Results 21 to 30 of about 1,839 (188)

The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System [PDF]

Journal of Biological Chemistry, 2015
Protein O-GlcNAcylation is a reversible post-translational signaling modification of nucleocytoplasmic proteins that is essential for embryonic development in bilateria. In a search for a reductionist model to study O-GlcNAc signaling, we discovered the presence of functional O-GlcNAc transferase (OGT), O-GlcNAcase (OGA), and nucleocytoplasmic protein ...
Nithya Selvan, Daniel Mariappa, Henk W. P. van den Toorn, Albert J. R. Heck, Andrew T. Ferenbach, Daan M. F. van Aalten   +5 more
openalex   +7 more sources

The placozoan Trichoplax

Nature Methods
After having been largely neglected for more than a century, the tiny marine animal Trichoplax adhaerens is enjoying a revival and is now poised to become a mainstream model organism for the study of epithelial evolution, diversification and specialization.
Marvin Léria, Magali Requin, André Le Bivic, Andrea Pasini   +3 more
openalex   +4 more sources

Differentiation of Crystal Cells, Gravity-Sensing Cells in the Placozoan Trichoplax adhaerens

Journal of Marine Science and Engineering, 2021
Trichoplax adhaerens are simple animals with no nervous system, muscles or body axis. Nevertheless, Trichoplax demonstrate complex behaviors, including responses to the direction of the gravity vector.
Tatiana D. Mayorova
doaj   +1 more source

Trichoplax adhaerens F. E. Schulze (Placozoa): The Formation of Swarmers [PDF]

Zeitschrift für Naturforschung C, 1988
Abstract Flageilated swarmers representing an alternative mode of asexual reproduction are budded off as hollow spheres at the dorsal surface. They are covered by cells of the dorsal epithelium and the interior cavity is lined by ventral epithelium. Fiber cells are in the interspace.
Martin Thiemann, August Ruthmann
openalex   +2 more sources

The cobalamin processing enzyme of Trichoplax adhaerens. [PDF]

J Biol Chem
Cobalamin (Cbl) is an essential cofactor for methionine synthase and methylmalonyl-CoA mutase, but it must first undergo chemical processing for utilization in animals. In humans, this processing comprises β-axial ligand cleavage and Cbl reduction and is performed by the enzyme MMACHC (HsCblC).
Krams C, Esser AJ, Klenzendorf M, Klotz K, Spiekerkoetter U, Jacobsen DW, Smith CA, Maggiolo AO, Hannibal L.   +8 more
europepmc   +4 more sources

The early ANTP gene repertoire: insights from the placozoan genome. [PDF]

PLoS ONE, 2008
The evolution of ANTP genes in the Metazoa has been the subject of conflicting hypotheses derived from full or partial gene sequences and genomic organization in higher animals.
Bernd Schierwater, Kai Kamm, Mansi Srivastava, Daniel Rokhsar, Rafael D Rosengarten, Stephen L Dellaporta   +5 more
doaj   +1 more source

Bioeffects of Prunus spinosa L. fruit ethanol extract on reproduction and phenotypic plasticity of Trichoplax adhaerens Schulze, 1883 (Placozoa) [PDF]

PeerJ, 2019
The aim of this work was to test and analyse the bioeffects of Prunus spinosa L. (Rosacaee) fruit ethanol extract on Trichoplax adhaerens Schulze, 1883 (Placozoa) laboratory cultures which—for the first time—were employed as in vivo biological model to ...
Maria Cristina Albertini, Daniele Fraternale, Federica Semprucci, Silvio Cecchini, Mariastella Colomba, Marco B.L. Rocchi, Davide Sisti, Barbara Di Giacomo, Michele Mari, Luigia Sabatini, Lucia Cesaroni, Maria Balsamo, Loretta Guidi   +12 more
doaj   +2 more sources

Structural basis for binding of the renal carcinoma target hypoxia‐inducible factor 2α to prolyl hydroxylase domain 2

Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 11, Page 1510-1524, November 2023., 2023
Abstract The hypoxia‐inducible factor (HIF) prolyl‐hydroxylases (human PHD1‐3) catalyze prolyl hydroxylation in oxygen‐dependent degradation (ODD) domains of HIFα isoforms, modifications that signal for HIFα proteasomal degradation in an oxygen‐dependent manner. PHD inhibitors are used for treatment of anemia in kidney disease. Increased erythropoietin
William D. Figg Jr., Giorgia Fiorini, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A. McDonough, Christopher J. Schofield   +6 more
wiley   +1 more source

Animal Evolution: Trichoplax, Trees, and Taxonomic Turmoil [PDF]

Current Biology, 2008
The genome sequence of Trichoplax adhaerens, the founding member of the enigmatic animal phylum Placozoa, has revealed that a surprising level of genetic complexity underlies its extremely simple body plan, indicating either that placozoans are secondarily simple or that there is an undiscovered morphologically complex life stage.
Miller, David J., Ball, Eldon E.
openaire   +3 more sources

Defining bone fide effectors of RAS GTPases

BioEssays, Volume 45, Issue 9, September 2023., 2023
RAS GTPases transmit extracellular signals to multiple intracellular signalling pathways through direct interaction with effector proteins. These proteins typically employ RAS‐binding RBD domains to complex with activated GTPases, but the specificity of these interactions remains poorly explored and there remain few data describing the mechanistic ...
Matthew J. Smith
wiley   +1 more source