Results 51 to 60 of about 131 (115)
Beyond the Secretory Pathway: New Insights Into Protein Release
Traffic, Volume 26, Issue 10-12, October/December 2025.While proteins bearing N‐terminal signal or leader sequences are secreted via the ER‐Golgi‐plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequence can be secreted via poorly defined mechanisms termed Unconventional Protein Secretion (UcPS).
Ruey‐Hwa Chen +34 more
wiley +1 more source
Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis. [PDF]
PLoS Genetics, 2013 The evolution of metazoans from their choanoflagellate-like unicellular ancestor coincided with the acquisition of novel biological functions to support a multicellular lifestyle, and eventually, the unique cellular and physiological demands of ...
Melissa Y Frédéric +11 more
doaj +1 more source
Invertebrate Bile Acid‐Sensitive Ion Channels and Their Emergence in Bilateria
The FASEB Journal, Volume 39, Issue 8, 30 April 2025.This graphical abstract presents the evolutionary distribution and functional characteristics of bile acid‐sensing ion channels (BASICs) across bilaterians. A phylogenetic tree illustrates the presence of BASICs in diverse groups, extending beyond previously established mammalian findings.
Josep Martí‐Solans +4 more
wiley +1 more source
Apicortin, a Putative Apicomplexan-Specific Protein, Is Present in Deep-Branching Opisthokonts
BiologyApicortin, a tubulin/microtubule-binding protein, was first described in 2009 as a protein characteristic of apicomplexans; it was found to be present in all Apicomplexa genomes already sequenced.
Ferenc Orosz
doaj +1 more source
Deep proteome profiling of Trichoplax adhaerens reveals remarkable features at the origin of metazoan multicellularity [PDF]
Nature Communications, 2013 Genome sequencing of arguably the simplest known animal, Trichoplax adhaerens, uncovered a rich array of transcription factor and signalling pathway genes. Although the existence of such genes allows speculation about the presence of complex regulatory events, it does not reveal the level of actual protein expression and functionalization through ...
Jeffrey H. Ringrose +7 more
openaire +2 more sources
Domain‐Shuffling in the Evolution of Cyclostomes and Gnathostomes
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 344, Issue 2, Page 59-79, March 2025.We addressed the potential roles of domain‐shuffling origin genes (DSO‐Gs) in the evolution of early vertebrates. Through comparative genome analysis of 22 metazoans, including four cyclostomes, we identified DSO‐Gs before and after the divergence of cyclostomes and gnathostomes, and suggest domain shuffling as a key mechanism in vertebrate early ...
Hirofumi Kariyayama +3 more
wiley +1 more source
The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens [PDF]
The EMBO Reports, 2010 The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhaerens: HIF targets in T.
Loenarz, C +6 more
openaire +5 more sources
Evolution of the Cdk4/6–Cdkn2 system in invertebrates
Genes to Cells, Volume 29, Issue 11, Page 1037-1051, November 2024.Hypothesis on the evolution of the Cdkn2 locus. (a) Loss of Cdkn2 occurred multiple times. (b) Evolution of microsynteny at the Cdkn2 locus. Cdkn2e is a hypothetical transient gene. Abstract The cell cycle is driven by cyclin‐dependent kinases (Cdks). The decision whether the cell cycle proceeds is made during G1 phase, when Cdk4/6 functions.
Shiori Yuki +5 more
wiley +1 more source
FEBS Letters, Volume 598, Issue 15, Page 1811-1838, August 2024.This Review presents the main advances in the study of PTP1B since it was first isolated, and recent contextual information related to this protein. Furthermore, we provide an overview of the role of PTP1B in diabetes and obesity, and the challenges of developing selective, effective, potent, bioavailable, and cell‐permeable compounds that can inhibit ...
Andrea Coronell‐Tovar +7 more
wiley +1 more source
Molecular mechanisms of perilipin protein function in lipid droplet metabolism
FEBS Letters, Volume 598, Issue 10, Page 1170-1198, May 2024.Lipid droplets (LDs) are important for the storage of energy and lipid components. The perilipin family in mammals includes five proteins (PLIN1 to PLIN5), all of which are abundant on the surface of LDs in different tissues and play a role in LD stability and degradation by lipases.
Elena Griseti +7 more
wiley +1 more source