Results 81 to 90 of about 30,894 (155)

2H‑1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design

, 2018
Macrocyclic inhibitors of rhodesain (RD), a parasitic cysteine protease and drug target for the treatment of human African trypanosomiasis, have shown low metabolic stability at the macrocyclic ether bridge.
Saint-Auret, Sarah, Wolfgang Haap (1856404), Tanja Schirmeister, Haap, Wolfgang, Bernd Kuhn, Maude Giroud, Bernd Kuhn (260084), Christoph Kuratli (2184006), Rainer E. Martin (1934101), Rainer E. Martin, Marcel Kaiser (41510), Schuler, Franz, Schirmeister, Tanja, Diederich, François, Kaiser, Marcel, Tanja Schirmeister (634370), François Diederich, Marcel Kaiser, Maude Giroud (2017114), Kuratli, Christoph, Christoph Kuratli, Franz Schuler (1416097), Franz Schuler, Sarah Saint-Auret (5071748), Brun, Reto, Sarah Saint-Auret, Giroud, Maude, Reto Brun, Reto Brun (41511), François Diederich (1336185), Martin, Rainer E., Kuhn, Bernd, Wolfgang Haap   +32 more
core   +1 more source

New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2

Molecules, 2019
The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (ABT ...
Rania Hamdy, Samia A. Elseginy, Noha I. Ziedan, Arwyn T. Jones, Andrew D. Westwell   +4 more
doaj   +1 more source

9-Ethyl-6-methyl-7H-1,2,4-triazolo[4,3-b][1,2,4]triazepin-8(9H)-one

IUCrData, 2016
In the title compound, C8H11N5O, the triazepine ring displays a boat conformation. Its mean plane is inclined to the triazole ring by 22.10 (9)°. In the crystal, molecules are linked by C—H...O hydrogen bonds to form chains parallel to the b-axis ...
Youness El Bakri, Abdallah Harmaoui, El Mokhtar Essassi, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

From Mono to Tris-1,2,3-triazole-Stabilized Gold Nanoparticles and Their Compared Catalytic Efficiency in 4‑Nitrophenol Reduction

, 2016
Mono-, bis-, and tris-1,2,3-triazole ligands are used for the stabilization of gold nanoparticles (AuNPs), and the catalytic activities of these AuNPs in 4-nitrophenol reduction by NaBH4 in water are compared as well as with polyethylene glycol 2000 (PEG)
Sergio Moya (1353486), María Echeverría Igartua (2829920), Jaime Ruiz (1353474), Didier Astruc (1353480), Changlong Wang (1915549), Lionel Salmon (1353471), Qian Li (114642), Roberto Ciganda (1536853)   +7 more
core   +1 more source

Thermodynamic Analysis and Pyrolysis Mechanism of 4,4′-Azobis-1,2,4-triazole

, 2023
The nonisothermal thermal decomposition kinetics of 4,4′-azobis-1,2,4-triazole (ATRZ) at different heating rates (5, 10, 15, and 20 °C·min–1) were investigated by thermogravimetry (TG) and differential scanning calorimetry (DSC) studies.
Linan Zhang, Kaiyi Qin, Benduan Cheng, Mingmin Zhang, Qiuhan Lin, Qiuhan Lin (4517425), Kaiyi Qin (6413708), Linan Zhang (1418215), Mimi Zhu (5997824), Mingmin Zhang (5218220), Benduan Cheng (14613269), Mimi Zhu   +11 more
core   +1 more source

Synthesis and physical-chemical properties of 6-(5-(1Н-tetrazole-1-ylmethyl)-4-R-1,2,4-triazole-3-ylthio)pyridin-3-amines and 6-((5-(1Н-tetrazole-1-yl)methil-4-R-1,2,4-triazole-3-ylthio)pyridin-3-yl)-(alk,ar,heter)ylmethanimines

Zaporožskij Medicinskij Žurnal, 2017
Over the past decade the number of publications, that contain different aspects of chemistry and use of triazoles and tetrazoles have been doubled and continues to grow. Puplications of recent years show that heterocycles with 1,2,3,4-teterazoles and 1,2,
Yu. S. Hulina, A. G. Kaplaushenko
doaj   +1 more source

Syntheses, Antibacterial and Antifungal Activities of Substituted-Thiazolo-1,3,4-Thiadiazoles, 1,3,4-Oxadiazoles and 1,2,4-Thiazoles [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 1998
Starting from readily available 2-substituted-4-methylthiazole-5-carboxylic acid hydrazide (1), The title compounds were prepared. The reaction of compound 1 (R=CH3) with formic acid yielded 1-(formyl)-2-(2,4-dimethylthiazole-5-carboxyl) hydrazine (2 ...
Abbas Shafiee, Amir Reza Jalilian, Mojtaba Tabatabaiee Yazdi   +2 more
doaj  

Triazole Substituted Phthalocyanines and Their Electrochemical Properties

Hittite Journal of Science and Engineering, 2018
New cobalt II , zinc II , tin II and metal free phthaloyanines having peripherally triazole and Schiff’s base groups on were synthesized and their electrochemical properties were studied. In the first step of the synthetic procedure, triazole moiety,
Rıza Bayrak
doaj   +1 more source

Cu-Mediated Expeditious Annulation of Alkyl 3‑Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N²‑Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis

, 2020
Alkyl N-aryl 1,2,3-triazole-carboxylates are important molecules or intermediates in medicinal chemistry, but the synthesis of N2-aryl counterparts remains elusive.
Jun-An Ma (1393726), Chi Wai Cheung (614393), Hao-Qiang Cao (8398338), Hao-Nan Liu (8398335)   +3 more
core   +1 more source

Agar: a natural and environmentally-friendly support composed of copper oxide nanoparticles for the green synthesis of 1,2,3–triazoles

Green Chemistry Letters and Reviews, 2019
A novel, green and cost-effective heterogeneous nanocatalyst was synthesized by supporting copper (I) oxide nanoparticles on magnetic agar (Cu2O/Agar@Fe3O4).
Ali Maleki, Morteza Panahzadeh, Reza Eivazzadeh-keihan   +2 more
doaj   +1 more source