Nature MethodsAfter having been largely neglected for more than a century, the tiny marine animal Trichoplax adhaerens is enjoying a revival and is now poised to become a mainstream model organism for the study of epithelial evolution, diversification and specialization.
Leria, Marvin +3 more
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Coordinated cellular behavior regulated by epinephrine neurotransmitters in the nerveless placozoa [PDF]
Nature CommunicationsUnderstanding how cells communicated before the evolution of nervous systems in early metazoans is key to unraveling the origins of multicellular life.
Minjun Jin +7 more
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The cobalamin processing enzyme of Trichoplax adhaerens. [PDF]
J Biol ChemCobalamin (Cbl) is an essential cofactor for methionine synthase and methylmalonyl-CoA mutase, but it must first undergo chemical processing for utilization in animals. In humans, this processing comprises β-axial ligand cleavage and Cbl reduction and is performed by the enzyme MMACHC (HsCblC).
Krams C +8 more
europepmc +5 more sources
Apicortin, a Putative Apicomplexan-Specific Protein, Is Present in Deep-Branching Opisthokonts [PDF]
BiologyApicortin, a tubulin/microtubule-binding protein, was first described in 2009 as a protein characteristic of apicomplexans; it was found to be present in all Apicomplexa genomes already sequenced.
Ferenc Orosz
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Correction: Upregulation of DNA repair genes and cell extrusion underpin the remarkable radiation resistance of Trichoplax adhaerens. [PDF]
PLoS Biology[This corrects the article DOI: 10.1371/journal.pbio.3001471.].
Angelo Fortunato +3 more
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PLoS Biology, 2021 Trichoplax adhaerens is the simplest multicellular animal with tissue differentiation and somatic cell turnover. Like all other multicellular organisms, it should be vulnerable to cancer, yet there have been no reports of cancer in T.
Angelo Fortunato +3 more
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Long-Term Culturing of Placozoans (Trichoplax and Hoilungia)
The phylum Placozoa remains one of the least explored among early-branching metazoan lineages. For over 130 years, this phylum had been represented by the single species Trichoplax adhaerens-an animal with the simplest known body plan (three cell layers without any organs) but complex behaviors.
Daria Y, Romanova +5 more
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Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms [PDF]
Nature CommunicationsNucleocytoplasmic protein O-GlcNAcylation is a dynamic modification catalysed by O-GlcNAc transferase (OGT) and reversed by O-GlcNAc hydrolase (OGA), whose activities are regulated through largely unknown O-GlcNAc-dependent feedback mechanisms.
Sara Basse Hansen +10 more
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Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses
Journal of Experimental Biology, 2017 ABSTRACT Trichoplax adhaerens is a flat, millimeter-sized marine animal that adheres to surfaces and grazes on algae. Trichoplax displays a repertoire of different feeding behaviors despite the apparent absence of a true nervous system with electrical or chemical synapses. It glides along surfaces to find food, propelled by beating cilia
Adriano Senatore +2 more
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Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor [PDF]
Communications BiologyEpsilon ionotropic glutamate receptors (iGluRs) are a recently defined clade of neurotransmitter receptors that are found in all major metazoan lineages that are distinct from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, delta ...
Anhadvir Singh +9 more
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