Results 101 to 110 of about 70,161 (298)
One-pot synthesis of novel 1,2,3-triazole-pyrimido[4,5-c]isoquinoline hybrids and evaluation of their antioxidant activity [PDF]
, 2018 A series of novel pyrimido[4,5-c]isoquinolines (3a–3h) and 1,2,3-triazole-coupled pyrimido[4,5-c]isoquinolines (4a–4h) were synthesized in good to excellent yields in the one-pot method.
Sirassu Narsimha (2831663) +2 more
core +1 more source
1-[(1-Benzyl-1H-1,2,3-triazol-4-yl)methyl]-1H-1,3-benzodiazole
IUCrData, 2017 The title molecule, C17H15N5, adopts a Z-shaped conformation, with the benzyl and benzodiazole substituents disposed on opposite sides of the plane of the triazole ring.
Azzeddine Sahbi +5 more
doaj +1 more source
New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2
Molecules, 2019 The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (ABT ...
Rania Hamdy +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.Die elektrochemische Energiespeicherung stößt bei extremer Miniaturisierung an fundamentale Grenzen, da Grenzflächen‐ und Raumladungseffekte dominieren. Hier stellen wir eine selektive Interphase mit ortsfesten Ladungen in einer Zwillingsrohr‐μ‐Swiss‐Roll‐Architektur vor.
Yaping Yan +12 more
wiley +1 more source
Triazole-based radiopeptidomimetics : novel neurotensin (8-13) analogues with increased metabolic stability [PDF]
, 2015 Neurotensin (NT) is a regulatory peptide with a nanomolar affinity towards NT receptors, which are overexpressed by different types clinically relevant tumours (e.g. Ewing’ sarcoma, breast, colon and exocrine pancreatic cancer).
Mascarin, Alba
core +1 more source
9-Ethyl-6-methyl-7H-1,2,4-triazolo[4,3-b][1,2,4]triazepin-8(9H)-one
IUCrData, 2016 In the title compound, C8H11N5O, the triazepine ring displays a boat conformation. Its mean plane is inclined to the triazole ring by 22.10 (9)°. In the crystal, molecules are linked by C—H...O hydrogen bonds to form chains parallel to the b-axis ...
Youness El Bakri +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner +5 more
wiley +1 more source
1,3,4-Thiadiazole and 1,2,4-triazole-3(4 H )-thione bearing salicylate moiety: synthesis and evaluation as anti- Candida albicans [PDF]
, 2017 Dramatically increased occurrence of both superficial and invasive fungal infections has been observed. Candida albicans appear to be the main etiological agent of invasive fungal infections. The anti-C.
Fares Kaed Alanazi (12847797) +2 more
core +1 more source
Angewandte Chemie, EarlyView.Eine divergente Aldehyd‐Funktionalisierungssequenz, ermöglicht durch ein anomeres Amid, erlaubt den Ein‐Topf‐Zugang zu unsymmetrischen Harnstoffen, Carbamaten, Thiocarbamaten, Thioestern und Amiden. Entscheidend für diese Transformation ist die Bildung von N‐Boc‐Hydroxamat‐Intermediaten, die als Plattformen für eine orthogonale Aktivierung über Lossen ...
Jasper L. Tyler +6 more
wiley +1 more source
Zaporožskij Medicinskij Žurnal, 2017 Over the past decade the number of publications, that contain different aspects of chemistry and use of triazoles and tetrazoles have been doubled and continues to grow. Puplications of recent years show that heterocycles with 1,2,3,4-teterazoles and 1,2,
Yu. S. Hulina, A. G. Kaplaushenko
doaj +1 more source