Results 121 to 130 of about 34,503 (265)
Bipolar Disorders, Volume 28, Issue 5, August 2026.ABSTRACT Objective Bipolar disorder (BD) often emerges during mid‐adolescence and young adulthood, and leads to functional and social impairment, with a prevalence of 0.87% among Dutch youth. Lithium, the first‐line BD maintenance treatment, stabilizes mood, prevents suicide, and is well tolerated, yet its use has declined as long‐term second ...
Ravish N. Gangapersad +8 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira +3 more
wiley +1 more source
The Impact of Antidepressants on Gut Microbiome and Depression Management
Progress in Microbes and Molecular BiologyDepression is a widespread psychiatric disorder that significantly impacts an individual’s quality of life. It affects mental and emotional well-being and has far-reaching consequences on their physical health, relationships, and overall ability to ...
Ee-Kit Tang +8 more
doaj +1 more source
Clinical and Translational Science, Volume 19, Issue 8, August 2026.ABSTRACT The enzymatic activity of cytochrome P450 2D6 (CYP2D6) exhibits substantial interindividual variation, which influences drug efficacy and the risk of adverse drug reactions to various therapeutics. While current protocols for CYP2D6 genotyping or CYP2D6 phenotyping provide useful information, less invasive and simpler tools are desirable for ...
Masaki Kumondai +11 more
wiley +1 more source
Effect of intravenous midazolam on cardiac parameters in acute tricyclic antidepressants poisoning
ARYA Atherosclerosis, 2016 BACKGROUND: Midazolam is commonly and safely used in poisoning management and intensive care for the control of the agitated poisoned patients. Despite the introduction of newer and safer antidepressants, tricyclic antidepressants (TCA) are still ...
Nastaran Eizadi-Mood +5 more
doaj
Journal of Oral Rehabilitation, Volume 53, Issue 8, Page 1550-1561, August 2026.A compounded amitriptyline 10% plus lidocaine 2% mucoadhesive gel was associated with substantial pain improvement and favourable tolerability in adults with post‐traumatic trigeminal neuropathic pain (PTNP). These findings support targeted mucosal delivery as a promising practical local option and a potential medication‐sparing strategy, particularly ...
Ashley Lebel +2 more
wiley +1 more source
Arthritis Care &Research, Volume 78, Issue 7, Page 860-874, July 2026.Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo +88 more
wiley +1 more source
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII. [PDF]
J Enzyme Inhib Med Chem, 2023 Fiorentino F +4 more
europepmc +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2230-2238, July 2026.Abstract Aim Individual second‐generation antihistamines may possess differential sedative potential due to the variability in central histamine receptor H1 occupancy. This study aimed to evaluate whether the sedative potential of second‐generation antihistamines is associated with the risk of injury during Japan's pollen season. Methods We conducted a
Jumpei Taniguchi +3 more
wiley +1 more source
Potential simple and multifactorial drug-gene interactions of tricyclic antidepressants in older Australians [PDF]
Although tricyclic antidepressants are often used to treat depression in elderly people worldwide, the safety and efficacy of these drugs may be affected by both simple and multifactorial drug-gene interactions.
Thilani H. Dias (21326816) +9 more
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