Results 91 to 100 of about 30,894 (155)

Theoretical Studies of the Structure, Tautomerism, and Vibrational Spectra of 3-Amino-5-nitro-1,2,4-triazole

, 2016
The structure, tautomerism, and vibrational spectra of the highly explosive 3-amino-5-nitro-1,2,4-triazole (ANTA) molecule were studied by ab initio molecular orbital calculations at the Hartree−Fock and second-order (MP2) and fourth-order (MP4) Möller ...
Carl M. Bennett (3053949), Dan C. Sorescu (1281933), Donald L. Thompson (2379148)   +2 more
core   +1 more source

Triazole-based STING inhibitors

Bioorganic & Medicinal Chemistry
Aberrant activation of the DNA sensing cGAS-STING pathway has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), systemic lupus erythematosus (SLE), and autoinflammatory disorders such as Aicardi-Goutières syndrome (AGS) and STING-associated vasculopathy with onset in infancy (SAVI). Consequently, considerable efforts have been
Singh, Anju, Barasa, Leonard, DeOrsey, Leo, O’Reilly, Maeve D., Choudhary, Shruti, Cahill, Sara E., Rossetti, Thomas, Green, Robert Madison, Humphries, Fiachra, Thompson, Paul R.   +9 more
openaire   +2 more sources

Polymorphism and Isostructurality of the Series of 3‑(4,5-Diaryl‑4H‑1,2,4-triazole-3-yl)propenoic Acid Derivatives

, 2017
Polymorphism of four biologically active 3-(4,5-diaryl-4H-1,2,4-triazole-3-yl)­propenoic acid derivatives has been investigated. Traditional solution-based solid-state forms screening revealed three anhydrous forms of 3-[4-phenyl-5-(2-pyridyl)-4H-1,2,4 ...
Anna E. Koziol (3053643), Katarzyna N. Jarzembska (1314447), Bożena Modzelewska-Banachiewicz (3862540), Liliana Mazur (1812037), Renata Paprocka (3862537)   +4 more
core   +1 more source

Recent developments on triazole nucleus in anticonvulsant compounds: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Epilepsy is one of the common diseases seriously threatening life and health of human. More than 50 million people are suffering from this condition and anticonvulsant agents are the main treatment.
Ming-Xia Song, Xian-Qing Deng
doaj   +1 more source

Au(III) and Pt(II) Complexes of a Novel and Versatile 1,4-Disubstituted 1,2,3-Triazole-Based Ligand Possessing Diverse Secondary and Tertiary Coordinating Groups

, 2018
A novel 1,4-disubstituted 1,2,3-triazole-based ligand, 2-(4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)­propane-1,3-diamine (ptpd), which possesses pyridyl and diamino secondary and tertiary coordinating groups was synthesized in excellent yield.
Brendan Twamley (1267278), Brendan Twamley, Zehao Zhou (5729411), Darren M. Griffith, Eolann Kitteringham, Zehao Zhou, Darren Griffith (7895342), Darren M. Griffith (5729414), Eolann Kitteringham (5729408)   +8 more
core   +1 more source

Synthesis of 1,2,3-triazoles and applications in the synthesis of BODIPY triazoles

, 2020
The 1,2,3-triazole ring is an important heterocycle which has found wide applications due to its interesting properties. Mainly due to the advent of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, 1,2,3-triazoles are nowadays unavoidable in the chemical literature. In the past decade, the development of transition metal-free synthetic
openaire   +2 more sources

Solid Phase Synthesis and TAR RNA-Binding Activity of Nucleopeptides Containing Nucleobases Linked to the Side Chains via 1,4-Linked-1,2,3-triazole

Biomedicines
Nucleopeptides (NPs) represent synthetic polymers created by attaching nucleobases to the side chains of amino acid residues within peptides. These compounds amalgamate the characteristics of peptides and nucleic acids, showcasing a unique ability to ...
Piotr Mucha, Małgorzata Pieszko, Irena Bylińska, Wiesław Wiczk, Jarosław Ruczyński, Katarzyna Prochera, Piotr Rekowski   +6 more
doaj   +1 more source

One-pot synthesis of novel 1,2,3-triazole-pyrimido[4,5-c]isoquinoline hybrids and evaluation of their antioxidant activity

, 2018
A series of novel pyrimido[4,5-c]isoquinolines (3a–3h) and 1,2,3-triazole-coupled pyrimido[4,5-c]isoquinolines (4a–4h) were synthesized in good to excellent yields in the one-pot method.
Sirassu Narsimha (2831663), Vasudeva Reddy Nagavelli (5048300), Kumara Swamy Battula (2831660)   +2 more
core   +1 more source

Jahn-Teller distortion in 2-pyridyl-(1,2,3)-triazole-containing copper(ii) compounds

, 2018
© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. The syntheses, characterization and experimental solid state X-ray structures of five low-spin paramagnetic 2-pyridyl-(1,2,3)-triazole-copper compounds, [Cu(Ln)2Cl2 ...
C Wilson (7748510), J Conradie (19157167), Johannes Potgieter (23880057), SJ Coles (14547215), KM Tawfiq (24002700), MM Conradie (24002697), GJ Tizzard (19694878)   +6 more
core  

1,3,4-Thiadiazole and 1,2,4-triazole-3(4 H )-thione bearing salicylate moiety: synthesis and evaluation as anti- Candida albicans

, 2017
Dramatically increased occurrence of both superficial and invasive fungal infections has been observed. Candida albicans appear to be the main etiological agent of invasive fungal infections. The anti-C.
Fares Kaed Alanazi (12847797), Awwad Abdoh Radwan (12847794), Mohammed Hamed Al-Agamy (12847800)   +2 more
core   +1 more source