Journal of Biological Chemistry, 2020 The dominant role of CaV2 voltage-gated calcium channels for driving neurotransmitter release is broadly conserved. Given the overlapping functional properties of CaV2 and CaV1 channels, and less so CaV3 channels, it is unclear why there have not been ...
Adriano Senatore +2 more
exaly +3 more sources
Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses
Journal of Experimental Biology, 2017 Trichoplax adhaerens is a flat, millimeter-sized marine animal that adheres to surfaces and grazes on algae. Trichoplax displays a repertoire of different feeding behaviors despite the apparent absence of a true nervous system with electrical or chemical
A. Senatore, T. Reese, Carolyn L. Smith
semanticscholar +2 more sources
Two intracellular and cell type-specific bacterial symbionts in the placozoan Trichoplax H2 [PDF]
Nature Microbiology, 2019 Placozoa is an enigmatic phylum of simple, microscopic, marine metazoans1,2. Although intracellular bacteria have been found in all members of this phylum, almost nothing is known about their identity, location and interactions with their host3–6.
Harald R. Gruber-Vodicka +7 more
semanticscholar +2 more sources
Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor [PDF]
Communications BiologyEpsilon ionotropic glutamate receptors (iGluRs) are a recently defined clade of neurotransmitter receptors that are found in all major metazoan lineages that are distinct from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, delta ...
Anhadvir Singh +9 more
doaj +2 more sources
Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior. [PDF]
PLoS ONEPlacozoa are millimeter-sized, flat, irregularly shaped ciliated animals that crawl on surfaces in warm oceans feeding on biofilms, which they digest externally. They stand out from other animals due to their simple body plans.
Tatiana D Mayorova +5 more
doaj +2 more sources
The ancestral architecture of the immune system in simplest animals [PDF]
Frontiers in ImmunologyDaria Y. Romanova +2 more
doaj +2 more sources
Nature MethodsInternational audienceAfter having been largely neglected for more than a century, the tiny marine animal Trichoplax adhaerens is enjoying a revival and is now poised to become a mainstream model organism for the study of epithelial evolution ...
Marvin Leria +3 more
semanticscholar +2 more sources
Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms
Nature CommunicationsNucleocytoplasmic protein O-GlcNAcylation is a dynamic modification catalysed by O-GlcNAc transferase (OGT) and reversed by O-GlcNAc hydrolase (OGA), whose activities are regulated through largely unknown O-GlcNAc-dependent feedback mechanisms.
Sara Basse Hansen +10 more
doaj +2 more sources
Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle [PDF]
Life Science AllianceApicortin shapes the Plasmodium cytoskeleton at the apical end without impacting transmission. Apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii possess unique tubulin-based structures, including subpellicular microtubules and apical ...
Mohammad Zeeshan +7 more
doaj +2 more sources
Fast calcium-dependent reorientation of motile cilia basal bodies in the simple metazoan, Trichoplax
bioRxivCiliary-based animal locomotion relies on the spatially coordinated beating of motile cilia to displace the body in liquid environments or across solid surfaces.
Marvin Leria +6 more
semanticscholar +2 more sources