Results 31 to 40 of about 2,412 (183)

Why Homoscleromorph Sponges Have Ciliated Epithelia: Evidence for an Ancestral Role in Mucociliary Driven Particle Flux. [PDF]

J Exp Zool B Mol Dev Evol
Epithelia are typically ciliated, except in sponges. Of all Porifera only Homoscleromorphs have motile cilia on their epithelia. Our data highlight the presence of cilia and mucociliary particle transport as a common feature of metazoa and a secondary loss in other sponge lineages.
Price VL, Nanayakkara A, Pasini A, Bazellières E, Vernale A, Rocher C, Borchiellini C, Le Bivic A, Renard E, Leys SP.   +9 more
europepmc   +2 more sources

The early ANTP gene repertoire: insights from the placozoan genome. [PDF]

PLoS ONE, 2008
The evolution of ANTP genes in the Metazoa has been the subject of conflicting hypotheses derived from full or partial gene sequences and genomic organization in higher animals.
Bernd Schierwater, Kai Kamm, Mansi Srivastava, Daniel Rokhsar, Rafael D Rosengarten, Stephen L Dellaporta   +5 more
doaj   +1 more source

Growth produces coordination trade-offs in Trichoplax adhaerens, an animal lacking a central nervous system

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Coordination between cells is fundamental for multicellular life. The first multicellular animals were capable of growing to indeterminate sizes but lacked nervous systems that could facilitate coordination. We investigate how size variation
Mircea Davidescu, P. Romanczuk, Thomas Gregor, I. Couzin   +3 more
semanticscholar   +1 more source

Spatial Models of Piezoproteins and Networks of Protein-Protein Interactions in Trichoplax Animals (Placozoa)

Молекулярная биология, 2023
The marine free-living organism Trichoplax (phylum Placozoa) resembles the unicellular amoeba in shape and type of movement. Trichoplax diverged from the main evolutionary tree in the Neoproterozoic Era and is one of the simplest models of a ...
A. V. Kuznetsov, I. Y. Grishin, D. Vtyurina   +2 more
semanticscholar   +1 more source

Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 11, Page 1510-1524, November 2023., 2023
Abstract The hypoxia‐inducible factor (HIF) prolyl‐hydroxylases (human PHD1‐3) catalyze prolyl hydroxylation in oxygen‐dependent degradation (ODD) domains of HIFα isoforms, modifications that signal for HIFα proteasomal degradation in an oxygen‐dependent manner. PHD inhibitors are used for treatment of anemia in kidney disease. Increased erythropoietin
William D. Figg Jr., Giorgia Fiorini, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A. McDonough, Christopher J. Schofield   +6 more
wiley   +1 more source

CHARACTERISTICS OF THE CATIONIC TRPA1-CHANNALS FAMILY IN TRICHOPLAX SP. H2 (PLACOZOA)

Russian Journal of Biological Physics and Chemisrty, 2022
Mechanoreceptors can transform external mechanical forces into electrochemical signals that induce cell membrane depolarization and initiate waves propagating along the cell surface. The TRPN1/NompC mechanotransduction channel is known to contain ankyrin
M. Fadeeva, E. Sergeeva, K. Rybakova, A. Kuznetsov   +3 more
semanticscholar   +1 more source

Defining bone fide effectors of RAS GTPases

BioEssays, Volume 45, Issue 9, September 2023., 2023
RAS GTPases transmit extracellular signals to multiple intracellular signalling pathways through direct interaction with effector proteins. These proteins typically employ RAS‐binding RBD domains to complex with activated GTPases, but the specificity of these interactions remains poorly explored and there remain few data describing the mechanistic ...
Matthew J. Smith
wiley   +1 more source

Selective behavioral response of Trichoplax (Placozoa) to RGB-light stimuli

Hygiene and Sanitation, 2022
Introduction. The marine animal Trichoplax (Placozoa), which has the animalcular organization among invertebrates, but with outstanding social behaviour and specific movement of the body and its cells, is a model animal for studying various biophysical ...
V. Kaptsov, V. N. Deynego, Daniil V. Kozyritsky   +2 more
semanticscholar   +1 more source

Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif‐mediated interactions

Protein Science, Volume 32, Issue 7, July 2023., 2023
Abstract The interaction between the transcription factor p53 and the ubiquitin ligase MDM2 results in the degradation of p53 and is well‐studied in cancer biology and drug development. Available sequence data suggest that both p53 and MDM2‐family proteins are present across the animal kingdom.
Filip Mihalič, Emma Åberg, Pouria Farkhondehkish, Niels Theys, Eva Andersson, Per Jemth   +5 more
wiley   +1 more source

Placozoan fiber cells: mediators of innate immunity and participants in wound healing

Scientific Reports, 2021
Placozoa is a phylum of non-bilaterian marine animals. These small, flat organisms adhere to the substrate via their densely ciliated ventral epithelium, which mediates mucociliary locomotion and nutrient uptake.
Tatiana D. Mayorova, Katherine Hammar, Jae H. Jung, Maria A. Aronova, Guofeng Zhang, Christine A. Winters, Thomas S. Reese, Carolyn L. Smith   +7 more
doaj   +1 more source