Results 31 to 40 of about 131 (115)
BioEssays, Volume 43, Issue 7, July 2021., 2021 Development and maintenance of organs requires context‐specific regulation of stem cell activities. We hypothesize that these are dependent upon reciprocal interactions between the cell‐cycle machinery and regulators of stem cell differentiation. To support this, we discuss the mechanistic links between these processes, as well as their parallel ...
Jonas Muhr, Daniel W. Hagey
wiley +1 more source
Genome-wide analysis of transposable elements and tandem repeats in the compact placozoan genome
Biology Direct, 2010 The placozoan Trichoplax adhaerens has a compact genome with many primitive eumetazoan characteristics. In order to gain a better understanding of its genome architecture, we conducted a detailed analysis of repeat content in this genome.
Meyer Eli +3 more
doaj +1 more source
Evolution of the perlecan/HSPG2 gene and its activation in regenerating Nematostella vectensis. [PDF]
PLoS ONE, 2015 The heparan sulfate proteoglycan 2 (HSPG2)/perlecan gene is ancient and conserved in all triploblastic species. Its presence maintains critical cell boundaries in tissue and its large (up to ~900 kDa) modular structure has prompted speculation about the ...
Curtis R Warren +5 more
doaj +1 more source
Studying Placozoa WBR in the Simplest Metazoan Animal, Trichoplax adhaerens
, 2022 AbstractPlacozoans are a promising model system to study fundamental regeneration processes in a morphologically and genetically very simple animal. We here provide a brief introduction to the enigmatic Placozoa and summarize the state of the art of animal handling and experimental manipulation possibilities.
Hans-Jürgen Osigus +7 more
openaire +2 more sources
Deep RNA sequencing reveals the smallest known mitochondrial micro exon in animals: The placozoan cox1 single base pair exon. [PDF]
PLoS ONE, 2017 The phylum Placozoa holds a key position for our understanding of the evolution of mitochondrial genomes in Metazoa. Placozoans possess large mitochondrial genomes which harbor several remarkable characteristics such as a fragmented cox1 gene and trans ...
Hans-Jürgen Osigus +2 more
doaj +1 more source
Frontiers in Endocrinology, 2022 Bilateria have bilateral symmetry and are subdivided into Deuterostomia (animals like vertebrates) and Protostomia (animals like insects and mollusks).
Frank Hauser +3 more
doaj +1 more source
Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens [PDF]
Scientific Reports, 2016 AbstractThe identification of genes encoding a p53 family member and an Mdm2 ortholog in the ancient placozoan Trichoplax adhaerens advocates for the evolutionary conservation of a pivotal stress-response pathway observed in all higher eukaryotes. Here, we recapitulate several key functionalities ascribed to this known interacting protein pair by ...
Siau, J.W +7 more
openaire +3 more sources
Comparative genomics of large mitochondria in placozoans.
PLoS Genetics, 2007 The first sequenced mitochondrial genome of a placozoan, Trichoplax adhaerens, challenged the conventional wisdom that a compact mitochondrial genome is a common feature among all animals.
Ana Y Signorovitch +2 more
doaj +1 more source
Comparative genomics of neuroglobin reveals its early origins. [PDF]
PLoS ONE, 2012 Neuroglobin (Ngb) is a hexacoordinated globin expressed mainly in the central and peripheral nervous system of vertebrates. Although several hypotheses have been put forward regarding the role of neuroglobin, its definite function remains uncertain.
Jasmin Dröge +3 more
doaj +1 more source
Concatenated analysis sheds light on early metazoan evolution and fuels a modern "urmetazoon" hypothesis. [PDF]
PLoS Biology, 2009 For more than a century, the origin of metazoan animals has been debated. One aspect of this debate has been centered on what the hypothetical "urmetazoon" bauplan might have been.
Bernd Schierwater +7 more
doaj +1 more source