Results 121 to 130 of about 85,814 (252)

Selective serotonin reuptake inhibitors versus tricyclic and heterocyclic antidepressants: comparison of drug adherence.

, 2000
BACKGROUND: Selective serotonin reuptake inhibitors are thought to have better discontinuation rates (i.e. less people dropping out) than tricyclic and heterocyclic antidepressant drugs.
Churchill, R, Hardy, R, C Barbui, Freemantle, N, Hardy, Rowan, R Churchill, N Freemantle, Lewis, G, Boynton, J, JR Geddes, Barbui, C, Mason, J M, Eccles, MP, G Lewis, Eccles, M P, JM Mason, Freemantle, Nick, MP Eccles, Geddes, JR, J Boynton, Hotopf, M, M Hotopf, Geddes, J R, R Hardy   +23 more
core   +1 more source

Exploring the Neuropharmacological Potential of Ligustrum sinense Relevant to Parkinson's Disease: In Vivo and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Ligustrum sinense (L. sinense) leaf extract exhibited moderate antioxidant activity (DPPH IC50 = 73.56 ± 2.18 µg/mL) and was evaluated for neuropharmacological effects at 200 and 400 mg/kg using elevated plus maze, open‐field, hole‐cross, and hole‐board tests.
Sowmitro Das, S. M. Istiaque Hamim, Md Nazmul Hasan Zilani, Kazi Sneha Chhando, Puza Das, Md Ridoy Hossain, Md. Imtiaz, Jebin Tasmin, Roney Miah, Md. Nazmul Hasan   +9 more
wiley   +1 more source

How i treat... A poisoning with tricyclic antidepressants: Potential role of a treatment with lipid emulsion

, 2017
Poisoning with tricyclic antidepressants is common and can be life-threatening. The classic management is well known (chelating gastrointestinal, sodium bicarbonate, benzodiazepine, norepinephrine).
Degesves, S., TONGLET, Martin, Berthe, G., Bertrand, X.   +3 more
core  

Reversed-phase liquid chromatography without organic solvent for determination of tricyclic antidepressants

The chromatographic behaviour of seven tricyclic antidepressants (amitryptiline, clomipramine, doxepin, imipramine, maprotiline, nortryptiline, and trimipramine) was studied using micellar mobile phases with the non-ionic surfactant Brij-35, compared to ...
García Álvarez-Coque, María Celia, Ruiz Ángel, María José, Fernández Navarro, Juan José   +2 more
core   +1 more source

Antidepressants and sexual dysfunction

, 2006
Objectives: Many patients with depression suffer from sexual dysfunction and sexual dysfunction is a recognized side-effect of antidepressants.
Northey, S, Bhugra, D, Werneke, U
core   +1 more source

Case Report: Aquaporin‐4–Positive Neuromyelitis Optica Spectrum Disorder: Diagnostic Challenges and Transition From B‐Cell Depletion Therapy to Ravulizumab

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT This case report illustrates the real‐world efficacy of complement component 5 inhibitors in a patient with neuromyelitis optica spectrum disorder who switched from rituximab because of B‐cell repopulation occurring early in the course of treatment.
Aram Zabeti
wiley   +1 more source

The Impact of Antidepressants on Gut Microbiome and Depression Management

Progress in Microbes and Molecular Biology
Depression is a widespread psychiatric disorder that significantly impacts an individual’s quality of life. It affects mental and emotional well-being and has far-reaching consequences on their physical health, relationships, and overall ability to ...
Ee-Kit Tang, Ke-Yan Loo, Angel Yun-Kuan Thye, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Malarvili Selvaraja, Sivakumar Thurairajasingam, Learn-Han Lee, Vengadesh Letchumanan   +8 more
doaj   +1 more source

Prescription Sequence Symmetry Analysis of Glucagon‐Like Peptide‐1 Receptor Agonists and Neuropsychiatric Conditions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1092-1100, October 2026.
Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are increasingly prescribed for type 2 diabetes and weight management. However, conflicting evidence from preclinical, clinical, and pharmacovigilance studies suggests potential neuropsychiatric effects.
Maria J. Alfonso Arvez, Sam Wade, Darshna Goordeen, Jenni Ilomäki, Amanda J. Cross, Monica Langiu, George S. Q. Tan   +6 more
wiley   +1 more source

Effect of intravenous midazolam on cardiac parameters in acute tricyclic antidepressants poisoning

ARYA Atherosclerosis, 2016
BACKGROUND: Midazolam is commonly and safely used in poisoning management and intensive care for the control of the agitated poisoned patients. Despite the introduction of newer and safer antidepressants, tricyclic antidepressants (TCA) are still ...
Nastaran Eizadi-Mood, Elham Aboufazeli, Valiollah Hajhashemi, Farzad Gheshlaghi, Shirinsadat Badri, Ali Mohammad Sabzghabaee   +5 more
doaj  

The α2‐Subunit Preferring GABA Positive Allosteric Modulator, N‐Desmethyl‐Clobazam in Peripheral Neuropathic Pain Patients: Results of a Phase IIa Randomised Placebo‐Controlled Ascending Dose Study

European Journal of Pain, Volume 30, Issue 9, October 2026.
ABSTRACTBackgroundN‐desmethyl clobazam (NDMC), an α2‐preferring‐α1‐sparing‐GABAA modulator, was promising in preclinical models and Phase I studies, demonstrating antihyperalgesic properties without associated sedation. This Phase IIa trial aimed at exploring the effect of NDMC in peripheral neuropathic pain (NP) patients.MethodRandomised, ascending ...
M. Besson, A. Matthey, Y. Daali, A. Ramsahye, C. Samer, J. Desmeules, F. Curtin   +6 more
wiley   +1 more source