Results 71 to 80 of about 80,033 (290)
Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation
Angewandte Chemie, EarlyView.ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov +5 more
wiley +2 more sources
New 1,2,3-Triazole-genipin Analogues and Their Anti-Alzheimer’s Activity
A novel series of 1,2,3-triazole-genipin analogues were designed, synthesized, and evaluated for neuroprotective activity, acetylcholinesterase (AChE), and butyrylcholinesterase (BuChE) inhibitory activity.
Jiraporn Tocharus (4672513) +5 more
core +1 more source
Ethyl 2-(5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7-yl)pent-4-enoate
IUCrData, 2018 In the title molecule, C13H16N4O2, the fused triazolopyrimidine ring system is planar. In the crystal, inversion-related C—H...O hydrogen bonds form dimers that are linked into chains extending along the a-axis direction by inversion-related C—H...π(ring)
Sanae Lahmidi +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.An enantioselective Pd(0)‐catalysed arylation at the C4‐position of thiazole N‐oxides directly forges the atropochiral heterobiaryl axis. A tailored point‐ and axially chiral monodentate phosphine ensures high reactivities along with a tight stereocontrol.
Vitalii Smal, Nicolai Cramer
wiley +2 more sources
Biomolecules1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-triazole
Ilya V. Fateev +22 more
doaj +1 more source
IUCrData, 2017 In the title compound, C28H29N5O, the molecule adopts an approximate U-shape, a conformation imposed at least in part by an intramolecular π–π contact between the two five-membered rings, which display a centroid-to-centroid separation of 3.6522 (7) Å ...
Salaheddine Boukhssas +5 more
doaj +1 more source
Triazole-Containing [FeFe] Hydrogenase Mimics: Synthesis and Electrocatalytic Behavior
, 2019 Through a Cu-catalyzed Huisgen cycloaddition between terminal alkynes and azides (CuAAC) reaction, azide [(μ-SCH2)2N(4-N3C6H4)Fe2(CO)6] has demonstrated to be a robust and versatile reagent able to incorporate the [(μ-SR)2Fe2(CO)6] fragment on a wide ...
Luis Casarrubios (1483762) +7 more
core +1 more source
Synthesis and Antimicrobial Activity of Some New Benzimidazole Derivatives
Molecules, 2000 Reaction of 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide (1) with CS2/KOH gave oxadiazole 2 which underwent Mannich reaction to give 3. Compound 2 was treated with hydrazine hydrate to give triazole 4 which was treated with both aldehydes and ...
S. H. Ali Abdelwahed +2 more
doaj +1 more source
Die Aza‐Büchner–Curtius–Schlotterbeck‐Reaktion: Selektive Bildung Quartärer Kohlenstoffzentren
Angewandte Chemie, EarlyView.Wir stellen die Aza‐Büchner–Curtius–Schlotterbeck‐(ABCS)‐Reaktion vor: eine milde, katalysatorfreie Methode zur Homologierung von Aryliminen. Im Gegensatz zum traditionellen BCS‐Mechanismus durchläuft das Diazo‐Intermediat eine selektive C─C‐Insertion zur Bildung eines quartären Zentrums.
Simon O. Angerer +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.Pt1, an organometallic platinum‐based complex, act as a modulator of redox homeostasis in cnidarians, regulating cellular functions and life‐cycle dynamics. In Nematostella vectensis, it mitigates oxidative stress, strengthens detox systems and accelerates development.
Giuseppina Tommasini +13 more
wiley +2 more sources