Results 71 to 80 of about 1,374 (169)

Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano.

PLoS Neglected Tropical Diseases, 2012
BackgroundThe Bolivian northern Altiplano is characterized by a high prevalence of Fasciola hepatica infection. In order to assess the feasibility, safety and efficacy of large-scale administration of triclabendazole as an appropriate public health ...
Fidel Villegas, René Angles, René Barrientos, Gary Barrios, María Adela Valero, Kamal Hamed, Heiner Grueninger, Steven K Ault, Antonio Montresor, Dirk Engels, Santiago Mas-Coma, Albis Francesco Gabrielli   +11 more
doaj   +1 more source

Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years

Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1743-1753, June 2025.
Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

A Five-Year Single-Center Experience with Fasciola hepatica Infection

Mediterranean Journal of Infection, Microbes and Antimicrobials
Introduction: Fasciola hepatica infection (fascioliasis) is an uncommon zoonotic parasitic disease in humans that primarily involves the hepatobiliary system.
Ömür Gündağ, Yasemin Kırık, Zekiye Çatak   +2 more
doaj   +1 more source

A comparison study on the anti-leech effects of onion (Allium cepa L) and ginger (Zingiber officinale) with levamisole and triclabendazole [PDF]

Journal of HerbMed Pharmacology, 2013
Introduction: Leech may indwell in mucosa of the pharynx, tonsil, esophagus, nose, nasopharyngeal and rarely in larynx of hosts, however, the effective drugs against this parasite is scarce.
Bahmani Mahmoud, Vakili-Saatloo Naiema, Gholami-Ahangaran Majid, Karamati Seyed Ahmad, Banihabib Ebrahimkhalil, Hajigholizadeh Ghader, Borjian Sayfollah   +6 more
doaj  

EFFICACY OF SUPRAMOLECULAR COMPLEX BASED ON ALBENDAZOLE AND TRICLABENDAZOLE AGAINST FASCIOLOSIS AND GASTRO-INTESTINAL NEMATODOSIS OF SHEEP

Российский паразитологический журнал, 2019
The purpose of the research is to define efficacy and to carry out titration of therapy dose of supramolecular complex of albendazole extra and triclabendazole in case of fasciolosis and gastro-intestinal nematodosis of sheep.Materials and methods ...
E. V. Lagereva, V. E. Abramov, M. B. Musaev, S. S. Khalikov   +3 more
doaj   +1 more source

Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica

Parasitology Research, 2011
A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism. The cytochrome P450 (CYP 450) enzyme pathway was inhibited using ketoconazole (KTZ) to see whether a TCBZ-resistant isolate could be made more sensitive to TCBZ action. The Oberon TCBZ-resistant
Devine, C., Brennan, G.P., Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, I.   +6 more
openaire   +4 more sources

Alteration in Haematological and Liver Function Indices during Human Infection with Fasciola spp. Post Treatment with Triclabendazole

پزشکی بالینی ابن سینا, 2006
Introduction & Objective: Fascioliasis is a zoonotic parasitic disease, caused by the liver fluke, Fasciola spp.. Human is occasional host when ingesting the metacercaria by eating contaminated aquatic vegetable.
Mohammad Ismaeil Edalatzadeh, Abdolhosein Dalimi Asl, Fatemeh Ghafarifar, Babak Sayaad   +3 more
doaj  

Subchronic toxicity of the supramolecular complex of triclabendazole

Российский паразитологический журнал, 2019
Objective of research: Preclinical assessment of subchronic toxicity of the supramolecular complex of Triclabendazole applied on laboratory animals. Materials and methods: Investigations were conducted on 40 male rats with the body mass of 200-220 g ...
M. V. Milenina, M. B. Musaev, E. E. Belova, T. S. Novik, V. E. Abramov   +4 more
doaj  

Human Fascioliasis: Current Epidemiological Status and Strategies for Diagnosis, Treatment, and Control

Research and Reports in Tropical Medicine, 2020
Maria Alejandra Caravedo,1 Miguel Mauricio Cabada1,2 1Division of Infectious Diseases Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA; 2Cusco Branch – Tropical Medicine Institute, Universidad Peruana Cayetano
Caravedo MA, Cabada MM
doaj  

STUDIES ON IMMUNOTROPIC ACTIVITY OF THE SUPRAMOLECULAR COMPLEX OF TRICLABENDAZOLE

Российский паразитологический журнал, 2019
The supramolecular complex of triclabendazole is a complex preparation based on triclabendazole with the water-soluble polysaccharide - arabinogalactan produced in impact grinders with the use of mechanochemical nanotechnology.
M. V. Milenina, K. G. Kurochkina, M. B. Musaev   +2 more
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