Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms [PDF]
Nature CommunicationsNucleocytoplasmic protein O-GlcNAcylation is a dynamic modification catalysed by O-GlcNAc transferase (OGT) and reversed by O-GlcNAc hydrolase (OGA), whose activities are regulated through largely unknown O-GlcNAc-dependent feedback mechanisms.
Sara Basse Hansen +10 more
doaj +3 more sources
Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor [PDF]
Communications BiologyEpsilon ionotropic glutamate receptors (iGluRs) are a recently defined clade of neurotransmitter receptors that are found in all major metazoan lineages that are distinct from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, delta ...
Anhadvir Singh +9 more
doaj +2 more sources
Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior. [PDF]
PLoS ONEPlacozoa are millimeter-sized, flat, irregularly shaped ciliated animals that crawl on surfaces in warm oceans feeding on biofilms, which they digest externally. They stand out from other animals due to their simple body plans.
Tatiana D Mayorova +5 more
doaj +2 more sources
Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle [PDF]
Life Science AllianceApicortin shapes the Plasmodium cytoskeleton at the apical end without impacting transmission. Apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii possess unique tubulin-based structures, including subpellicular microtubules and apical ...
Mohammad Zeeshan +7 more
doaj +2 more sources
The ancestral architecture of the immune system in simplest animals [PDF]
Frontiers in ImmunologyDaria Y. Romanova +2 more
doaj +2 more sources
Why Homoscleromorph Sponges Have Ciliated Epithelia: Evidence for an Ancestral Role in Mucociliary Driven Particle Flux. [PDF]
J Exp Zool B Mol Dev EvolEpithelia are typically ciliated, except in sponges. Of all Porifera only Homoscleromorphs have motile cilia on their epithelia. Our data highlight the presence of cilia and mucociliary particle transport as a common feature of metazoa and a secondary loss in other sponge lineages.
Price VL +9 more
europepmc +2 more sources
The Trichoplax genome and the nature of placozoans [PDF]
Nature, 2008 As arguably the simplest free-living animals, placozoans may represent a primitive metazoan form, yet their biology is poorly understood. Here we report the sequencing and analysis of the approximately 98 million base pair nuclear genome of the placozoan Trichoplax adhaerens.
Srivastava, Mansi +20 more
openaire +5 more sources
Differentiation of Crystal Cells, Gravity-Sensing Cells in the Placozoan Trichoplax adhaerens
Journal of Marine Science and Engineering, 2021 Trichoplax adhaerens are simple animals with no nervous system, muscles or body axis. Nevertheless, Trichoplax demonstrate complex behaviors, including responses to the direction of the gravity vector.
Tatiana D. Mayorova
doaj +1 more source
The early ANTP gene repertoire: insights from the placozoan genome. [PDF]
PLoS ONE, 2008 The evolution of ANTP genes in the Metazoa has been the subject of conflicting hypotheses derived from full or partial gene sequences and genomic organization in higher animals.
Bernd Schierwater +5 more
doaj +1 more source
Bioeffects of Prunus spinosa L. fruit ethanol extract on reproduction and phenotypic plasticity of Trichoplax adhaerens Schulze, 1883 (Placozoa) [PDF]
PeerJ, 2019 The aim of this work was to test and analyse the bioeffects of Prunus spinosa L. (Rosacaee) fruit ethanol extract on Trichoplax adhaerens Schulze, 1883 (Placozoa) laboratory cultures which—for the first time—were employed as in vivo biological model to ...
Maria Cristina Albertini +12 more
doaj +2 more sources