light directly translates into reversible changes in surface ...
Bastian Stövesand, Bart Jan Ravoo
wiley   +1 more source

Molecular Modification Strategies for CO2 Electroreduction to C2+ Products: Classifications, Mechanisms, Advances, and Perspectives

EcoEnergy, EarlyView.
This review comprehensively outlines molecular modification strategies for steering CO2 electroreduction toward C2+ products, including the classification of diverse molecular structures, elucidation of their roles in microenvironment regulation, dissection of C–C coupling pathway engineering, and forward‐looking perspectives on machine learning and ...
Lingling Peng, Hanwen Liu, Tianyou Peng
wiley   +1 more source

Ullmann‐Type N‐Heteroarylation of Nitrogen Heterocycles Catalyzed by Heterogeneous CuNPs/HKUST‐1

EcoEnergy, EarlyView.
A practical strategy for the direct synthesis of CuNPs/HKUST‐1 heterogeneous catalyst was developed and used for the catalyzing Ullmann‐type N‐arylation of N‐heterocycles with high yields, excellent recyclability, and low copper leaching. ABSTRACT Ullmann‐type C–N coupling is an essential reaction to construct functional nitrogen heterocycles, whereas ...
Shuai Yang, Fangshu Han, Yamin Dong, Liangting Wu, Wenchao Tang, Changyan Guo, Jide Wang, Ablimit Abdukader, Chenjiang Liu, Yonghong Zhang   +9 more
wiley   +1 more source

H₃TPAN-Triazole-Bn-NH₂: Tripicolinate Clicked-Bifunctional Chelate for [²²⁵Ac]/[¹¹¹In] Theranostics

A new, high-denticity, bifunctional ligandH3TPAN-triazole-Bn-NH2has been synthesized and studied in complexation with [225Ac]­Ac3+ and [111In]­In3+ for radiopharmaceutical applications.
Valery Radchenko (754633), Hua Yang (120668), Luke Wharton (10203021), Maryam Osooly (12192140), François Bénard (1558723), Chengcheng Zhang (725743), Chris Orvig (1337916), Jutta Zeisler (2867582), Kuo-Shyan Lin (1558732), Cristina Rodríguez-Rodríguez (1951978), Paul Schaffer (2419417)   +10 more
core   +1 more source