Results 21 to 30 of about 2,098 (195)
Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior. [PDF]
PLoS ONEPlacozoa are millimeter-sized, flat, irregularly shaped ciliated animals that crawl on surfaces in warm oceans feeding on biofilms, which they digest externally. They stand out from other animals due to their simple body plans.
Tatiana D Mayorova +5 more
doaj +2 more sources
Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle [PDF]
Life Science AllianceApicortin shapes the Plasmodium cytoskeleton at the apical end without impacting transmission. Apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii possess unique tubulin-based structures, including subpellicular microtubules and apical ...
Mohammad Zeeshan +7 more
doaj +2 more sources
Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens [PDF]
Scientific Reports, 2016 AbstractThe identification of genes encoding a p53 family member and an Mdm2 ortholog in the ancient placozoan Trichoplax adhaerens advocates for the evolutionary conservation of a pivotal stress-response pathway observed in all higher eukaryotes. Here, we recapitulate several key functionalities ascribed to this known interacting protein pair by ...
Siau, J.W +7 more
openaire +5 more sources
The ventral epithelium of Trichoplax adhaerens deploys in distinct patterns cells that secrete digestive enzymes, mucus or diverse neuropeptides [PDF]
Biology Open, 2019 The disk-shaped millimeter-sized marine animal, Trichoplax adhaerens, is notable because of its small number of cell types and primitive mode of feeding.
Tatiana D. Mayorova +4 more
doaj +2 more sources
The ancestral architecture of the immune system in simplest animals [PDF]
Frontiers in ImmunologyDaria Y. Romanova +2 more
doaj +2 more sources
Why Homoscleromorph Sponges Have Ciliated Epithelia: Evidence for an Ancestral Role in Mucociliary Driven Particle Flux. [PDF]
J Exp Zool B Mol Dev EvolEpithelia are typically ciliated, except in sponges. Of all Porifera only Homoscleromorphs have motile cilia on their epithelia. Our data highlight the presence of cilia and mucociliary particle transport as a common feature of metazoa and a secondary loss in other sponge lineages.
Price VL +9 more
europepmc +2 more sources
The early ANTP gene repertoire: insights from the placozoan genome. [PDF]
PLoS ONE, 2008 The evolution of ANTP genes in the Metazoa has been the subject of conflicting hypotheses derived from full or partial gene sequences and genomic organization in higher animals.
Bernd Schierwater +5 more
doaj +1 more source
Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 11, Page 1510-1524, November 2023., 2023 Abstract The hypoxia‐inducible factor (HIF) prolyl‐hydroxylases (human PHD1‐3) catalyze prolyl hydroxylation in oxygen‐dependent degradation (ODD) domains of HIFα isoforms, modifications that signal for HIFα proteasomal degradation in an oxygen‐dependent manner. PHD inhibitors are used for treatment of anemia in kidney disease. Increased erythropoietin
William D. Figg Jr. +6 more
wiley +1 more source
Defining bone fide effectors of RAS GTPases
BioEssays, Volume 45, Issue 9, September 2023., 2023 RAS GTPases transmit extracellular signals to multiple intracellular signalling pathways through direct interaction with effector proteins. These proteins typically employ RAS‐binding RBD domains to complex with activated GTPases, but the specificity of these interactions remains poorly explored and there remain few data describing the mechanistic ...
Matthew J. Smith
wiley +1 more source
Protein Science, Volume 32, Issue 7, July 2023., 2023 Abstract The interaction between the transcription factor p53 and the ubiquitin ligase MDM2 results in the degradation of p53 and is well‐studied in cancer biology and drug development. Available sequence data suggest that both p53 and MDM2‐family proteins are present across the animal kingdom.
Filip Mihalič +5 more
wiley +1 more source