Results 71 to 80 of about 30,894 (155)

Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors

Frontiers in Chemistry
IntroductionThis work outlines the design, synthesis, and biological evaluation of a new series of benzimidazole/1,2,3-triazole hybrids as apoptotic antiproliferative agents that inhibit the EGFR pathway.MethodsThe research assesses the antiproliferative
Alshimaa A. Y. Ahmed, Anber F. Mohammed, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif   +4 more
doaj   +1 more source

Crystal structure, computational study and Hirshfeld surface analysis of ethyl (2S,3R)-3-(3-amino-1H-1,2,4-triazol-1-yl)-2-hydroxy-3-phenylpropanoate

Acta Crystallographica Section E: Crystallographic Communications, 2019
In the title molecule, C13H16N4O3, the mean planes of the phenyl and triazole rings are nearly perpendicular to one another as a result of the intramolecular C—H...O and C—H...π(ring) interactions.
Abdelkader Ben Ali, Youness El Bakri, Chin-Hung Lai, Jihad Sebhaoui, Lhoussaine El Ghayati, El Mokhtar Essassi, Joel T. Mague   +6 more
doaj   +1 more source

Triazole Evolution of Candida parapsilosis Results in Cross-Resistance to Other Antifungal Drugs, Influences Stress Responses, and Alters Virulence in an Antifungal Drug-Dependent Manner

mSphere, 2020
The number of invasive infections caused by Candida species is increasing worldwide. The incidence of candidiasis cases caused by non-albicans Candida species, such as Candida parapsilosis, is also increasing, and non-albicans Candida species are ...
Csaba Papp, Flóra Bohner, Katica Kocsis, Mónika Varga, András Szekeres, László Bodai, Jesse R. Willis, Toni Gabaldón, Renáta Tóth, Joshua D. Nosanchuk, Csaba Vágvölgyi, Attila Gácser   +11 more
doaj   +1 more source

Crystal structure of 2-(4-fluoro-3-methylphenyl)-5-{[(naphthalen-1-yl)oxy]methyl}-1,3,4-oxadiazole

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C20H15FN2O2, adopts an almost planar conformation. The oxadiazole ring makes dihedral angles of 13.90 (1) and 7.93 (1)° with the naphthalene ring system and benzene ring, respectively, while the naphthalene ring system and benzene ...
Muniyappan Govindhan, Kathavarayan Subramanian, Vijayan Viswanathan, Devadasan Velmurugan   +3 more
doaj   +1 more source

Pulmonary Verruconis Infection in an Immunocompetent Patient: A Case Report and Literature Review

Journal of Fungi
Verruconis species are thermophilic, darkly pigmented fungi commonly found in hot environments. Despite their environmental ubiquity, fewer than fifty human infections have been reported, with V. gallopava responsible for most cases.
Lulu Xu, Lili Tao
doaj   +1 more source

5-(5-Aryl-1,3,4-oxadiazole-2-carbonyl)furan-3-carboxylate and New Cyclic <em>C</em>-Glycoside Analogues from Carbohydrate Precursors with MAO-B, Antimicrobial and Antifungal Activities

Molecules, 2012
Cyclization of acyclic <em>C</em>-glycoside derivatives <strong>1a,b</strong> to <strong>2a,b</strong> as the major isomers, and <strong>4a,b</strong> as the minor isomers were carried out.
Nagwa Said Abd El-Dayem, Galila Ahmed Yacout, Seham Yassen Hassan, Mohamed Mohamed El-Sadek   +3 more
doaj   +1 more source

New 1,2,3-Triazole-genipin Analogues and Their Anti-Alzheimer’s Activity

A novel series of 1,2,3-triazole-genipin analogues were designed, synthesized, and evaluated for neuroprotective activity, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) inhibitory activity.
Jiraporn Tocharus (4672513), Apichart Suksamrarn (482768), Suwichada Jaipea (13008125), Patamawadee Silalai (13008122), Rungnapha Saeeng (2686342), Anan Athipornchai (6160775)   +5 more
core   +1 more source

Regioselective synthesis, antitumor and antioxidant activities of some 1,2,4-triazole derivatives based on 4-phenyl-5-(quinolin-8-yloxy)methyl-4H-1,2,4-triazole-3-thiol

, 2017
Regioselective synthesis of some triazole derivatives 4–18 was achieved from the versatile, readily accessible 4-phenyl-5-(quinolin-8-yloxy)methyl-4H-1,2,4-triazole-3-thiol/thione 3.
M. S. Amine (3610862), M. S. Behalo (3610865), I. M. Fouda (3610868)   +2 more
core   +1 more source

Multisite-Sequential Cyclization To Construct 1,2,4-Triazole-Based N‑Fused Heterocyclics

, 2023
A feasible protocol that uses atomic groups (KSCN, KSeCN, and NH2CN), o-bromobenzoyl hydrazides, and formyls as reaction factors to synthesize N-fused 1,2,4-triazole with benzothiazides, benzoselenazinones, and quinazolinones was proposed.
Yao Li (154923), Jun Zhang (48506), Guojin Sun (14127869), Lang Liu (1693300), Shengyong Zhang (1816435), Jianli Li (335935), Zesi Wang (7325357), Changting Wen (14689251), Zhe Zhang (81603), Mengyao She (1555243), Ping Liu (156158)   +10 more
core   +1 more source

1-[(1-Benzyl-1H-1,2,3-triazol-4-yl)methyl]-1H-1,3-benzodiazole

IUCrData, 2017
The title molecule, C17H15N5, adopts a Z-shaped conformation, with the benzyl and benzodiazole substituents disposed on opposite sides of the plane of the triazole ring.
Azzeddine Sahbi, Ismail Fichtali, Joel T. Mague, Abdeslem Ben-Tama, El Mestafa El Hadrami, Youssef Kandri Rodi   +5 more
doaj   +1 more source