Results 21 to 30 of about 1,730 (164)

The cobalamin processing enzyme of Trichoplax adhaerens. [PDF]

J Biol Chem
Cobalamin (Cbl) is an essential cofactor for methionine synthase and methylmalonyl-CoA mutase, but it must first undergo chemical processing for utilization in animals. In humans, this processing comprises β-axial ligand cleavage and Cbl reduction and is performed by the enzyme MMACHC (HsCblC).
Krams C, Esser AJ, Klenzendorf M, Klotz K, Spiekerkoetter U, Jacobsen DW, Smith CA, Maggiolo AO, Hannibal L.   +8 more
europepmc   +4 more sources

Animal Evolution: Trichoplax, Trees, and Taxonomic Turmoil [PDF]

Current Biology, 2008
The genome sequence of Trichoplax adhaerens, the founding member of the enigmatic animal phylum Placozoa, has revealed that a surprising level of genetic complexity underlies its extremely simple body plan, indicating either that placozoans are secondarily simple or that there is an undiscovered morphologically complex life stage.
Miller, David J., Ball, Eldon E.
openaire   +3 more sources

Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 11, Page 1510-1524, November 2023., 2023
Abstract The hypoxia‐inducible factor (HIF) prolyl‐hydroxylases (human PHD1‐3) catalyze prolyl hydroxylation in oxygen‐dependent degradation (ODD) domains of HIFα isoforms, modifications that signal for HIFα proteasomal degradation in an oxygen‐dependent manner. PHD inhibitors are used for treatment of anemia in kidney disease. Increased erythropoietin
William D. Figg Jr., Giorgia Fiorini, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A. McDonough, Christopher J. Schofield   +6 more
wiley   +1 more source

Defining bone fide effectors of RAS GTPases

BioEssays, Volume 45, Issue 9, September 2023., 2023
RAS GTPases transmit extracellular signals to multiple intracellular signalling pathways through direct interaction with effector proteins. These proteins typically employ RAS‐binding RBD domains to complex with activated GTPases, but the specificity of these interactions remains poorly explored and there remain few data describing the mechanistic ...
Matthew J. Smith
wiley   +1 more source

Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif‐mediated interactions

Protein Science, Volume 32, Issue 7, July 2023., 2023
Abstract The interaction between the transcription factor p53 and the ubiquitin ligase MDM2 results in the degradation of p53 and is well‐studied in cancer biology and drug development. Available sequence data suggest that both p53 and MDM2‐family proteins are present across the animal kingdom.
Filip Mihalič, Emma Åberg, Pouria Farkhondehkish, Niels Theys, Eva Andersson, Per Jemth   +5 more
wiley   +1 more source

Physiological insight into the conserved properties of Caenorhabditis elegans acid‐sensing degenerin/epithelial sodium channels

The Journal of Physiology, Volume 601, Issue 9, Page 1625-1653, 1 May 2023., 2023
Abstract figure legend Polar view of a phylogram of representative members of the DEG/ENaC superfamily, coloured according to phylum (Annelida, yellow; Arthropoda, light green; Chordata, dark green; Cnidaria, blue; Mollusca, dark purple; Nematoda, magenta; Placozoa, red). Construction of the phylogram is described in Fig. 1.
Eva Kaulich, Patrick T. N. McCubbin, William R. Schafer, Denise S. Walker   +3 more
wiley   +1 more source

Placozoan fiber cells: mediators of innate immunity and participants in wound healing

Scientific Reports, 2021
Placozoa is a phylum of non-bilaterian marine animals. These small, flat organisms adhere to the substrate via their densely ciliated ventral epithelium, which mediates mucociliary locomotion and nutrient uptake.
Tatiana D. Mayorova, Katherine Hammar, Jae H. Jung, Maria A. Aronova, Guofeng Zhang, Christine A. Winters, Thomas S. Reese, Carolyn L. Smith   +7 more
doaj   +1 more source

Upregulation of DNA repair genes and cell extrusion underpin the remarkable radiation resistance of Trichoplax adhaerens.

PLoS Biology, 2021
Trichoplax adhaerens is the simplest multicellular animal with tissue differentiation and somatic cell turnover. Like all other multicellular organisms, it should be vulnerable to cancer, yet there have been no reports of cancer in T.
Angelo Fortunato, Alexis Fleming, Athena Aktipis, Carlo C Maley   +3 more
doaj   +1 more source

The diverse functions of the DEG/ENaC family: linking genetic and physiological insights

The Journal of Physiology, Volume 601, Issue 9, Page 1521-1542, 1 May 2023., 2023
Abstract figure legend Schematic illustration of the diverse modulators and stimuli that influence DEG/ENaC function (blue arrows) and the diverse range of functions in which they have been implicated (green arrows), in an array of animals, exemplified by those depicted. Created with Biorender.com.
Eva Kaulich, Laura J. Grundy, William R. Schafer, Denise S. Walker   +3 more
wiley   +1 more source

Ndst1, a heparan sulfate modification enzyme, regulates neuroectodermal patterning by enhancing Wnt signaling in Xenopus

Development, Growth &Differentiation, Volume 65, Issue 3, Page 153-160, April 2023., 2023
ndst1 is expressed in anterior neural plate and the trigeminal region in Xenopus neurula. It enhances Wnt signaling in a region‐specific manner by accumulating Wnt ligand. This makes a clear boundary of Wnt signaling, and governs neuroectodermal patterning.
Takayoshi Yamamoto, Yuta Kambayashi, Kohei Tsukano, Tatsuo Michiue   +3 more
wiley   +1 more source