Results 61 to 70 of about 1,374 (169)

Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats

Российский паразитологический журнал, 2019
The purpose of the research is to assess the acute oral toxicity of the drug Altrik-Extra in mice and rats, to determine its hazard class depending on the degree of exposure to animals.Materials and methods.
E. V. Lagereva, V. E. Abramov
doaj   +1 more source

First Report of Fascioliasis of Ruminants in the Kharaa River Basin and Identification of Snail Hosts in Mongolia

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Fascioliasis is a parasitic liver disease of mammals induced by liver flukes, Fasciola hepatica and Fasciola gigantica. Fasciola spp. rely on their definitive hosts, ruminants, and intermediate hosts, snails, to survive and can incidentally infect humans as definitive hosts. Ruminant (goat, sheep, and cattle) liver and fecal samples were collected from
Lkhagvatseren Sukhbaatar, Nora G. Cleary, Davaajargal Tserennyam, Enkhjargal Enkherdene, Chinchuluun Boldbaatar, Gantuya Sambuu, Munkhjargal Tserendorj, Otgonpurev Sukhbaatar, Batsukh Zayat, Michael E. von Fricken, Lipi Buch   +10 more
wiley   +1 more source

The Role of DNA Methyltransferases in Urinary System Diseases

Cancer Innovation, Volume 4, Issue 6, December 2025.
Multiple signaling pathways mediated by DNMTs in the formation of renal fibrosis: (a) DNMTs suppress the expression of transcription factor KLF4 by mediating promoter hypermethylation, thereby promoting epithelial–mesenchymal transition and contributing to the development of renal fibrosis; (b) oxidative stress can upregulate the levels of DNMTs, which
Wei Dong, Shengbin Pei, Dacheng Zhu, Cheng Zeng, Yue Qiu, Yuxin Wu, Xinlu Jia, Siqi Zhang, Chao Li, Wenjuan Zhang, Wenbing Zhang, Zhihua Chen   +11 more
wiley   +1 more source

Anthelmintic control failure and associated risk factors reported by farmers in communal sheep farming, Oliver Tambo District, Eastern Cape, South Africa

Veterinary Record Open, Volume 12, Issue 2, December 2025.
Abstract Background Helminth control on communal farms of South Africa, primarily relies on anthelmintic drugs, administered by farmers without veterinary supervision. This study investigated risk factors associated with farmer‐reported anthelmintic control failure on communal sheep farms in Oliver Tambo District of the Eastern Cape of South Africa ...
Songezo Mavundela, William Diymba Dzemo, Oriel Thekisoe   +2 more
wiley   +1 more source

FASCIOLA HEPATICA: MORPHOMETRIC ANALYSIS OF EGGS AFTER TRICLABENDAZOLE TREATMENT

Фундаментальная и клиническая медицина, 2018
Aim. To evaluate effects of triclabendazole on the egg production by Fasciola hepatica. Materials and Methods. Fasciola hepatica were isolated from the liver of spontaneously invaded sheep after the administration of triclabendazole (10 mg/kg).
OKSANA I. Bibik, TATIANA A. Shternis, LYUBOV V. Nacheva   +2 more
doaj  

Potentiation of triclabendazole sulphoxide-induced tegumental disruption by methimazole in a triclabendazole-resistant isolate of Fasciola hepatica

Parasitology Research, 2010
A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism. The flavin monooxygenase system (FMO) was inhibited using methimazole (MTZ) to see whether a TCBZ-resistant isolate could be made more sensitive to TCBZ action.
Devine, Catherine G., Brennan, Gerard, Lanusse, C.E., Alvarez, L.I., Trudgett, Alan, Hoey, Elizabeth, Fairweather, Ian   +6 more
openaire   +4 more sources

Erratum to: Inhibition of triclabendazole metabolism in vitro by ketoconazole increases disruption to the tegument of a triclabendazole-resistant isolate of Fasciola hepatica [PDF]

Parasitology Research, 2011
A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of drug metabolism. The cytochrome P450 (CYP 450) enzyme pathway was inhibited using ketoconazole (KTZ) to see whether a TCBZ-resistant isolate could be made more sensitive to TCBZ action. The Oberon TCBZ-resistant
Devine, C., Brennan, Gerard, Lanusse, C.E., Alvarez, L.I., Trudgett, A., Hoey, E., Fairweather, Ian   +6 more
openaire   +2 more sources

Mechanochemische Methoden mit Anwendung in der Late‐Stage Modifizierung Pharmazeutisch Wirksamer Verbindungen

Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Equine fasciolosis due to Fasciola hepatica in the Community of Madrid (Spain): First report of a rare parasitic infection in horses

Veterinary Record Case Reports, Volume 13, Issue 3, September 2025.
Abstract We reported for the first time a confirmed case of equine fasciolosis in the Community of Madrid (Spain). Here, we described the clinical presentation, diagnostic approach and treatment of the affected horse, as well as the seroprevalence of Fasciola hepatica in the equestrian centre where it was detected.
Carolina R. Sanz, Juan David Carbonell, Guadalupe Miró, Arancha Meana   +3 more
wiley   +1 more source