Results 51 to 60 of about 1,374 (169)

In vitro anti-Leishmania activity of triclabendazole and its synergic effect with amphotericin B

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionLeishmaniasis is a neglected tropical disease, with approximately 1 million new cases and 30,000 deaths reported every year worldwide. Given the lack of adequate medication for treating leishmaniasis, drug repositioning is essential to save ...
Beatriz Santana Borges, Gislayne de Paula Bueno, Fernanda Tomiotto-Pellissier, Fernanda Tomiotto-Pellissier, Fabiano Borges Figueiredo, Lia Carolina Soares Medeiros   +5 more
doaj   +1 more source

Current Insight on Cost‐Effective Management Strategies for Fasciola hepatica Disease in Cattle

Journal of Applied Mathematics, Volume 2026, Issue 1, 2026.
Fasciola hepatica is a parasitic flatworm that causes fascioliasis, a significant disease in livestock leading to substantial economic losses in agriculture. This paper develops and analyzes a mathematical model that incorporates optimal control strategies to manage the transmission of F. hepatica.
Dagnaw Tantie Yihunie, Dawit Melese Gebru, Haileyesus Tessema Alemneh, Yibekal Walle Dilie, Mohammad Rezwan Habib   +4 more
wiley   +1 more source

Pilot Evaluation of Two Fasciola hepatica Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics

Molecules, 2020
Fasciola hepatica, the causative agent of fasciolosis, is a global threat to public health, animal welfare, agricultural productivity, and food security.
Clare F. Collett, Russell M. Morphew, David Timson, Helen C. Phillips, Peter M. Brophy   +4 more
doaj   +1 more source

Solid dispersion complex triclabendazole preparations with succinic acid and their fasciolocidal activity

Российский паразитологический журнал, 2023
The purpose of the research is to test the efficacy of triclafascid and two solid dispersion complex preparations based on the triclabendazole substance against fasciolosis in cattle and sheep. Materials and methods.
M. B. Musaev, M. S. Khalikov, A. Z. Dzhamalova, M. M. Ilyin, S. S. Khalikov   +4 more
doaj   +1 more source

Evaluation of Imatinib and Its Combination With Albendazole Against Echinococcus granulosus Protoscoleces and Microcysts In Vitro

Journal of Parasitology Research, Volume 2026, Issue 1, 2026.
Background Currently, benzimidazoles are the main drugs used for the treatment of hydatidosis. However, the available medications do not demonstrate the expected therapeutic efficacy. As a tyrosine kinase inhibitor, imatinib may interfere with parasite signaling pathways and exert antiparasitic effects.
Zahra Hanifeh, Ali Haniloo, Negin Torabi, Mehdi Farhadi, Satabdi Datta Choudhury   +4 more
wiley   +1 more source

Piperonyl butoxide enhances triclabendazole action against triclabendazole-resistant Fasciola hepatica

Parasitology, 2010
SUMMARYA study has been carried out to determine whether the action of triclabendazole (TCBZ) against the liver fluke, Fasciola hepatica is altered by inhibition of the cytochrome P450 (CYP 450)-mediated drug metabolism pathway. The Oberon TCBZ-resistant and Cullompton TCBZ-susceptible fluke isolates were used for these experiments, the basic design of
C, Devine, G P, Brennan, C E, Lanusse, L I, Alvarez, A, Trudgett, E, Hoey, I, Fairweather   +6 more
openaire   +3 more sources

Prevalence of Bovine Fasciolosis and Its Associated Risk Factors in and Around Hawassa Town, Ethiopia

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Fasciolosis is an economically important disease of domestic livestock, particularly in cattle. A cross‐sectional study was conducted to estimate the prevalence and assess associated risk factors of bovine fasciolosis in and around Hawassa Town from December 2023 to May 2024.
Teshager Dubie, Miesa Gobena, Ashenafi Syoum, Fanuel Bizuayehu Yihunie, Lipi Buch   +4 more
wiley   +1 more source

Prevalence of Bovine Fasciolosis in Ethiopia, 2010–2024: A Systematic Review and Meta‐Analysis

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Bovine fasciolosis is a neglected zoonotic and economically crucial parasitic disease of cattle caused by Fasciola spp. However, estimates of the overall prevalence of bovine fasciolosis in Ethiopia are lacking. Therefore, this study aimed to determine the overall prevalence of bovine fasciolosis nationally by a systematic review and meta‐analysis of ...
Mitiku Wamile, Yismaw Alemie, Megersa Gemechu, Tuge Temesgen, Wakuma Mitiku Bune, Mahmoud Elhaig   +5 more
wiley   +1 more source

Autochthonous Human Fascioliasis, Belgium

Emerging Infectious Diseases, 2020
We report 2 cases of human fascioliasis (HF) in Belgium, likely caused by consumption of vegetables from a garden that was flooded by pasture runoff. Because autochthonous HF is rare and the route of transmission was unusual, HF was not diagnosed until 6
Sandrine Milas, Camelia Rossi, Ivan Philippart, Pierre Dorny, Emmanuel Bottieau   +4 more
doaj   +1 more source

Packaging, Labeling, and Physical Characteristics and Sales Volume Assessment of Veterinary Antimicrobials in a Resource‐Limited Setting: Evidence From Hawassa Town, Ethiopia

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Background Antibiotics and anthelmintics are widely used in veterinary medicine to prevent, control, and treat infectious diseases. However, in resource‐limited settings, the widespread circulation of poor‐quality medicines and their inappropriate use have become major obstacles to delivering effective animal healthcare.
Lelisa Ache Yohannes, Yesuneh Tefera Mekasha, Melese Tilahun, Mikael Abreham, Gemmechu Hasen, Sileshi Belew, Lipi Buch   +6 more
wiley   +1 more source